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4.6.1.24: ribonuclease T1

This is an abbreviated version!
For detailed information about ribonuclease T1, go to the full flat file.

Word Map on EC 4.6.1.24

Reaction

[RNA fragment]-3'-guanosine-2',3'-cyclophosphate
+
H2O
=
[RNA fragment]-3'-guanosine-3'-phosphate

Synonyms

Aspergillus oryzae ribonuclease, barnase, Binase, EC 2.7.7.26, EC 3.1.27.3, EC 3.1.4.8, Gln25-RNase T1, guanyl-preferring RNase, Guanyl-specific RNase, guanylate endoribonuclease, Guanyloribonuclease, More, MycRne, Nuclease, guanyloribo-, Nuclease, ribo-, Aspergillus oryzae, ribonuclease, ribonuclease A, Ribonuclease C2, Ribonuclease Ch, ribonuclease E/G, Ribonuclease F1, ribonuclease G, Ribonuclease guaninenucleotido-2'-transferase (cyclizing), Ribonuclease N1, Ribonuclease N3, ribonuclease NT, ribonuclease Pb2, Ribonuclease PP1, Ribonuclease SA, ribonuclease Sa2, ribonuclease T1, Ribonuclease U1, RNase A, RNase E/G, RNase F1, RNase Fl1, RNase Fl2, RNase G, RNase He1, RNase Ms, RNase N1, RNase N2, RNase NT, RNase Pb1, RNase Pb2, RNase Pc, RNase Po1, RNase Pol, RNase Sa, RNase Sa2, RNase Sa3, RNase St, RNase T1, RNase T1 RV, RNase T1-R2, RNase Th1, RNase U1, Slr1129

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.24 ribonuclease T1

Inhibitors

Inhibitors on EC 4.6.1.24 - ribonuclease T1

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-guanylic acid
-
substrate analogue
3'-guanylic acid
-
substrate analogue
3'-N-hydroxyurea-3'-deoxythymidine-5'-phosphate
competitive, inhibition is enhanced by nearly 10fold in presence of Zn2 in wild-type enzyme, no enhancement in mutant enzyme E54Q
Acetic anhydride
-
-
barstar
-
Bromoacetic acid
-
-
Ca2+
-
Neurospora crassa RNase N4
chitosan
Fe3+
-
Aspergillus niger RNase II
Guanylyl-2',5'-guanosine
-
-
histidine
-
-
iodoacetamide
-
iodoacetamide, but not iodoacetate, reacts with these His residues at pH 8.0, but not at pH 5.5
iodoacetate
Mononucleotides
-
e.g. 2'-GMP, 3'-GMP, 5'-GMP, 3'-CMP, 2'(3')-UMP
Ozone
-
loss of activity at pH 7.5, at pH 4.75 the enzyme retains a decreased but distinct enzyme activity towards RNA without alteration of substrate specificity
Phenylglyoxal
phosphate
-
-
substrate analogs
-
-
-
Tosylglycolate
-
protection by substrate analogs
additional information
-