Literature summary for 4.6.1.24 extracted from

Yakovlev, G.I.; Mitkevich, V.A.; Struminskaya, N.K.; Varlamov, V.P.; Makarov, A.A.
Low molecular weight chitosan is an efficient inhibitor of ribonucleases (2007), Biochem. Biophys. Res. Commun., 357, 584-588.

Search for more literature for 4.6.1.24

Application

Application	Comment	Organism
medicine	RNase inhibitors appear to be promising for therapy of cancer	Bos taurus
medicine	RNase inhibitors appear to be promising for therapy of cancer	Bacillus amyloliquefaciens
medicine	RNase inhibitors appear to be promising for therapy of cancer	Kitasatospora aureofaciens
medicine	RNase inhibitors appear to be promising for therapy of cancer	Aspergillus oryzae
medicine	RNase inhibitors appear to be promising for therapy of cancer	Bacillus intermedius
medicine	RNase inhibitors appear to be promising for therapy of cancer	Penicillium brevicompactum

Inhibitors

Inhibitors	Comment	Organism	Structure
chitosan	-	Aspergillus oryzae
chitosan	-	Bacillus amyloliquefaciens
chitosan	-	Bacillus intermedius
chitosan	-	Bos taurus
chitosan	-	Kitasatospora aureofaciens
chitosan	-	Penicillium brevicompactum

Organism

Organism	UniProt	Comment	Textmining
Aspergillus oryzae	-	-	-
Bacillus amyloliquefaciens	-	-	-
Bacillus intermedius	-	-	-
Bos taurus	-	-	-
Kitasatospora aureofaciens	-	-	-
Penicillium brevicompactum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bacillus amyloliquefaciens
-	Kitasatospora aureofaciens
-	Bacillus intermedius
-	Penicillium brevicompactum

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
barnase	-	Bacillus amyloliquefaciens
Binase	-	Bacillus intermedius
ribonuclease	-	Bacillus amyloliquefaciens
ribonuclease	-	Bacillus intermedius
ribonuclease A	-	Bos taurus
ribonuclease Pb2	-	Penicillium brevicompactum
Ribonuclease SA	-	Kitasatospora aureofaciens
ribonuclease T1	-	Aspergillus oryzae
RNase A	-	Bos taurus
RNase Pb2	-	Penicillium brevicompactum
RNase Sa	-	Kitasatospora aureofaciens
RNase T1	-	Aspergillus oryzae

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000033	-	chitosan	poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Kitasatospora aureofaciens
0.00008	-	chitosan	poly(A) * poly(U) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Penicillium brevicompactum
0.00009	-	chitosan	poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Penicillium brevicompactum
0.0001	-	chitosan	poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Bacillus intermedius
0.00012	-	chitosan	poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Bacillus amyloliquefaciens
0.00012	-	chitosan	poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Aspergillus oryzae
0.00021	-	chitosan	poly(I) * poly(C) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Bos taurus
0.00022	-	chitosan	poly(I) substrate, measurement is performed in 10 mM Tris, pH 7.0, containing 0.14 M NaCl and 0.1 mM EDTA	Bos taurus

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Release 2023.1 (January 2023)