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Literature summary for 1.8.1.7 extracted from
- Effects of nicotine and vitamin E on glutathione reductase activity in some rat tissues in vivo and in vitro (2007), Eur. J. Pharmacol., 554, 92-97.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Nicotine | 0.5 mg/kg, 11.8% enhancement of enzymatic activity in brain | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | vitamin E restores the inhibition of glutathione reductase due to nicotine administration in liver, lung, heart, stomach and kidney tissue, but not in testicle tissue | Rattus norvegicus | |
| Nicotine | 0.5 mg/kg, significant inhibition of enzymatic activity in liver (61.5%), lung (65%), heart (70.5%), stomach (72.5%), kidney (64%) and testicle (71.5%) | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate fractionation, 2',5'-ADP Sepharose 4B affinity chromatography and Sephadex G-200 gel filtration | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| stomach | - |
Rattus norvegicus | - |
| testicle | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione reductase | - |
Rattus norvegicus |
| glutathione: NADP(+) oxidoreductase | - |
Rattus norvegicus |
| GR | - |
Rattus norvegicus |
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