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Literature summary for 6.3.1.4 extracted from

  • Su, N.; Kilberg, M.S.
    C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene (2008), J. Biol. Chem., 283, 35106-35117.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information ASNS is induced by ATF4, amino acid deprivation, or ER stress, siRNA-mediated knockdown of CHOP further enhances the induction of ASNS by either amino acid deprivation or ER stress, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis in HEK-293 cells in response to ATF4 or CHOP Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information CHOP suppresses the induction of the endogenous ASNS gene and inhibits transcription from a reporter gene driven by the ASNS promoter following activation by ATF4 or amino acid deprivation. The inhibitory effect of CHOP on the ASNS gene is not observed when truncated proteins, encoding either the N- or C-terminal portion of the protein, are expressed, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
Asparagine synthetase
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Homo sapiens
ASNS
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Homo sapiens