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4.1.1.50: adenosylmethionine decarboxylase

This is an abbreviated version!
For detailed information about adenosylmethionine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.50

Reaction

S-adenosyl-L-methionine
=
S-adenosyl 3-(methylsulfanyl)propylamine
 +
CO2

Synonyms

Ado-MetDC, AdoMet decarboxylase, AdoMetDC, AdoMetDC/ODC, AMDC, BjSAMDC1, BjSAMDC2, BjSAMDC3, BjSAMDC4, BlsE, Bud2, MdSAMDC1, MdSAMDC2, OsSAMDC, PfAdoMetDC, protein SSO0585, S-adenosyl methionine decarboxylase, S-Adenosyl-L-methionine decarboxylase, S-adenosyl-methionine-decarboxylase, S-adenosylmethionine decarboxy-lase/ornithine decarboxylase, S-Adenosylmethionine decarboxylase, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 2, S-adenosylmethionine decarboxylase 3, S-adenosylmethionine decarboxylase 4, SAM decarboxylase, SAM-DC, SAMDC, SvPEPC, Tb927.6.4410

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.50 adenosylmethionine decarboxylase

Cloned

Cloned on EC 4.1.1.50 - adenosylmethionine decarboxylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA of Datura stramonium is introduced in Nicotiana tabacum L. cv. Xanthi in antisense orientation under the CaMV 35S promoter, by means of Agrobacterium tumefaciens and leaf disc transformation. Primary transformants efficiently transcribe the antisense SAMDC gene, but SAMDC activity and PA titers do not change. By contrast, in most transgenic shoots of the second generation, SAMDC activity is remarkably lower than in controls, and the putrescine-to-spermidine ratio is altered, mainly due to increased putrescine, even though putrescine oxidising activity (diamine oxidase, EC 1.4.3.6) does not change relative to controls. Despite the reduction in SAMDC activity, the production of ethylene, which shares with PAs the common precursor SAM, is not influenced by the foreign gene. Some plants are transferred to pots and acclimatised in a growth chamber. In these in vivo-grown second generation transgenic plants, at the vegetative stage, SAMDC activity is scarcely reduced, and PA titres do not change. Finally, the rhizogenic potential of in vitro-cultured leaf explants excised from antisense plants is significantly diminished as compared with WTones, and the response to methyl jasmonate, a stress-mimicking compound, in terms of PA conjugation, is higher and differentially affected in transgenic leaf discs relative to WT ones
enzyme alpha subunit, expression in Escherichia coli
-
expressed in Amdc-s cells (NIH3T3 cells transfected with human AdoMetDC cDNA)
-
expressed in Escherichia coli
expressed in Escherichia coli B834(DE3) cells
expressed in Escherichia coli BL21 cells
expressed in Escherichia coli BL21 Star cells
-
expressed in Escherichia coli BL21(DE3) cells
-
expressed in Escherichia coli BL21(DE3) JM109 cells
expressed in Escherichia coli JM109 cells
expressed in Escherichia coli TG1 cells
expressed in Escherichia coli Top10 cells
-
expressed in Oryza sativa
-
expressed in Oryza sativa subspecies Japonica cultivar EYI105
expressed in Saccharomyces cerevisiae strain INVSc2 using the expression vector pYES-DEST52
-
expressed in Solanum lycopersicum cultivar Ohio 8245 fruit
-
expressed in Solanum lycopersicum plants
-
expression in Arabidopsis thaliana Heynh. under the control of the cauliflower mosaic virus 35S promoter. The overexpression causes unusual visible phenotypes to various extents in transformants grown on agar plates containing sucrose. In transformants the contents of certain amino acids of the aspartic and glutamic families are markedly increased, while those of aromatic amino acids are significantly decreased
Thermostichus vulcanus
-
expression in Escherichia coli
expression in Nicotiana tabacum
-
expression in sense and antisense orientations in mouse NIH3T3 cells
-
microinjection of 1 ng of SAMDC mRNA per egg results in more than 200fold overexpression of the mRNA
-