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1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.7

Reaction

2 glutathione +

NADP+
=
glutathione disulfide
 +
NADPH
 +
H+

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.7 glutathione-disulfide reductase

Activating Compound

Activating Compound on EC 1.8.1.7 - glutathione-disulfide reductase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
abscisic acid
-
0.1 mM, significant enhancement of activity 24 h after treatment
alpha-crystallin
-
2 mg/ml causes 37% increase in activity, 1 mg/ml causes 20% enhancement
-
amikacin
-
-
amoxicillin
-
-
ampicillin
-
leads to slight activation in vivo
cadmium
-
100 mM, 111% and 100% enhancement of enzyme activity in root tissue after 7 and 14 days, respectively
captopril
-
5-10 mM, the best enhancement (30%) is achieved using 10 mM
clindamycin
-
-
cysteine
DL-dithiothreitol
-
0.25-4 mM, the best enhancement of activity (96.6%) is obtained by a concentration of 1 mM
doxorubicin
-
differences between drug-sensitive and drug-resistant cells, overview
FAD analogues
-
gentamycin sulfate
-
leads to slight activation in vivo
GSH
-
0.25 mM, 37% enhancement of activity
H2O2
increases enzyme activity
Lincomycin
-
-
Melatonin
NaBr
-
non-linear
NADP+
-
stimulates
NADPH
-
substrate inhibition by excess of NADPH
Nicotine
-
0.5 mg/kg, 11.8% enhancement of enzymatic activity in brain
penicillin G
-
leads to slight activation in vivo
phenanthrene
-
exposure to 0.5 microM phenanthrene results in significant increases in the levels of both enzymatic and non-enzymatic antioxidants, with the levels of total glutathione and ascorbate doubling, and the activities of GR increasing by 20fold after 72 h of exposure to PHEN
Selenite
-
4fold increase in activity in U-1256 cells, less pronounced in presence of doxorubicin, differences between drug-sensitive and drug-resistant cells, overview
Sodium acetate
-
non-linear
Sodium citrate
-
non-linear
Sodium phosphate
streptomycin sulfate
-
leads to slight activation in vivo
teicoplanin
-
leads to slight activation in vivo
Thiamphenicol
-
leads to slight activation in vivo
thioltransferase
-
1 unit, 43% enhancement of activity
-
additional information
-