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Literature summary for 4.1.1.50 extracted from

  • Bale, S.; Brooks, W.; Hanes, J.W.; Mahesan, A.M.; Guida, W.C.; Ealick, S.E.
    Role of the sulfonium center in determining the ligand specificity of human S-adenosylmethionine decarboxylase (2009), Biochemistry, 48, 6423-6430.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.50

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine, hanging drop vapor diffusion method, at 22°C in 13-16% (w/v) polyethylene glycol 8000, 100 mM tris(hydroxymethyl)aminomethane (pH 8.0-9.0), and 10 mM dithiothreitol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine
-
 Homo sapiens
5'-deoxy-5'-dimethylthioadenosine
-
 Homo sapiens
5'-deoxy-5'-[N-methyl-N-(3-hydrazinopropyl)amino]adenosine
-
 Homo sapiens
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)ethyl]amino]adenosine
-
 Homo sapiens
CGP48664A i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Homo sapiens
methylglyoxal bis(guanylhydrazone)
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17707
-
-

Purification (Commentary)

Purification (Comment) Organism
TALON metal affinity resin column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AdoMetDC
-
 Homo sapiens
S-Adenosylmethionine decarboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens