Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Kallikrein | mediates activation of the zymogen FXII | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | preparation of 3-aminopropyltriethoxysilane or n-octadecyltrichlorosilane particles as surfaces, i.e. procoagulants, for contact with the zymogen FXII, its kallikrein-mediated activation, and the activation of the human blood coagulation, surface cotact and assay method development and evaluation, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prekallikrein + H2O | Homo sapiens | - |
kallikrein + kallikrein prepeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | kallikrein mediates activation of the zymogen FXII. Although autohydrolysis of FXII by FXIIa may be a significant reaction in neat protein solutions, it is insignificant in plasma, autohydrolysis also is a negligible contributor to FXII activation in material-induced plasma coagulation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prekallikrein + H2O | - |
Homo sapiens | kallikrein + kallikrein prepeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
coagulation factor XII | - |
Homo sapiens |
FXII | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | kallikrein-mediated activation of the blood zymogen FXII dominates the activation of human blood plasma coagulation by contact with hydrophilic or hydrophobic surfaces, i.e. procoagulants, overview | Homo sapiens |