3.4.17.2: carboxypeptidase B

This is an abbreviated version!
For detailed information about carboxypeptidase B, go to the full flat file.

Word Map on EC 3.4.17.2

Reaction

preferential release of a C-terminal lysine or arginine amino acid =

Synonyms

More, TAFI, EC 3.4.2.2, EC 3.4.12.3, protaminase, carboxypeptidase BII, CPB, Cbp, 47 kDa zymogen granule membrane associated protein, Pancreas-specific protein, PASP, ZAP47, PCB, CPB1, thrombin-activatable fibrinolysis inhibitor, HBCPB, PcpB, aCAP, tissue carboxypeptidase B, basic carboxypeptidase, pp-CpB, B carboxypeptidase, CPBAg1, CPB2, carboxypeptidase B, thrombin-activatable procarboxypeptidase B, Carboxypeptidase B1, HzCPB, cpbAs1, ppCPB, carboxypeptidase B2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.2 carboxypeptidase B

Natural Substrates Products

Natural Substrates Products on EC 3.4.17.2 - carboxypeptidase B

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Fibrin + H2O
?
show the reaction diagram
-
CPB activity generates fine-mesh fibrin which is more difficult to lyse by tPA
-
-
?
human proinsulin + H2O
?
show the reaction diagram
-
enzymatic modification of human proinsulin using trypsin and carboxypeptidase B generally causes high accumulation of insulin derivatives, leading to more complicated purification processes. A simple method including citraconylation and decitraconylation in the enzymatic modification process is developed for the reduction of a major derivative, des-threonine human insulin
-
-
?
OPN-R + H2O
OPN-L + ?
show the reaction diagram
-
osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L
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-
?
additional information
?
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