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Davie, E.W.; Fujikawa, K.; Kurachi, K.; Kisiel, W.
The role of serine proteases in the blood coagulation cascade
Adv. Enzymol. Relat. Areas Mol. Biol.
48
277-318
1979
Bos taurus
brenda
McMullen, B.A.; Fujikawa, K.
Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor)
J. Biol. Chem.
260
5328-5341
1985
Homo sapiens
brenda
Silverberg, M.; Kaplan, A.P.
Enzymatic activities of activated and zymogen forms of human Hageman factor (factor XII)
Blood
60
64-70
1982
Homo sapiens
brenda
Hojima, Y.; Pierce, J.V.; Pisano, J.J.
Pumpkin seed inhibitor of human factor XIIa (activated Hageman factor) and bovine trypsin
Biochemistry
21
3741-3746
1982
Homo sapiens
brenda
Semba, U.; Yamamoto, T.; Kunisada, T.; Shibuya, Y.; Tanase, S.; Kambara, T.; Okabe, H.
Primary structure of guinea-pig Hageman factor: sequence around the cleavage site differs from the human molecule
Biochim. Biophys. Acta
1159
113-121
1992
Cavia porcellus, Homo sapiens
brenda
Fujikawa, K.; Kurachi, K.; Davie, E.W.
Characterization of bovine factor XIIa (activated Hageman factor)
Biochemistry
16
4182-4188
1977
Bos taurus
brenda
Kisiel, W.; Fujikawa, K.; Davie, E.W.
Activation of bovine factor VII (proconvertin) by factor XIIa (activated Hageman factor)
Biochemistry
16
4189-4194
1977
Bos taurus
brenda
Kurachi, K.; Davie, E.W.
Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor)
Biochemistry
16
5831-5839
1977
Bos taurus
brenda
Ratnoff, O.D.; Saito, H.
Amidolytic properties of single-chain activated Hageman factor
Proc. Natl. Acad. Sci. USA
76
1461-1463
1979
Homo sapiens
brenda
Que, B.G.; Davie, E.W.
Characterization of a cDNA coding for human factor XII (Hageman Factor)
Biochemistry
25
1525-1528
1986
Homo sapiens
brenda
Cho, K.; Tanaka, T.; Cook, R.R.; Kisiel, W.; Fujikawa, K.; Kurachi, K.
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates
Biochemistry
23
644-650
1984
Homo sapiens
brenda
Loiseau, C.; Randriamahazaka, H.N.; Nigretto, J.M.
Explicit constants for the dextran-sulfate-mediated activation and autoactivation of purified human factor XII (Hageman factor)
Eur. J. Biochem.
239
692-701
1996
Homo sapiens
brenda
Gordon, E.M.; Johnson, T.R.; Ramos, L.P.; Schmeidler-Sapiro, K.T.
Enhanced expression of factor XII (Hageman factor) in isolated livers of estrogen- and prolacton-treated rats
J. Lab. Clin. Med.
117
353-358
1991
Rattus norvegicus
brenda
Nuijens, J.H.; Huijbregts, C.C.M.; Eerenberg-Belmer, A.J.M.; Meijers, J.C.M.; Bouma, B.N.; Hack, C.E.
Activation of the contact system of coagulation by a monoclonal antibody directed against a neodeterminant in the heavy chain region of human coagulation factor XII (Hageman factor)
J. Biol. Chem.
264
12941-12949
1989
Homo sapiens
brenda
Real, K.J.; Masterson, B.F.
Availability in pooled normal blood plasma of activated Hageman factor and kallikrein for contact induced coagulation
Biochem. Soc. Trans.
26
S274
1998
Homo sapiens
brenda
Samuel, M.; Samuel, E.; Villanueva, G.B.
The low pH stability of human coagulation factor XII (Hageman factor) is due to reversible conformational transitions
Thromb. Res.
75
259-268
1994
Homo sapiens
brenda
Gordon, E.M.; Gallagher, C.A.; Johnson, T.R.; Blossey, B.K.; Ilan, J.
Hepatocytes express blood coagulation factor XII (Hageman factor)
J. Lab. Clin. Med.
115
463-469
1990
Rattus norvegicus
brenda
Fujikawa, K.; Davie, E.W.
Human factor XII (Hageman factor)
Methods Enzymol.
80
198-211
1981
Homo sapiens
brenda
Fujikawa, K.
Bovine Hageman factor and its fragments
Methods Enzymol.
163
54-68
1988
Bos taurus
brenda
Silverberg, M.; Kaplan, A.P.
Human Hageman factor and its fragments
Methods Enzymol.
163
68-80
1988
Homo sapiens
brenda
Yamamoto, T.; Shibuya, Y.; Nishino, N.; Okabe, H.; Kambara, T.
Activation of human Hageman factor by Pseudomonas aeruginosa elastase in the presence or absence of negatively charged substance in vitro
Biochim. Biophys. Acta
1038
231-239
1990
Homo sapiens
brenda
Shan, J.; Baguinon, M.; Zheng, L.; Krishnamoorthi, R.
Expression, refolding, and activation of the catalytic domain of human blood coagulation factor XII
Protein Expr. Purif.
27
143-149
2003
Homo sapiens
brenda
Carmona, F.; Lazaro, I.; Reverter, J.C.; Tassies, D.; Font, J.; Cervera, R.; Balasch, J.
Impaired factor XIIa-dependent activation of fibrinolysis in treated antiphospholipid syndrome gestations developing late-pregnancy complications
Am. J. Obstet. Gynecol.
194
457-465
2006
Homo sapiens
brenda
Lowe, G.D.; Rumley, A.; McMahon, A.D.; Ford, I.; OReilly, D.S.; Packard, C.J.; Packard, C.J.
Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease
Arterioscler. Thromb. Vasc. Biol.
24
1529-1534
2004
Homo sapiens
brenda
Johne, J.; Blume, C.; Benz, P.M.; Pozgajova, M.; Ullrich, M.; Schuh, K.; Nieswandt, B.; Walter, U.; Renne, T.
Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma
Biol. Chem.
387
173-178
2006
Homo sapiens
brenda
Kleinschnitz, C.; Stoll, G.; Bendszus, M.; Schuh, K.; Pauer, H.U.; Burfeind, P.; Renne, C.; Gailani, D.; Nieswandt, B.; Renne, T.
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
J. Exp. Med.
203
513-518
2006
Mus musculus
brenda
Ebbesen, L.S.; Ingerslev, J.
Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II
J. Nutr.
135
1836-1840
2005
Rattus norvegicus
brenda
Latacha, M.P.; Schaiff, W.T.; Eisenberg, P.R.; Abendschein, D.R.
Factor XII-dependent increases in thrombin activity induce carboxypeptidase-mediated attenuation of pharmacological fibrinolysis
J. Thromb. Haemost.
2
128-134
2004
Homo sapiens
brenda
Schousboe, I.
Endothelial cells express a matrix protein which binds activated factor XII in a zinc-independent manner
Thromb. Haemost.
95
312-319
2006
Homo sapiens
brenda
Gallimore, M.J.; Harris, S.L.; Jones, D.W.; Winter, M.
Plasma levels of factor XII, prekallikrein and high molecular weight kininogen in normal blood donors and patients having suffered venous thrombosis
Thromb. Res.
114
91-96
2004
Homo sapiens
brenda
Amfilochiadis, A.A.; Backx, P.H.; Floras, J.S.
Adrenomedullary catecholamine, pressor and chronotropic responses to human coagulation beta-FXIIa mediated by endogenous kinins
J. Hypertens.
26
61-69
2008
Rattus norvegicus (D3ZTE0)
brenda
Poenitz, V.; Pritchard, D.; Grundt, H.; Nilsen, D.W.
Specific types of activated Factor XII increase following thrombolytic therapy with tenecteplase
J. Thromb. Thrombolysis
22
199-203
2006
Homo sapiens (P00748), Homo sapiens
brenda
Kravtsov, D.V.; Matafonov, A.; Tucker, E.I.; Sun, M.F.; Walsh, P.N.; Gruber, A.; Gailani, D.
Factor XI contributes to thrombin generation in the absence of factor XII
Blood
114
452-458
2009
Homo sapiens
brenda
Matsubayashi, H.; Sugi, T.; Suzuki, T.; Uchida, N.; Atsumi, H.; Izumi, S.; Mikami, M.
Decreased factor XII activity is associated with recurrent IVF-ET failure
Am. J. Reprod. Immunol.
59
316-322
2008
Homo sapiens
brenda
Barbasz, A.; Kozik, A.
The assembly and activation of kinin-forming systems on the surface of human U-937 macrophage-like cells
Biol. Chem.
390
269-275
2009
Homo sapiens
brenda
Lombardi, A.M.; Bortoletto, E.; Scarparo, P.; Scapin, M.; Santarossa, L.; Girolami, A.
Genetic study in patients with factor XII deficiency: a report of three new mutations exon 13 (Q501STOP), exon 14 (P547L) and -13C>T promoter region in three compound heterozygotes
Blood Coagul. Fibrinolysis
19
639-643
2008
Homo sapiens
brenda
Okorie, U.M.; Denney, W.S.; Chatterjee, M.S.; Neeves, K.B.; Diamond, S.L.
Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow
Blood
111
3507-3513
2008
Homo sapiens
brenda
Stoll, G.; Kleinschnitz, C.; Nieswandt, B.
Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment
Blood
112
3555-3562
2008
Homo sapiens, Mus musculus
brenda
Schousboe, I.; Nystrom, B.T.; Hansen, G.H.
Differential binding of factor XII and activated factor XII to soluble and immobilized fibronectin--localization of the Hep-1/Fib-1 binding site for activated factor XII
FEBS J.
275
5161-5172
2008
Homo sapiens
brenda
Schmaier, A.H.
The elusive physiologic role of Factor XII
J. Clin. Invest.
118
3006-3009
2008
Homo sapiens
brenda
Davis, A.E.; Mejia, P.; Lu, F.
Biological activities of C1 inhibitor
Mol. Immunol.
45
4057-4063
2008
Homo sapiens
brenda
Reuner, K.H.; Jenetzky, E.; Aleu, A.; Litfin, F.; Mellado, P.; Kloss, M.; Juettler, E.; Grau, A.J.; Rickmann, H.; Patscheke, H.; Lichy, C.
Factor XII C46T gene polymorphism and the risk of cerebral venous thrombosis
Neurology
70
129-132
2008
Homo sapiens
brenda
Kleinschnitz, C.; Braeuninger, S.; Pham, M.; Austinat, M.; Noelte, I.; Renne, T.; Nieswandt, B.; Bendszus, M.; Stoll, G.
Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis
Stroke
39
1262-1268
2008
Mus musculus
brenda
Melo, F.R.; Mourao, P.A.
An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases
Thromb. Haemost.
99
531-538
2008
Homo sapiens
brenda
Fonseca, R.J.; Oliveira, S.N.; Melo, F.R.; Pereira, M.G.; Benevides, N.M.; Mourao, P.A.
Slight differences in sulfation of algal galactans account for differences in their anticoagulant and venous antithrombotic activities
Thromb. Haemost.
99
539-545
2008
Rattus norvegicus
brenda
Fink, H.; Faxaelv, L.; Molnar, G.F.; Drotz, K.; Risberg, B.; Lindahl, T.L.; Sellborn, A.
Real-time measurements of coagulation on bacterial cellulose and conventional vascular graft materials
Acta Biomater.
6
1125-1130
2010
Homo sapiens
brenda
Vogler, E.A.; Siedlecki, C.A.
Contact activation of blood-plasma coagulation
Biomaterials
30
1857-1869
2009
Bos taurus, Equus caballus, Gallus gallus, Homo sapiens
brenda
Chatterjee, K.; Thornton, J.L.; Bauer, J.W.; Vogler, E.A.; Siedlecki, C.A.
Moderation of prekallkrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition
Biomaterials
30
4915-4920
2009
Homo sapiens
brenda
Bork, K.; Kleist, R.; Hardt, J.; Witzke, G.
Kallikrein-kinin system and fibrinolysis in hereditary angioedema due to factor XII gene mutation Thr309Lys
Blood Coagul. Fibrinolysis
20
325-332
2009
Homo sapiens
brenda
Kwon, M.J.; Kim, H.J.; Lee, K.O.; Jung, C.W.; Kim, S.H.
Molecular genetic analysis of Korean patients with coagulation factor XII deficiency
Blood Coagul. Fibrinolysis
21
308-312
2010
Homo sapiens (P00748), Homo sapiens
brenda
Papageorgiou, P.C.; Simos, D.; Boomsma, F.; Rojkjaer, R.; Osmond, D.H.
Angiotensin converting enzyme-regulated, noncholinergic sympathoadrenal catecholamine release mediates the cardiovascular actions of human new pressor protein related to coagulation beta-factor XIIa
Can. J. Cardiol.
25
e100-e108
2009
Homo sapiens
brenda
Kraft, P.; Schwarz, T.; Pochet, L.; Stoll, G.; Kleinschnitz, C.
COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke
Exp. Transl. Stroke Med.
2
5
2010
Mus musculus, Mus musculus C57BL/6
brenda
Wang, R.; Zhang, T.; Ma, Z.; Wang, Y.; Cheng, Z.; Xu, H.; Li, W.; Wang, X.
The interaction of coagulation factor XII and monocyte/macrophages mediating peritoneal metastasis of epithelial ovarian cancer
Gynecol. Oncol.
117
460-466
2010
Homo sapiens
brenda
Jablonska, E.; Markart, P.; Zakrzewicz, D.; Preissner, K.T.; Wygrecka, M.
Transforming growth factor-beta1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts
J. Biol. Chem.
285
11638-11651
2010
Homo sapiens
brenda
Chatterjee, K.; Guo, Z.; Vogler, E.; Siedlecki, C.
Contributions of contact activation pathways of coagulation factor XII in plasma
J. Biomed. Mater. Res. A
90
27-34
2009
Homo sapiens
brenda
Decrem, Y.; Rath, G.; Blasioli, V.; Cauchie, P.; Robert, S.; Beaufays, J.; Frere, J.M.; Feron, O.; Dogne, J.M.; Dessy, C.; Vanhamme, L.; Godfroid, E.
Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis
J. Exp. Med.
206
2381-2395
2009
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Pham, M.; Kleinschnitz, C.; Helluy, X.; Bartsch, A.J.; Austinat, M.; Behr, V.C.; Renne, T.; Nieswandt, B.; Stoll, G.; Bendszus, M.
Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI
Neuroimage
49
2907-2914
2010
Mus musculus
brenda
Suzuki, K.; Murai, K.; Suwabe, A.; Ishida, Y.
Factor XII Ofunato: Lys346Asn mutation associated with blood coagulation factor XII deficiency causes impaired secretion through a proteasome-mediated degradation
Thromb. Res.
125
438-443
2010
Homo sapiens
brenda
Bäck, J.; Sanchez, J.; Elgue, G.; Ekdahl, K.; Nilsson, B.
Activated human platelets induce factor XIIa-mediated contact activation
Biochem. Biophys. Res. Commun.
391
11-17
2010
Homo sapiens
brenda
Cheng, Q.; Tucker, E.; Pine, M.; Sisler, I.; Matafonov, A.; Sun, M.; White-Adams, T.; Smith, S.; Hanson, S.; McCarty, O.; Renne, T.; Gruber, A.; Gailani, D.
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo
Blood
116
3981-3989
2010
Mus musculus
brenda
MacQuarrie, J.L.; Stafford, A.R.; Yau, J.W.; Leslie, B.A.; Vu, T.T.; Fredenburgh, J.C.; Weitz, J.I.
Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation
Blood
117
4134-4141
2011
Homo sapiens
brenda
Pham, M.; Stoll, G.; Nieswandt, B.; Bendszus, M.; Kleinschnitz, C.
Blood coagulation factor XII-a neglected player in stroke pathophysiology
J. Mol. Med.
90
119-126
2011
Mus musculus, Mus musculus (P00748)
brenda
Iijima, K.; Arakawa, Y.; Sugahara, Y.; Matsushita, M.; Moriguchi, Y.; Shimohiro, H.; Nakagawa, M.
Factor XII Osaka: Abnormal factor XII with partially defective prekallikrein cleavage activity
Thromb. Haemost.
105
473-478
2011
Homo sapiens
brenda
Kuijpers, M.J.; van der Meijden, P.E.; Feijge, M.A.; Mattheij, N.J.; May, F.; Govers-Riemslag, J.; Meijers, J.C.; Heemskerk, J.W.; Renne, T.; Cosemans, J.M.
Factor XII regulates the pathological process of thrombus formation on ruptured plaques
Arterioscler. Thromb. Vasc. Biol.
34
1674-1680
2014
Homo sapiens, Mus musculus
brenda
Papageorgiou, P.C.; Yeo, E.L.; Backx, P.H.; Floras, J.S.
Activated plasma coagulation beta-factor XII-induced vasoconstriction in rats
Clin. Sci.
122
581-590
2012
Rattus norvegicus
brenda
Van Der Meijden, P.E.; Van Schilfgaarde, M.; Van Oerle, R.; Renne, T.; ten Cate, H.; Spronk, H.M.
Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa
J. Thromb. Haemost.
10
1355-1362
2012
Homo sapiens
brenda
Puy, C.; Tucker, E.I.; Wong, Z.C.; Gailani, D.; Smith, S.A.; Choi, S.H.; Morrissey, J.H.; Gruber, A.; McCarty, O.J.
Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates
J. Thromb. Haemost.
11
1341-1352
2013
Homo sapiens (P00748)
brenda
Sylman, J.; Daalkhaijav, U.; Zhang, Y.; Gray, E.; Farhang, P.; Chu, T.; Zilberman-Rudenko, J.; Puy, C.; Tucker, E.; Smith, S.; Morrissey, J.; Walker, T.; Nan, X.; Gruber, A.; McCarty, O.
Differential roles for the coagulation factors XI and XII in regulating the physical biology of fibrin
Ann. Biomed. Eng.
45
1328-1340
2017
Homo sapiens
brenda
Ivanov, I.; Matafonov, A.; Sun, M.F.; Cheng, Q.; Dickeson, S.K.; Verhamme, I.M.; Emsley, J.; Gailani, D.
Proteolytic properties of single-chain factor XII a mechanism for triggering contact activation
Blood
129
1527-1537
2017
Homo sapiens
brenda
Dementiev, A.; Silva, A.; Yee, C.; Li, Z.; Flavin, M.T.; Sham, H.; Partridge, J.R.
Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors
Blood Adv.
2
549-558
2018
Homo sapiens (P00748), Homo sapiens
brenda
Didiasova, M.; Wujak, L.; Schaefer, L.; Wygrecka, M.
Factor XII in coagulation, inflammation and beyond
Cell. Signal.
51
257-265
2018
Mus musculus
brenda
Ivanov, I.; Matafonov, A.; Gailani, D.
Single-chain factor XII a new form of activated factor XII
Curr. Opin. Hematol.
24
411-418
2017
Homo sapiens
brenda
Wujak, L.; Didiasova, M.; Zakrzewicz, D.; Frey, H.; Schaefer, L.; Wygrecka, M.
Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface
J. Biol. Chem.
290
7027-7039
2015
Homo sapiens
brenda
Stroo, I.; Zeerleder, S.; Ding, C.; Luken, B.M.; Roelofs, J.J.T.H.; de Boer, O.J.; Meijers, J.C.M.; Castellino, F.J.; van t Veer, C.; van der Poll, T.
Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation
Thromb. Haemost.
117
1601-1614
2017
Mus musculus
brenda
Hess, R.; Wujak, L.; Hesse, C.; Sewald, K.; Jonigk, D.; Warnecke, G.; Fieguth, H.G.; de Maat, S.; Maas, C.; Bonella, F.; Preissner, K.T.; Weiss, B.; Schaefer, L.; Kuebler, W.M.; Markart, P.; Wygrecka, M.
Coagulation factor XII regulates inflammatory responses in human lungs
Thromb. Haemost.
117
1896-1907
2017
Homo sapiens
brenda
Konings, J.; Hoving, L.R.; Ariens, R.S.; Hethershaw, E.L.; Ninivaggi, M.; Hardy, L.J.; de Laat, B.; Ten Cate, H.; Philippou, H.; Govers-Riemslag, J.W.
The role of activated coagulation factor XII in overall clot stability and fibrinolysis
Thromb. Res.
136
474-480
2015
Homo sapiens
brenda