Literature summary for 3.4.21.38 extracted from

Chatterjee, K.; Thornton, J.L.; Bauer, J.W.; Vogler, E.A.; Siedlecki, C.A.
Moderation of prekallkrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition (2009), Biomaterials, 30, 4915-4920.

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Protein Variants

Protein Variants	Comment	Organism
additional information	usage of measurement of prekallkrein hydrolysis to kallikrein by activated factor XII at test hydrophilic clean glass and hydrophobic silanized glass surfaces in the presence of bovine serum albumin, BSA. Activation after contact of the zymogen FXII with a test hydrophobic surface to activated FXII occurs only if putatively adsorbed FXIIa is competitively displaced by BSA, model for the sequence of events involving prekallikrein and FXII at solid procoagulant surfaces, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
prekallikrein + H2O	Homo sapiens	-	kallikrein + kallikrein prepeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	activation of zymogen FXII to FXIIa by autoactivation	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	usage of measurement of prekallkrein hydrolysis to kallikrein by activated factor XII at test hydrophilic clean glass and hydrophobic silanized glass surfaces in the presence of bovine serum albumin, BSA. Activation after contact of the zymogen FXII with a test hydrophobic surface to activated FXII occurs only if putatively adsorbed FXIIa is competitively displaced by BSA, overview. An anionic hydrophilic surface is not a necessary cofactor for FXIIa-mediated hydrolysis of PK, and PK hydrolysis does not need to occur by an activation complex assembled directly on an anionic, activating surface. Contact activation of FXII (autoactivation) is not specific to anionic hydrophilic surfaces. Protein-adsorption competition is an essential feature that must be included in any comprehensive mechanism of surface-induced blood coagulation. Activation of zymogen FXII to FXIIa by autoactivation	Homo sapiens	?	-	?
prekallikrein + H2O	-	Homo sapiens	kallikrein + kallikrein prepeptide	-	?

Synonyms

Synonyms	Comment	Organism
activated factor XII	-	Homo sapiens
FXIIa	-	Homo sapiens

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Release 2023.1 (January 2023)