3.4.21.38: coagulation factor XIIa
This is an abbreviated version!
For detailed information about coagulation factor XIIa, go to the full flat file.
Word Map on EC 3.4.21.38
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3.4.21.38
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kininogen
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clot
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platelet
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thrombin
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thrombosis
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plasminogen
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bradykinin
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anticoagulant
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bleeding
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thromboplastin
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fibrinolysis
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fibrinogen
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prothrombin
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hereditary
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heparin
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fibrin
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antithrombin
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plasmin
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kinin
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procoagulant
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angioedema
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hemostasis
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viii
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kallikrein-kinin
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amidolytic
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autoactivation
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zymogen
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willebrand
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kaolin
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thromboembolic
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antithrombotic
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c1-inhibitor
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fxia
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d-dimers
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c1-inh
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hypercoagulability
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antiphospholipid
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thrombin-antithrombin
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c1s
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fletcher
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2-antiplasmin
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fibrinopeptide
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euglobulins
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c1-esterase
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thrombophilia
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synthesis
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drug development
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medicine
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recalcification
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recalcified
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blood-contacting
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bradykinin-mediated
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icatibant
- 3.4.21.38
- kininogen
- clot
- platelet
- thrombin
- thrombosis
- plasminogen
- bradykinin
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anticoagulant
-
bleeding
- thromboplastin
-
fibrinolysis
- fibrinogen
- prothrombin
- hereditary
- heparin
- fibrin
- antithrombin
- plasmin
- kinin
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procoagulant
- angioedema
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hemostasis
- viii
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kallikrein-kinin
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amidolytic
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autoactivation
- zymogen
- willebrand
- kaolin
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thromboembolic
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antithrombotic
- c1-inhibitor
- fxia
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d-dimers
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c1-inh
- hypercoagulability
-
antiphospholipid
-
thrombin-antithrombin
- c1s
-
fletcher
-
2-antiplasmin
-
fibrinopeptide
-
euglobulins
- c1-esterase
- thrombophilia
- synthesis
- drug development
- medicine
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recalcification
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recalcified
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blood-contacting
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bradykinin-mediated
- icatibant
Reaction
selective cleavage of Arg-/-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa =
Synonyms
activated coagulation factor XII, activated factor XII, alpha-FXIIa, alphaFXIIa, beta-factor XIIa, beta-FXIIa, blood coagulation factor XII, blood-coagulation factor XII, activated beta, blood-coagulation factor XIIabeta, blood-coagulation factor XIIf, coagulation beta-factor XIIa, coagulation factor XII, coagulation factor XIIa, F12, factor XII, factor XII Osaka, factor XIIa, FXII, FXIIa, HAF, Hageman factor, Hageman factor beta-fragment, Hageman factor fragment HFf, Hagemann factor, kallikreinogen, activator, prealbumin activator, prekallikrein activator, single-chain FXII
ECTree
3.4.21.38 coagulation factor XIIaAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.21.38 - coagulation factor XIIa
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
factor XII + H2O
factor XIIa + ?
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the enzyme undergoes autoactivation to alpha-fXIIa in the presence of polyphosphate
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?
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg + 4-nitroaniline
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?
factor VII + H2O
factor VIIa
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bovine factor VII, a single Arg-Ile bond in factor VII is cleaved and the single chain form of factor VII is converted into a two-chain molecule
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?
factor XI + H2O
factor XIa + ?
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cleavage of an internal peptide bond in each of the two precursor chains
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?
factor XI + H2O
factor XIa + ?
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691466, 696541, 696931, 696939, 697877, 699180, 700245, 717423, 732402, 752492, 753067, 753351, 754124, 755579, 755586
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?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
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?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
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cleavage of a single peptide bond
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?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
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cleavage of a single peptide bond
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?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
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cleavage of a single peptide bond
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?
additional information
?
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surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview
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?
additional information
?
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surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview
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?
additional information
?
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surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview
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?
additional information
?
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participation of the Hageman factor-dependent system in the inflammatory response to pseudomonal infections, due to the initiation of the system by bacterial elastase
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?
additional information
?
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increased levels of activated coagulation factor XIIa are associated with coronary heart disease, sepsis, and diabetes
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?
additional information
?
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roles of enzyme as a modulator of cellular adhesion, migration and vascularization
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?
additional information
?
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changes of plasma variations of different types of XIIa measured followed by thrombolytic therapy of patients with acute ST-elevation myocardial infarction
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?
additional information
?
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changes of plasma variations of different types of XIIa measured followed by thrombolytic therapy of patients with acute ST-elevation myocardial infarction
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?
additional information
?
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FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin
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?
additional information
?
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FXII autoactivates by contact with a variety of artificial or biologic negatively charged surfaces (contact activation), resulting in blood coagulation and activation of the inflammatory kallikrein-kinin and complement systems
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?
additional information
?
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FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis
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?
additional information
?
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coagulation factor XII is a liver-derived serine protease involved in fibrinolysis, coagulation, and inflammation, regulation of FXII expression by TGF-beta-1, a multifunctional cytokine, overview
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?
additional information
?
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hemodynamic and sympathoadrenal responses to coagulation beta-FXIIa or related new pressor protein, NPP, mechanism of action of NPP/beta-FXIIa, overview. New pressor protein, NPP, is an extrarenal, approximately 30 kDa anionic enzyme that potently elevates blood pressure (BP), heart rate (HR) and sympathoadrenal catecholamines in bioassays
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?
additional information
?
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surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview
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?
additional information
?
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usage of measurement of prekallkrein hydrolysis to kallikrein by activated factor XII at test hydrophilic clean glass and hydrophobic silanized glass surfaces in the presence of bovine serum albumin, BSA. Activation after contact of the zymogen FXII with a test hydrophobic surface to activated FXII occurs only if putatively adsorbed FXIIa is competitively displaced by BSA, overview. An anionic hydrophilic surface is not a necessary cofactor for FXIIa-mediated hydrolysis of PK, and PK hydrolysis does not need to occur by an activation complex assembled directly on an anionic, activating surface. Contact activation of FXII (autoactivation) is not specific to anionic hydrophilic surfaces. Protein-adsorption competition is an essential feature that must be included in any comprehensive mechanism of surface-induced blood coagulation. Activation of zymogen FXII to FXIIa by autoactivation
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?
additional information
?
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enzyme contributes to pathologic clotting through the intrinsic pathway
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?
additional information
?
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FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis
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?
additional information
?
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blood pressure and heart rate estimated in bioassay rats after intravenous bolus of the activated beta-fragment of human coagulation factor XIIa
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?
