4.1.1.50: adenosylmethionine decarboxylase

This is an abbreviated version!
For detailed information about adenosylmethionine decarboxylase, go to the full flat file.

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Synonyms

Ado-MetDC, AdoMet decarboxylase, AdoMetDC, AdoMetDC/ODC, AMDC, BjSAMDC1, BjSAMDC2, BjSAMDC3, BjSAMDC4, BlsE, Bud2, MdSAMDC1, MdSAMDC2, OsSAMDC, PfAdoMetDC, protein SSO0585, S-adenosyl methionine decarboxylase, S-Adenosyl-L-methionine decarboxylase, S-adenosyl-methionine-decarboxylase, S-adenosylmethionine decarboxy-lase/ornithine decarboxylase, S-Adenosylmethionine decarboxylase, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 2, S-adenosylmethionine decarboxylase 3, S-adenosylmethionine decarboxylase 4, SAM decarboxylase, SAM-DC, SAMDC, SvPEPC, Tb927.6.4410

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.50 adenosylmethionine decarboxylase

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Results	in table
89	Activating Compound
15978	AA Sequence
12	Application
1	CAS Registry Number
37	Cloned(Commentary)
42	Cofactor
13	Crystallization (Commentary)
588	Disease/ Diagnostics
22	Expression
12	General Information
2	General Stability
35	IC50 Value
396	Inhibitors
9	kcat/KM [mM/s]
8	Ki Value [mM]
46	KM Value [mM]
3	Localization
43	Metals/Ions
74	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
170	Organism
8	Pathway
93	PDB ID
15	pH Optimum
3	pH Range
3	pH Stability
16	Posttranslational Modification
50	Protein Variants
41	Purification (Commentary)
5	Reaction
2	Reaction Type
167	Reference
1	Renatured (Commentary)
104	Source Tissue
35	Specific Activity [micromol/min/mg]
11	Storage Stability
148	Substrates and Products (Substrate)
58	Subunits
157	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
15	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.1.50 - adenosylmethionine decarboxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium + CO2

S-adenosyl-L-methionine + H+

Solanum tuberosum

-

-

700713

-

-

?

Adenosylethionine

?

Escherichia coli

-

poor substrate

4668

-

-

?

L-lysine

?

Arabidopsis thaliana

Q96286

-

651763

-

651763

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2

2 entries

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

93 entries

S-adenosyl-L-methionine

?

18 entries

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

6 entries

additional information

?

-

15 entries

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2

Plasmodium falciparum

-

-

716159

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2

Rattus norvegicus

-

-

714392

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Acanthamoeba castellanii

-

-

4694

-

4694

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Acanthamoeba castellanii NEFF

-

-

4694

-

4694

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Actinidia deliciosa

-

-

706283

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Aquifex aeolicus

O66615

-

701648

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Arabidopsis thaliana

Q96286

-

651763

-

651763

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Bacillus subtilis

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Bos taurus

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Brassica rapa subsp. pekinensis

-

-

4666

-

4666

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Caenorhabditis elegans

-

-

650480

-

650480

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Caenorhabditis elegans

O02655

-

4685

-

4685

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Catharanthus roseus

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Clostridium acetobutylicum

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Crithidia fasciculata

-

-

651333

-

651333

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Datura stramonium

-

-

706281

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Datura stramonium

Q96555

-

706253

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4660

-

4660

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4662

-

4662

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4663

-

4663

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4672

-

4672

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4680

-

4680

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

4681

-

4681

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Escherichia coli HT527

-

-

4662

-

4662

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Glycine max

-

-

4691

-

4691

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

4686

-

4686

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

4688

-

4688

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

4689

-

4689

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

4690

-

4690

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

4693

-

4693

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

701731, 702137, 703505, 705663

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

P17707

-

701648, 702325

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

-

-

702325

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Homo sapiens

P17707

-

705022

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Lytechinus pictus

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Lytechinus pictus

-

-

4678

-

4678

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Methanocaldococcus jannaschii

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Methanocaldococcus jannaschii

-

high specificity

652545

-

652545

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4665

-

4665

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4667

-

4667

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4675

-

4675

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4689

-

4689

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4690

-

4690

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4696

-

4696

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

4699

-

4699

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

-

-

704069

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mus musculus

P0DMN7

-

4683

-

4683

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Mycobacterium tuberculosis variant bovis

-

-

4661

-

4661

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Onchocerca volvulus

-

-

4687

-

4687

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Oryza sativa Japonica Group

Q0JC10

-

706253

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Plasmodium falciparum

-

-

698970, 701649

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Plasmodium falciparum NF54

-

-

701649

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4667

-

4667

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4669

-

4669

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4670

-

4670

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4673

-

4673

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4677

-

4677

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4678

-

4678

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4679

-

4679

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4682

-

4682

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4692

-

4692

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4697

-

4697

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Rattus norvegicus

-

-

4698

-

4698

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Riccia fluitans

-

-

694642

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharolobus solfataricus

-

-

4695

-

4695

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharolobus solfataricus

Q9UWY8

-

719848

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharolobus solfataricus

Q9UWY8

the crenarchaeal S-adenosylmethionine decarboxylase has no arginine decarboxylase activity

719848

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharolobus solfataricus P2

Q9UWY8

-

719848

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharolobus solfataricus P2

Q9UWY8

the crenarchaeal S-adenosylmethionine decarboxylase has no arginine decarboxylase activity

719848

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharomyces cerevisiae

-

-

4668

-

4668

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharomyces cerevisiae

-

-

4671

-

4671

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharomyces cerevisiae

-

-

4676

-

4676

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Saccharomyces cerevisiae

-

-

703505, 704987

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Solanum tuberosum

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Solanum tuberosum

Q04694

-

701648

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Thermotoga maritima

-

-

703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Thermotoga maritima

Q9WZC3

-

701478, 701648

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Thermotoga maritima

-

-

701648

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma brucei

-

-

4664

-

4664

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma brucei

-

-

701648, 701731, 702570, 703505, 703514

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma brucei

A5HNV7

-

682576

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma brucei brucei

-

-

701736

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma brucei brucei Lab 110 EATRO

-

-

701736

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma brucei rhodesiense

-

-

701736

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma cruzi

-

-

4684

-

4684

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma cruzi

-

-

649965

-

649965

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma cruzi

-

-

678201, 703505

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Trypanosoma cruzi

O76240

-

653168

-

653168

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Xenopus laevis

-

-

701647

-

-

?

S-adenosyl-L-methionine

(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

Zea mays

-

-

4674

-

4674

?

S-adenosyl-L-methionine

?

Bos taurus

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Bos taurus

-

the enzyme protein turns over very rapidly in growing or differentiating tissues

4668

-

-

?

S-adenosyl-L-methionine

?

Escherichia coli

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Homo sapiens

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Homo sapiens

-

key enzyme in polyamine biosynthesis

4689, 4693

-

-

?

S-adenosyl-L-methionine

?

Homo sapiens

-

the enzyme protein turns over very rapidly in growing or differentiating tissues

4668

-

-

?

S-adenosyl-L-methionine

?

Lytechinus pictus

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Methanocaldococcus jannaschii

-

-

651672

-

651672

?

S-adenosyl-L-methionine

?

Mus musculus

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Mus musculus

-

major regulatory enzyme in polyamine biosynthesis

4696, 4699

-

-

?

S-adenosyl-L-methionine

?

Mus musculus

-

key enzyme in polyamine biosynthesis

4675, 4689

-

-

?

S-adenosyl-L-methionine

?

Mus musculus

-

the enzyme protein turns over very rapidly in growing or differentiating tissues

4668

-

-

?

S-adenosyl-L-methionine

?

Onchocerca volvulus

-

key enzyme in polyamine biosynthesis

4687

-

-

?

S-adenosyl-L-methionine

?

Rattus norvegicus

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Rattus norvegicus

-

the enzyme protein turns over very rapidly in growing or differentiating tissues

4668

-

-

?

S-adenosyl-L-methionine

?

Saccharolobus solfataricus

-

major regulatory enzyme in polyamine biosynthesis

4695

-

-

?

S-adenosyl-L-methionine

?

Saccharomyces cerevisiae

-

key enzyme in the biosynthetic pathway for spermidine and spermine

4668

-

-

?

S-adenosyl-L-methionine

?

Zea mays

-

EC 4.1.1.50 and EC 2.5.1.16 appear to function in sequence in animals and microorganisms in the synthesis of spermidine

4674

-

-

?

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

Homo sapiens

-

-

749303

-

-

?

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

Leishmania donovani

-

-

737602

-

-

?

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

Leishmania donovani

Q25264

-

728609

-

-

?

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

Saccharomyces cerevisiae

-

-

726669

-

-

?

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

Streptomyces griseochromogenes

Q841K9

-

728618

-

-

?

S-adenosyl-L-methionine

S-adenosyl 3-(methylthio)propylamine + CO2

Trypanosoma brucei

-

-

727974, 728337

-

-

?

additional information

?

-

Arabidopsis thaliana

-

key rate-limiting enzyme located in the polyamine biosynthesis pathway. The SAMDC 5'-leader sequence participates in gene regulation at both the transcriptional and the posttranslational levels, which enables plants to sense their internal polyamine or environmental changes

666640

-

-

?

additional information

?

-

Brassica juncea

O49972

key enzyme involved in polyamine biosynthetic pathway

666555

-

-

?

additional information

?

-

Brassica juncea

Q42613

key enzyme involved in polyamine biosynthetic pathway

666555

-

-

?

additional information

?

-

Brassica juncea

Q6QJ69

key enzyme involved in polyamine biosynthetic pathway

666555

-

-

?

additional information

?

-

Brassica juncea

Q9SDM8

key enzyme involved in polyamine biosynthetic pathway

666555

-

-

?

additional information

?

-

Homo sapiens

-

adhesion-dependent expression of S-adenosylmethionine decarboxylase contributes to extracellular matrix-dependent differentiation of human salivary gland epithelial cells

665812

-

-

?

additional information

?

-

Homo sapiens

-

key enzyme of polyamine biosynthetic pathway

664878

-

-

?

additional information

?

-

Homo sapiens

-

S-adenosylmethionine decarboxylase is a key enzyme in the synthesis of polyamines essential for cell growth and proliferation. Its overexpression induces the transformation of murine fibroblasts in both sense and antisense orientations, yielding highly invasive tumors in nude mice. Thymosin B4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase–transfected fibroblasts

664510

-

-

?

additional information

?

-

Malus domestica

Q852S8

MdSAMDC2 is mainly involved in stress responses

665040

-

-

?

additional information

?

-

Malus domestica

-

MdSAMDC2 is mainly involved in stress responses

665040

-

-

?

additional information

?

-

Malus sylvestris

Q852S9

MdSAMDC1 is mainly involved in fruit development and cell growth

665040

-

-

?

additional information

?

-

Mus musculus

-

key rate-controlling enzyme in the synthesis of spermidine and spermine. Overexpression of AdoMetDC does not produce an overt cardiac phenotype, but there is an increased cardiac hypertrophy after beta-adrenergic stimulation, and crosses of alpha-myosin heavy chain/ADoMetDC mice with alpha-myosin heavy chain/ornithine decarboxylase mice are lethal at an early embryonic stage

663973

-

-

?

additional information

?

-

Oryza sativa

-

S-adenosyl-L-methionine decarboxylase gene of cold-tolerant japonica cultivar Yukihikari and cold-susceptible indica variety TKM9 is differentially expressed under low temperature stress. Upon exposure to cold stress (5°C) the level of OsSAMDC transcripts in the cold-resistant Yukihihari genotype continues to increase for up to 72 h. There is no change in OsSAMDC transcription in the cold-susceptible indica cultivar TLM9 under the same conditions

666367

-

-

?

additional information

?

-

Riccia fluitans

-

synthesis of the triamine spermidine and the tetramine spermine is achieved by the sequential addition of aminopropyl moieties from decarboxylated S-adenosylmethionine, synthesized by the enzyme S-adenosylmethionine decarboxylase

694642

-

-

?

additional information

?

-

Thermotoga maritima

-

critical regulatory enzyme of the polyamine biosynthetic pathway

665548

-

-

?