3.4.17.2: carboxypeptidase B
This is an abbreviated version!
For detailed information about carboxypeptidase B, go to the full flat file.
Word Map on EC 3.4.17.2
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3.4.17.2
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cardiopulmonary
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cardiac
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artery
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postoperative
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coronary
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aortic
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perioperative
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myocardial
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pulmonary
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ventricular
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hemodynamic
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heparin
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transfusion
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elective
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circuit
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intraoperative
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valve
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bleeding
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hypothermic
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anesthesia
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venous
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extracorporeal
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ventilation
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protamine
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inotropic
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cardioplegia
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sternotomy
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rewarming
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hemodilution
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revascularization
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cross-clamping
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atrial
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normothermic
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wean
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hematocrit
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circulatory
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off-pump
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analysis
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cardiothoracic
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synthesis
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intra-aortic
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medicine
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open-heart
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thoracotomy
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in-hospital
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drug development
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extubation
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pharmacology
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crystalloid
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cannulation
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roller
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transesophageal
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fentanyl
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antegrade
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reoperation
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diagnostics
- 3.4.17.2
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cardiopulmonary
- cardiac
- artery
-
postoperative
- coronary
- aortic
-
perioperative
- myocardial
- pulmonary
- ventricular
-
hemodynamic
- heparin
-
transfusion
-
elective
-
circuit
-
intraoperative
- valve
-
bleeding
-
hypothermic
-
anesthesia
- venous
-
extracorporeal
-
ventilation
- protamine
-
inotropic
-
cardioplegia
-
sternotomy
-
rewarming
-
hemodilution
-
revascularization
-
cross-clamping
- atrial
-
normothermic
-
wean
-
hematocrit
-
circulatory
-
off-pump
- analysis
-
cardiothoracic
- synthesis
-
intra-aortic
- medicine
-
open-heart
-
thoracotomy
-
in-hospital
- drug development
-
extubation
- pharmacology
- crystalloid
-
cannulation
-
roller
-
transesophageal
-
fentanyl
-
antegrade
-
reoperation
- diagnostics
Reaction
preferential release of a C-terminal lysine or arginine amino acid =
Synonyms
47 kDa zymogen granule membrane associated protein, aCAP, B carboxypeptidase, basic carboxypeptidase, carboxypeptidase B, Carboxypeptidase B1, carboxypeptidase B2, carboxypeptidase BII, Cbp, CPB, CPB1, CPB2, CPBAg1, cpbAs1, EC 3.4.12.3, EC 3.4.2.2, HBCPB, HzCPB, More, Pancreas-specific protein, PASP, PCB, PcpB, pp-CpB, ppCPB, protaminase, TAFI, thrombin-activatable fibrinolysis inhibitor, thrombin-activatable procarboxypeptidase B, tissue carboxypeptidase B, ZAP47
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General Information
General Information on EC 3.4.17.2 - carboxypeptidase B
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malfunction
metabolism
physiological function
anti-CPBAs1 directed antibodies can significantly reduce the mosquito infection rate in the test group compared with the control group
malfunction
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Cpb2 knockout mice develop greater cartilage damage than wild-type mice and have a greater number of osteophytes and degree of synovitis
malfunction
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Cpb2 knockout mice develop greater cartilage damage than wild-type mice and have a greater number of osteophytes and degree of synovitis
malfunction
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among mice genetically deficient in either carboxypeptidase B2 (Cpb2) or carboxypeptidase N (Cpn), in a model of hemolytic-uremic syndrome, Cpb2-/- mice have the worst disease, followed by Cpn-/- mice, with wild-type mice being the most protected. This model is driven by C5a, and shows that carboxypeptidase B2 is important in inactivating C5a. Cpn-/- mice are generated by disruption of Cpn1. When mice are challenged acutely with cobra venom factor, the reverse phenotype is observed. Cpn-/- mice have markedly worse disease than Cpb2-/- mice, and wild-type mice are resistant
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nitrone spin-trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and a combination of immuno-spin trapping and mass spectrometry is used to identify in vivo products of radical reactions in mice. Dose-dependent production of 5,5-dimethyl-1-pyrroline N-oxide-CPB1 adducts are detected in the spleens of mice treated with lipopolysaccharide and also under normal physiological conditions. Treatments with inhibitors and experiments with knock-out mice indicate that xanthine oxidase and endothelial nitric oxide synthase are important sources of the reactive species that lead to CPB1 adduct formation
metabolism
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CPB activity generates fine-mesh fibrin which is more difficult to lyse by tPA but conversely, CPB and plasmin together can stimulate fibrinolysis
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carboxypeptidase B activity is not affected by Zn supplementation
physiological function
in contrast to botulinum neurotoxin carboxypeptidase is not affected by mechanical stirring
physiological function
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thrombin-activatable CPB plays a central homeostatic role in rheumatoid arthritis by regulating neutrophil viability and reducing synoviocyte adhesion
physiological function
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thrombomodulin suppresses pericellular fibrinolysis and plasma-induced tumor cell invasion, which is mediated by plasma TAFI activation
physiological function
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the enzyme delays fibrinolysis. CPB2 is important in inactivating C5a
physiological function
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the enzyme removes C-terminal basic amino acids from bioactive peptides and proteins, thereby inactivating them