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Literature summary for 3.4.21.38 extracted from

  • Chatterjee, K.; Guo, Z.; Vogler, E.; Siedlecki, C.
    Contributions of contact activation pathways of coagulation factor XII in plasma (2009), J. Biomed. Mater. Res. A, 90, 27-34.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Kallikrein mediates activation of the zymogen FXII Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information preparation of 3-aminopropyltriethoxysilane or n-octadecyltrichlorosilane particles as surfaces, i.e. procoagulants, for contact with the zymogen FXII, its kallikrein-mediated activation, and the activation of the human blood coagulation, surface cotact and assay method development and evaluation, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prekallikrein + H2O Homo sapiens
-
kallikrein + kallikrein prepeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification kallikrein mediates activation of the zymogen FXII. Although autohydrolysis of FXII by FXIIa may be a significant reaction in neat protein solutions, it is insignificant in plasma, autohydrolysis also is a negligible contributor to FXII activation in material-induced plasma coagulation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prekallikrein + H2O
-
Homo sapiens kallikrein + kallikrein prepeptide
-
?

Synonyms

Synonyms Comment Organism
coagulation factor XII
-
Homo sapiens
FXII
-
Homo sapiens

General Information

General Information Comment Organism
physiological function kallikrein-mediated activation of the blood zymogen FXII dominates the activation of human blood plasma coagulation by contact with hydrophilic or hydrophobic surfaces, i.e. procoagulants, overview Homo sapiens