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3.4.21.38: coagulation factor XIIa

This is an abbreviated version!
For detailed information about coagulation factor XIIa, go to the full flat file.

Word Map on EC 3.4.21.38

Reaction

selective cleavage of Arg-/-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa =

Synonyms

activated coagulation factor XII, activated factor XII, alpha-FXIIa, alphaFXIIa, beta-factor XIIa, beta-FXIIa, blood coagulation factor XII, blood-coagulation factor XII, activated beta, blood-coagulation factor XIIabeta, blood-coagulation factor XIIf, coagulation beta-factor XIIa, coagulation factor XII, coagulation factor XIIa, F12, factor XII, factor XII Osaka, factor XIIa, FXII, FXIIa, HAF, Hageman factor, Hageman factor beta-fragment, Hageman factor fragment HFf, Hagemann factor, kallikreinogen, activator, prealbumin activator, prekallikrein activator, single-chain FXII

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.38 coagulation factor XIIa

Expression

Expression on EC 3.4.21.38 - coagulation factor XIIa

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
monocyte-derived microparticles increase FXIIa activity, but to a lesser extent than platelet- and erythrocyte-derived microparticles
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transforming growth factor-beta1, TGF-beta1, a multifunctional cytokine, induces FXII expression, which is specifically repressed by the JNK inhibitor, and by JNK and Smad3 antisense oligonucleotides, but not by MEK, p38, or phosphoinositide 3-kinase blockers, overview. Treatment of human lung fibroblasts with TGF-beta1 results in a time-dependent increase in FXII production, activation of p44/42, p38, JNK, and Akt, and phosphorylation and translocation into the nucleus of Smad3. The FXII promoter contains the -299/+1 region, that is sufficient for TGF-beta1 to induce FXII expression, but the activation of FXII expression also requires Smad binding to TGF-beta1 at the a potential Smad binding element at position -272/-269 (SBE-(-272/-269)) of the TGF-beta1 promoter. JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts
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