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1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.7

Reaction

2 glutathione +

NADP+
=
glutathione disulfide
 +
NADPH
 +
H+

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.7 glutathione-disulfide reductase

Substrates Products

Substrates Products on EC 1.8.1.7 - glutathione-disulfide reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(Z)-ajoene + NADPH + H+
4,5,9-trithiadodeca-1,6,11-triene + 4,8,9,13-tetrathiahexadeca-1,6,10,15-tetraene + NADP+
show the reaction diagram
-
-
-
-
r
1,4-dihydroxy-9,10-anthraquinone + NADPH
?
show the reaction diagram
1,4-naphthoquinone + NADPH + H+
?
show the reaction diagram
1,8-dihydroxy-9,10-anthraquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
2 ajoene + 4 NADPH + 4 H+
4,8,9,13-tetrathiahexadeca-1,6,1,15-tetraene + 4 NADP+ + 2 allylmercaptan
show the reaction diagram
2,3-dimethylquinoxaline-5,8-dione + NADPH + H+
?
show the reaction diagram
2,5-bis(aziridin-1-yl)-3,6-dimethylcyclohexa-2,5-diene-1,4-dione + NADPH
?
show the reaction diagram
-
-
-
-
?
2,5-bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione + NADPH
?
show the reaction diagram
-
-
-
-
?
2,5-bis(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione + NADPH
?
show the reaction diagram
-
-
-
-
?
2,5-bis(ethylamino)-3,6-di(aziridinyl)-1,4-benzoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
2,6-dimethyl-1,4-benzoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
2-hydroxy-1,4-naphthoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
2-hydroxy-3-methyl-1,4-naphthoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
2-methyl-1,4-naphthoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
show the reaction diagram
-
-
-
-
?
5,8-dihydroxy-1,4-naphthoquinone + NADPH
?
show the reaction diagram
5-hydroxy-1,4-naphthoquinone + NADPH
?
show the reaction diagram
6,7-dimethylquinoline-5,8-dione + NADPH + H+
?
show the reaction diagram
6-methylquinoline-5,8-dione + NADPH + H+
?
show the reaction diagram
7-methylquinoline-5,8-dione + NADPH + H+
?
show the reaction diagram
9,10-phenanthrene quinone + NADPH
?
show the reaction diagram
-
-
-
-
?
ajoene + NADPH + H+
4,5,9-trithiadodeca-1,6,11-triene + NADP+ + H2O
show the reaction diagram
AuCl4- + NADPH + H+
?
show the reaction diagram
-
formation of gold nanoparticles at the active site of glutathione reductase that are tightly bound through the catalytic cysteines. The nanoparticles can be removed from the glutathione reductase active site with thiol reagents such as 2-mercaptoethanol
-
-
?
bis-N,N'-(gamma-glutamylcystine) + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
bis-N-chloro-gamma-L-glutamyl derivative of GSSG + NADPH + H+
? + glutathione + NADP+
show the reaction diagram
-
-
-
-
?
diallyl trisulfide + NADPH
?
show the reaction diagram
-
-
-
-
?
diethyl [2,5-bis(aziridin-1-yl)-3,6-dioxocyclohexa-1,4-diene-1,4-diyl]biscarbamate + NADPH
?
show the reaction diagram
-
-
-
-
?
ferricyanide + NADPH + H+
ferrocyanide + NADP+
show the reaction diagram
-
-
-
-
r
glutathione + NADP+
glutathione disulfide + NADPH + H+
show the reaction diagram
glutathione disulfide + NADH + H+
2 glutathione + NAD+
show the reaction diagram
-
-
-
?
glutathione disulfide + NADH + H+
glutathione + NAD+
show the reaction diagram
glutathione disulfide + NADPH
glutathione + NADP+
show the reaction diagram
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
show the reaction diagram
glutathione disulfide + NADPH + H+
glutathione + NADP+
show the reaction diagram
glutathione-S-sulfonate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
GSSG + NADPH
glutathione + NADP+
show the reaction diagram
GSSG + NADPH + H+
glutathione + NADP+
show the reaction diagram
GSSG + NADPH + H+
GSH + NADP+
show the reaction diagram
menadione + NADPH + H+
?
show the reaction diagram
peroxynitrite + NADPH
nitrite + H2O + NADP+
show the reaction diagram
quinoline-5,8-dione + NADPH + H+
?
show the reaction diagram
quinoxaline-5,8-dione + NADPH + H+
?
show the reaction diagram
S-allylmercaptoglutathione disulfide + NADPH + H+
2 S-allylmercaptoglutathione + NADP+
show the reaction diagram
S-nitrosoglutathione + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
tetramethyl-1,4-benzoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
trimethyl-1,4-benzoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
trimethyl-aziridinyl-1,4-benzoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
trypanothione + NADPH
reduced trypanothione + NADP+
show the reaction diagram
additional information
?
-