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Literature summary for 4.1.1.50 extracted from

  • Da'dara, A.A.; Mett, H.; Walter, R.D.
    MGBG analogues as potent inhibitors of S-adenosylmethionine decarboxylase of Onchocerca volvulus (1998), Mol. Biochem. Parasitol., 97, 13-19.
    View publication on PubMed
Search for more literature for 4.1.1.50

Activating Compound

Activating Compound Comment Organism Structure
putrescine stimulation Onchocerca volvulus
putrescine maximal stimulation at 1 mM Onchocerca volvulus

Application

Application Comment Organism
pharmacology potentially important target for chemotherapy of filiarial infection Onchocerca volvulus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Onchocerca volvulus

Inhibitors

Inhibitors Comment Organism Structure
4-Amidinoindan-1-(2'-amidino)hydrazone i.e. CGP 48664 Onchocerca volvulus
Berenil reversible Onchocerca volvulus
Bis[[3-(aminoiminomethyl)phenyl]methylene]carbonimidic dihydrazide trihydrochloride i.e. CGP 40215A Onchocerca volvulus
MDL 73811 irreversibel Onchocerca volvulus
methylglyoxal bis(guanylhydrazone) and analogues Onchocerca volvulus
additional information inhibited by CGP 51467A, CGP 48009A, and CGP 62577A Onchocerca volvulus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine Onchocerca volvulus key enzyme in polyamine biosynthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Onchocerca volvulus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Onchocerca volvulus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
S-adenosyl-L-methionine key enzyme in polyamine biosynthesis Onchocerca volvulus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Onchocerca volvulus