4.1.1.50: adenosylmethionine decarboxylase

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For detailed information about adenosylmethionine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.50

4.1.1.50

polyamine

spermidine

putrescine

methylglyoxal

bisguanylhydrazone

diamine

alpha-difluoromethylornithine

brucei

prostate

decarboxylases

l-ornithine

trypanosoma

n1-acetyltransferase

antiproliferative

proenzyme

pyruvoyl

aminopropyltransferases

agmatine

agriculture

1,3-diaminopropane

synthesis

pentamidine

trypanosomatids

n1-acetylspermidine

medicine

pao

pharmacology

adenosyltransferase

antizyme

dl-alpha-difluoromethylornithine

glyoxal

drought

rhodesiense

trypanosomiasis

analysis

trypanothione

guanylhydrazone

difluoromethylornithine

uorfs

normfinder

methylthioadenosine

biotechnology

arginase

polyamine-depleted

cadaverine

genorm

berenil

enzyme-activated

Reaction

S-adenosyl 3-(methylsulfanyl)propylamine

Synonyms

Ado-MetDC, AdoMet decarboxylase, AdoMetDC, AdoMetDC/ODC, AMDC, BjSAMDC1, BjSAMDC2, BjSAMDC3, BjSAMDC4, BlsE, Bud2, MdSAMDC1, MdSAMDC2, OsSAMDC, PfAdoMetDC, protein SSO0585, S-adenosyl methionine decarboxylase, S-Adenosyl-L-methionine decarboxylase, S-adenosyl-methionine-decarboxylase, S-adenosylmethionine decarboxy-lase/ornithine decarboxylase, S-Adenosylmethionine decarboxylase, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 2, S-adenosylmethionine decarboxylase 3, S-adenosylmethionine decarboxylase 4, SAM decarboxylase, SAM-DC, SAMDC, SvPEPC, Tb927.6.4410

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.50 adenosylmethionine decarboxylase

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Results	in table
89	Activating Compound
15978	AA Sequence
12	Application
1	CAS Registry Number
37	Cloned(Commentary)
42	Cofactor
13	Crystallization (Commentary)
588	Disease/ Diagnostics
22	Expression
12	General Information
2	General Stability
35	IC50 Value
396	Inhibitors
9	kcat/KM [mM/s]
8	Ki Value [mM]
46	KM Value [mM]
3	Localization
43	Metals/Ions
74	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
170	Organism
8	Pathway
93	PDB ID
15	pH Optimum
3	pH Range
3	pH Stability
16	Posttranslational Modification
50	Protein Variants
41	Purification (Commentary)
5	Reaction
2	Reaction Type
167	Reference
1	Renatured (Commentary)
104	Source Tissue
35	Specific Activity [micromol/min/mg]
11	Storage Stability
148	Substrates and Products (Substrate)
58	Subunits
157	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
15	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.1.1.50 - adenosylmethionine decarboxylase

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(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide

Trypanosoma cruzi

stimulation in the range of 0.1-10 microM, inhibition at higher comcentration

678201

1,15-diamino-4,12-diazapentadecane

1,3-diaminopropane

1,5-Diaminopentane

1,6-diaminohexane

58% of activation by putrescine

650473

1,7-Diaminoheptane

Onchocerca volvulus

45% of activation by putrescine

33-003

cadaverine

difluoromethylornithine

Homo sapiens

5 mM causes an induction of the enzyme activity

702137

N1-acetylspermidine

Onchocerca volvulus

60% of activation by putrescine

650473

phenanthrene

Riccia fluitans

concentrations of phenanthrene up to 0.5 microM cause significant increases in the activity of SAMDC, with a resultant increase in tissue polyamine levels

pi' subunit

PMW-2000-11-13-5

putrescine

pyruvate

spermidine

spermine

YZ-33-046

YZ-33-050C

additional information

5 entries