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Literature summary for 3.4.17.2 extracted from

  • Sharif, S.A.; Du, X.; Myles, T.; Song, J.J.; Price, E.; Lee, D.M.; Goodman, S.B.; Nagashima, M.; Morser, J.; Robinson, W.H.; Leung, L.L.
    Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis (2009), Arthritis Rheum., 60, 2902-2912.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.2

Activating Compound

Activating Compound Comment Organism Structure
thrombin
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antithrombomodulin antibody
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
 Western blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
OPN-R + H2O Homo sapiens osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L OPN-L + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
synoviocyte fibroblast-like synoviocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
OPN-R + H2O osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L Homo sapiens OPN-L + ?
-
 ?

Synonyms

Synonyms Comment Organism
PcpB
-
 Homo sapiens
thrombin-activatable fibrinolysis inhibitor
-
 Homo sapiens
thrombin-activatable procarboxypeptidase B
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function thrombin-activatable CPB plays a central homeostatic role in rheumatoid arthritis by regulating neutrophil viability and reducing synoviocyte adhesion Homo sapiens