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Literature summary for 1.8.1.7 extracted from
- Characterization of human platelet glutathione reductase (1978), Biochim. Biophys. Acta, 527, 327-336.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NaBr | non-linear | Homo sapiens |  |
| NaCl | non-linear | Homo sapiens | |
| Sodium acetate | non-linear | Homo sapiens | |
| Sodium citrate | non-linear | Homo sapiens | |
| Sodium phosphate | activates at sub-saturating concentrations, linear | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FMN | - |
Homo sapiens | |
| NaBr | above 0.2 M | Homo sapiens | |
| NADP+ | - |
Homo sapiens | |
| Nitrofurantoin | non-competitive | Homo sapiens | |
| riboflavin | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaBr | activates | Homo sapiens | |
| NaCl | activates | Homo sapiens | |
| Sodium acetate | activates | Homo sapiens | |
| Sodium citrate | activates | Homo sapiens | |
| Sodium phosphate | activates | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSSG + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 7.6 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | FAD enzyme | Homo sapiens | |
| NADH | 2% activity of that with NADPH | Homo sapiens | |
| NADPH | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
Nitrofurantoin | platelets | Homo sapiens | |
| 0.004 | - |
FMN | - |
Homo sapiens | |
| 0.02 | - |
riboflavin | - |
Homo sapiens | |
| 0.028 | - |
NADP+ | 10 mM sodium phosphate | Homo sapiens | |
| 0.05 | - |
FAD | - |
Homo sapiens | |
| 0.06 | - |
NADP+ | 0.1 M sodium phosphate | Homo sapiens | |
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