Reference on EC 1.8.1.7 - glutathione-disulfide reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Krauth-Siegel, R.L.; Mueller, J.G.; Lottspeich, F.; Schirmer, R.H.
Glutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria
Eur. J. Biochem.
235
345-350
1996
Plasmodium falciparum
Williams, C.H.
Flavin-containing dehydrogenases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
13
89-173
1976
Saccharomyces cerevisiae, Escherichia coli, Hemicentrotus pulcherrimus, Homo sapiens, Penicillium chrysogenum, Rattus norvegicus
-
Schirmer, R.H.; Krauth-Siegel, R.L.; Schulz, G.E.
Glutathione reductase
Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York
3
553-596
1989
Allochromatium vinosum, Bos taurus, Saccharomyces cerevisiae, Bufo bufo, Oryctolagus cuniculus, Escherichia coli, Meriones unguiculatus, Homo sapiens, Litomosoides carinii, Scombridae, Mus musculus, Penicillium chrysogenum, Plasmodium vinckei, Rattus norvegicus, Spinacia oleracea, Sus scrofa
-
Colman, R.F.
Glutathione reductase (yeast)
Methods Enzymol.
17
500-503
1971
Saccharomyces cerevisiae
-
Williams, C.H.; Arscott, L.D.
Glutathione reductase (Escherichia coli)
Methods Enzymol.
17
503-509
1971
Escherichia coli
-
Carlberg, I.; Mannervik, B.
Glutathione reductase
Methods Enzymol.
113
484-490
1985
Bos taurus, Rattus norvegicus
Moroff, G.; Kosow, D.P.
Characterization of human platelet glutathione reductase
Biochim. Biophys. Acta
527
327-336
1978
Homo sapiens
Ruiz-Herrera, J.; Amezcua-Ortega, R.; Trujillo, A.
Purification and properties of a disulfide reductase obtained from Achromobacter starkeyi
J. Biol. Chem.
243
4083-4088
1968
Achromobacter starkeyi
Schulz, G.E.; Schirmer, R.H.; Pai, E.F.
The three-diemensional structure of glutathione reductase and its substrate complexes at 0.3 nm resolution
Flavins and Flavoproteins (Proc. Int. Symp. , 6th, Meeting, Yagi, K. , Yamano, T. , eds. )
557-567
1978
Homo sapiens
-
Scrutton, N.S.; Berry, A.; Perham, R.N.
Purification and characterization of glutathione reductase encoded by a cloned and over-expressed gene in Escherichia coli
Biochem. J.
245
875-880
1987
Escherichia coli
Kidambi, S.P.; Mahan, J.R.; Matches, A.G.
Purification and thermal dependence of glutathione reductase from two forage legume species
Plant Physiol.
92
363-367
1990
Medicago sativa, Onobrychis viciifolia
Acan, N.L.; Tezcan, E.F.
Sheep brain glutathione reductase: purification and general properties
FEBS Lett.
250
72-74
1989
Ovis aries
Wong, K.K.; Vanoni, M.A.; Blanchard, J.S.
Glutathione reductase: solvent equilibrium and kinetic isotope effects
Biochemistry
27
7091-7096
1988
Saccharomyces cerevisiae, Homo sapiens, Spinacia oleracea
Montero, S.; De Arriaga, D.; Soler, J.
Purification and characterization of glutathione reductase from mycelium of Phycomyces blakesleeanus
Biochim. Biophys. Acta
952
56-66
1988
Phycomyces blakesleeanus
-
Shigeoka, S.; Onishi, T.; Nakano, Y.; Kitaoka, S.
Characterization and physiological function of glutathione reductase in Euglena gracilis z
Biochem. J.
242
511-515
1987
Euglena gracilis, Euglena gracilis Z
Boggaram, V.; Brobjer, T.; Larson, K.; Mannervik, B.
Purification of glutathione reductase from porcine erythrocytes by the use of affinity chromatography on 2,5-ADP-Sepharose 4B and crystallization of the enzyme
Anal. Biochem.
98
335-340
1979
Sus scrofa
Boggaram, V.; Larson, K.; Mannervik, B.
Characterization of glutathione reductase from porcine erythrocytes
Biochim. Biophys. Acta
527
337-347
1978
Sus scrofa
Harding, J.J.
Affinity chromatography in the purification of glutathione reductase
J. Chromatogr.
77
191-199
1973
Saccharomyces cerevisiae, Ovis aries, Homo sapiens, Triticum aestivum
Worthington, D.J.; Rosemeyer, M.A.
Human glutathione reductase: purification of the crystalline enzyme from erythrocytes
Eur. J. Biochem.
48
167-177
1974
Homo sapiens
Worthington, D.J.; Rosemeyer, M.A.
Glutathione reductase from human erythrocytes. Catalytic properties and aggregation
Eur. J. Biochem.
67
231-238
1976
Homo sapiens
Worthington, D.J.; Rosemeyer, M.A.
Glutathione reductase from human erythrocytes. Molecular weight, subunit composition and aggregation properties
Eur. J. Biochem.
60
459-466
1975
Homo sapiens
Nakashima, K.; Miwa, S.; Yamauchi, K.
Human erythrocyte glutathione reductase. I. Purification and properties
Biochim. Biophys. Acta
445
309-323
1976
Homo sapiens
Krohne-Ehrich, G.; Schirmer, R.H.; Untucht-Grau, R.
Glutathione reductase from human erythrocytes
Eur. J. Biochem.
80
65-71
1971
Homo sapiens
Untucht-Grau, R.; Schirmer, R.H.; Schirmer, I.; Krauth-Siegel, R.L.
Glutathione reductase from human erythrocytes: amino-acid sequence of the structurally known FAD-binding domain
Eur. J. Biochem.
120
407-419
1981
Homo sapiens
Krauth-Siegel, R.L.; Schirmer, R.H.; Ghisla, S.
FAD analogues as prosthetic groups of human glutathione reductase. Properties of the modified enzyme species and comparisons with the active site structure
Eur. J. Biochem.
148
335-344
1985
Homo sapiens
Connell, J.P.; Mullet, J.E.
Pea chloroplast glutathione reductase: purification and characterization
Plant Physiol.
82
351-356
1986
Pisum sativum
Bielawski, W.; Joy, K.W.
Properties of glutathione reductase from chloroplasts and roots of pea
Phytochemistry
25
2261-2265
1986
Pisum sativum
-
Rendon, J.L.; Calcagno, M.; Mendoza-Hernandez, G.; Ondarza, R.N.
Purification, properties, and oligomeric structure of glutathione reductase from the cyanobacterium Spirulina maxima
Arch. Biochem. Biophys.
248
215-223
1986
Limnospira maxima
Zanetti, G.
Rabbit liver glutathione reductase. Purification and properties
Arch. Biochem. Biophys.
198
241-246
1979
Oryctolagus cuniculus
Zanetti, G.; Beretta, C.; Malandra, D.
Properties of rabbit liver glutathione reductase reconstituted with FAD analogs
Arch. Biochem. Biophys.
244
831-837
1986
Oryctolagus cuniculus
Malaisse, W.J.; Dufrane, S.P.; Mathias, P.C.F.; Carpinelli, A.R.; Malaisse-Lagae, F.; Garcia-Morales, P.; Valverde, I.; Sener, A.
The coupling of metabolic to secretory events in pancreatic islets. The possible role of glutathione reductase
Biochim. Biophys. Acta
844
256-264
1985
Rattus norvegicus
Mata, A.M.; Pinto, M.C.
Purification by affinity chromatography of glutathione reductase (EC 1.6.4.2) from Escherichia coli and characterization of such enzyme
Z. Naturforsch. C
39
908-915
1984
Escherichia coli, Escherichia coli S33
Ermler, U.; Schulz, G.E.
The three-dimensional structure of glutathione reductase from Escherichia coli at 3.0 A resolution
Proteins Struct. Funct. Genet.
9
174-179
1991
Escherichia coli
Carlberg, I.; Altmejd, B.; Mannervik, B.
Purification and immunological studies of glutathione reductase from rat liver. Evidence for an antigenic determinant at the nucleotide-binding domain of the enzyme
Biochim. Biophys. Acta
677
146-152
1981
Rattus norvegicus
Le Trang, N.; Bhargava, K.K.; Cerami, A.
Purification of glutathione reductase from gerbil liver in two steps
Anal. Biochem.
133
94-99
1983
Meriones unguiculatus
Serrano, A.; Rivas, J.; Losada, M.
Purification and properties of glutathione reductase from the cyanobacterium Anabaena sp. strain 7119
J. Bacteriol.
158
317-324
1984
Anabaena sp., Anabaena sp. 7119
Carlberg, I.; Mannervik, B.
Purification and characterization of glutathione reductase from calf liver. An improved procedure for affinity chromatography on 2,5-ADP-Sepharose 4B
Anal. Biochem.
116
531-536
1981
Bos taurus
Lopez-Barea, J.; Lee, C.Y.
Mouse-liver glutathione reductase. Purification, kinetics, and regulation
Eur. J. Biochem.
98
487-499
1979
Mus musculus
Wirth, E.; Latzko, E.
Partial purification and properties of spinach leaf glutathione reductase
Z. Pflanzenphysiol.
89
69-75
1978
Spinacia oleracea
-
Halliwell, B.; Foyer, C.H.
Properties and physiological function of a glutathione reductase purified from spinach leaves by affinity chromatography
Planta
139
9-17
1978
Spinacia oleracea
Carlberg, I.; Mannervik, B.
Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione
Biochim. Biophys. Acta
484
268-274
1977
Saccharomyces cerevisiae
Pigiet, V.P.; Conley, R.R.
Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography
J. Biol. Chem.
252
6367-6372
1977
Escherichia coli, Escherichia coli 11
Tano, T.; Ishii, K.; Sugio, T.; Imai, K.
A NADPH:glutathione oxidoreductase isolated from Thiobacillus thiooxidans
Agric. Biol. Chem.
40
1879-1880
1976
Acidithiobacillus thiooxidans
-
Mannervik, B.; Jacobsson, K.; Boggaram, V.
Purification of glutathione reductase from erythrocytes by the use of affinity chromatography on 2, 5-ADP-Sepharose 4-B
FEBS Lett.
66
221-224
1976
Sus scrofa
Carlberg, I.; Mannervik, B.
Purification and characterization of the flavoenzyme glutathione reductase from rat liver
J. Biol. Chem.
250
5475-5480
1975
Rattus norvegicus
Chung, Y.C.; Hurlbert, R.E.
Purification and properties of the glutathione reductase of Chromatium vinosum
J. Bacteriol.
123
203-211
1975
Allochromatium vinosum
Ii, I.; Sakai, H.
Glutathione reductase in the sea urchin egg. I. Purification and general properties
Biochim. Biophys. Acta
350
141-150
1974
Hemicentrotus pulcherrimus
Ida, S.; Morita, Y.
Studies on respiratory enzymes in rice kernel. Part VII. Purification of an acidic flavoprotein, glutathione reductase, from rice embryos
Agric. Biol. Chem.
35
1542-1549
1971
Oryza sativa
-
Ida, S.; Morita, Y.
Studies on respiratory enzymes in rice kernel. Part VIII. Enzymatic properties and physical and chemical characterization of glutathione reductase from rice embryos
Agric. Biol. Chem.
35
1550-1557
1971
Oryza sativa
-
Boll, M.
Glutathione reductase from Rhodospirillum rubrum
Arch. Mikrobiol.
66
374-388
1969
Rhodospirillum rubrum
McCallum, M.J.; Barrett, J.
The purification and properties of glutathione reductase from the cestode Moniezia expansa
Int. J. Biochem. Cell Biol.
27
393-401
1995
Moniezia expansa
Garcia-Alfonso, C.; Martinez-Galisteo, E.; Llobell, A.; Barcena, J.A.; Lopez-Barea, J.
Horse-liver glutathione reductase: purification and characterization
Int. J. Biochem.
25
61-68
1993
Equus caballus
Hausladen, A.; Alscher, R.G.
Cold-hardiness-specific glutathione reductase isoenzymes in red spruce. Thermal dependence of kinetic parameters and possible regulatory mechanisms
Plant Physiol.
105
215-223
1994
Picea rubens
Serrano, A.; Llobell, A.
Occurrence of two isoforms of glutathione reductase in the green alga Chlamydomonas reinhardtii
Planta
190
199-205
1993
Chlamydomonas reinhardtii
-
Bohme, C.C.; Arscott, L.D.; Becker, K.; Schirmer, R.H.; Williams, C.H., Jr.
Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme
J. Biol. Chem.
275
37317-37323
2000
Plasmodium falciparum
Cunningham, M.L.; Zvelebil, M.J.J.M.; Fairlamb, A.H.
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
Eur. J. Biochem.
221
285-295
1994
Bos taurus, Homo sapiens, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense
Nordhoff, A.; Tziatzios, C.; van den Broek, J.A.; Schott, M.K.; Kalbitzer, H.R.; Becker, K.; Schubert, D.; Schirmer, R.H.
Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors
Eur. J. Biochem.
245
273-282
1997
Homo sapiens
Levron, B.; Burgot, G.; Burgot, J.L.
On the reduction of dithiolethiones and dithiolylium ions by NADPH and glutathione reductase
Arch. Biochem. Biophys.
382
189-194
2000
Saccharomyces cerevisiae
Takeda, T.; Ishikawa, T.; Shigeoka, S.; Hirayama, O.; Mitsunaga, T.
Purification and characterization of glutathione reductase from Chlamydomonas reinhardtii
J. Gen. Microbiol.
139
2233-2238
1993
Chlamydomonas reinhardtii
-
Pandey, A.; Iyengar, L.; Katiyar, S.S.
Modification of an essential amino group of glutathione reductase from yeast by pyridoxal 5'-phosphate
J. Enzyme Inhib.
12
143-154
1997
Saccharomyces cerevisiae
Jiang, F.; Mannervik, B.
Optimized heterologous expression of glutathione reductase from cyanobacterium Anabaena PCC 7120 and characterization of the recombinant protein
Protein Expr. Purif.
15
92-98
1999
Anabaena sp.
Francescutti, D.; Baldwin, J.; Lee, L.; Mutus, B.
Peroxynitrite modification of glutathione reductase: modeling studies and kinetic evidence suggest the modification of tyrosines at the glutathione disulfide binding site
Protein Eng.
9
189-194
1996
Bos taurus
Iio, M.; Kawaguchi, H.; Sakota, Y.; Otonari, J.; Nitahara, H.
Effects of polyphenols, including flavonoids, on glutathione S-transferase and glutathione reductase
Biosci. Biotechnol. Biochem.
57
1678-1680
1993
Bos taurus
-
Miki, T.; Tsujimoto, Y.; Miyabe, S.; Sugiyama, K.i.; Izawa, S.; Inoue, Y.; Kimura, A.
Oxidative stress response in yeast: purification and characterization of glutathione reductase from Hansenula mrakii
Biosci. Biotechnol. Biochem.
60
1207-1209
1996
Cyberlindnera mrakii
Sugio, T.; Matsugi, S.; Tanaka, T.; Fujita, M.; Tano, T.
Purification and some properties of glutathione reductase from iron-oxidizing bacterium Thiobacillus ferrooxidans
Biosci. Biotechnol. Biochem.
59
1568-1570
1995
Acidithiobacillus ferrooxidans, Acidithiobacillus ferrooxidans AP19-3
-
Danielson, U.H.; Jiang, F.; Hansson, L.O.; Mannervik, B.
Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the Cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site
Biochemistry
38
9254-9263
1999
Anabaena sp.
De Lamotte, F.; Vianey-Liaud, N.; Duviau, M.P.; Kobrehel, K.
Glutathione reductase in wheat grain. 1. Isolation and characterization
J. Agric. Food Chem.
48
4978-4983
2000
Triticum turgidum subsp. durum
Lascano, H.R.; Casano, L.M.; Melchiorre, M.N.; Trippi, V.S.
Biochemical and molecular characterisation of wheat chloroplastic glutathione reductase
Biol. Plant.
44
509-516
2001
Triticum aestivum
-
Krauth-Siegel, R.L.; Jockers-Scheruebl, M.C.; Becker, K.; Schirmer, R.H.
NADPH-dependent disulphide reductases
Biochem. Soc. Trans.
17
315-317
1989
Homo sapiens
Stoll, V.S.; Simpson, S.J.; Krauth-Siegel, R.L.; Walsh, C.T.; Pai, E.F.
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity
Biochemistry
36
6437-6447
1997
Homo sapiens (P00390), Homo sapiens
Montrichard, F.; Le Guen, F.; Laval-Martin, D.L.; Davioud-Charvet, E.
Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z
FEBS Lett.
442
29-33
1999
Euglena gracilis, Euglena gracilis Z
Gallwitz, H.; Bonse, S.; Martinez-Cruz, A.; Schlichting, I.; Schumacher, K.; Krauth-Siegel, R.L.
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies
J. Med. Chem.
42
364-372
1999
Homo sapiens
Carlberg, I.C.; Sahlman, L.; Mannervik, B.
The effect of 2,4,6-trinitrobenzenesulfonate on mercuric reductase, glutathione reductase and lipoamide dehydrogenase
FEBS Lett.
180
102-106
1985
Homo sapiens
Tsai, Y.C.; Hong, C.Y.; Liu, L.F.; Kao, C.H.
Expression of ascorbate peroxidase and glutathione reductase in roots of rice seedlings in response to NaCl and H2O2
J. Plant Physiol.
162
291-299
2005
Oryza sativa (P48642), Oryza sativa
Erat, M.; Demir, H.; Sakiroglu, H.
Purification of glutathione reductase from chicken liver and investigation of kinetic properties
Appl. Biochem. Biotechnol.
125
127-138
2005
Gallus gallus
Landino, L.M.; Moynihan, K.L.; Todd, J.V.; Kennett, K.L.
Modulation of the redox state of tubulin by the glutathione/glutaredoxin reductase system
Biochem. Biophys. Res. Commun.
314
555-560
2004
Saccharomyces cerevisiae
Bjoerkhem-Bergman, L.; Jonsson, K.; Eriksson, L.C.; Olsson, J.M.; Lehmann, S.; Paul, C.; Bjornstedt, M.
Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase
Biochem. Pharmacol.
63
1875-1884
2002
Homo sapiens
Williams, A.C.; Ford, W.C.
Functional significance of the pentose phosphate pathway and glutathione reductase in the antioxidant defenses of human sperm
Biol. Reprod.
71
1309-1316
2004
Homo sapiens
Knapp, K.G.; Swartz, J.R.
Cell-free production of active E. coli thioredoxin reductase and glutathione reductase
FEBS Lett.
559
66-70
2004
Escherichia coli
Fujii, T.; Endo, T.; Fujii, J.; Taniguchi, N.
Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys
Free Radic. Res.
36
1041-1049
2002
Rattus norvegicus
Savvides, S.N.; Scheiwein, M.; Bohme, C.C.; Arteel, G.E.; Karplus, P.A.; Becker, K.; Schirmer, R.H.
Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite
J. Biol. Chem.
277
2779-2784
2002
Plasmodium falciparum, Homo sapiens (P00390), Homo sapiens
Su, D.; Novoselov, S.V.; Sun, Q.A.; Moustafa, M.E.; Zhou, Y.; Oko, R.; Hatfield, D.L.; Gladyshev, V.N.
Mammalian selenoprotein thioredoxin/glutathione reductase: roles in disulfide bond formation and sperm maturation
J. Biol. Chem.
280
26491-26498
2005
Mus musculus, Rattus norvegicus
Erat, M.; Sakiroglu, H.; Ciftci, M.
Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo
J. Enzyme Inhib. Med. Chem.
20
69-74
2005
Homo sapiens, Rattus norvegicus
Minami, Y.; Kohama, T.; Sekimoto, Y.J.; Akasaka, K.; Matsubara, H.
Isolation and characterization of glutathione reductase from Physarum polycephalum and stage-specific expression of the enzyme in life-cycle stages with different oxidation-reduction levels
J. Eukaryot. Microbiol.
50
317-323
2003
Physarum polycephalum (Q9NL96), Physarum polycephalum
Sarma, G.N.; Savvides, S.N.; Becker, K.; Schirmer, M.; Schirmer, R.H.; Karplus, P.A.
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development
J. Mol. Biol.
328
893-907
2003
Homo sapiens (P00390), Homo sapiens, Plasmodium falciparum
Dringen, R.; Gutterer, J.M.
Glutathione reductase from bovine brain
Methods Enzymol.
348
281-288
2002
Bos taurus, Oryctolagus cuniculus, Equus caballus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus
Rendon, J.L.; del Arenal, I.P.; Guevara-Flores, A.; Uribe, A.; Plancarte, A.; Mendoza-Hernandez, G.
Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci)
Mol. Biochem. Parasitol.
133
61-69
2004
Taenia crassiceps
Chew, O.; Rudhe, C.; Glaser, E.; Whelan, J.
Characterization of the targeting signal of dual-targeted pea glutathione reductase
Plant Mol. Biol.
53
341-356
2003
Pisum sativum
Erat, M.; Sakiroglu, H.; Ciftci, M.
Purification and characterization of glutathione reductase from bovine erythrocytes
Prep. Biochem. Biotechnol.
33
283-300
2003
Bos taurus
Nagaoka, Y.; Iuchi, Y.; Ikeda, Y.; Fujii, J.
Glutathione reductase is expressed at high levels in pancreatic islet cells
Redox Rep.
9
321-324
2004
Rattus norvegicus
Henderson, G.B.; Murgolo, N.J.; Kuriyan, J.; Osapay, K.; Kominos, D.; Berry, A.; Scrutton, N.S.; Hinchliffe, N.W.; Perham, R.N.; Cerami, A.
Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction
Proc. Natl. Acad. Sci. USA
88
8769-8773
1991
Escherichia coli, Homo sapiens
Contour-Ansel, D.; Torres-Franklin, M.L.; Cruz DE Carvalho, M.H.; DArcy-Lameta, A.; Zuily-Fodil, Y.
Glutathione reductase in leaves of cowpea: cloning of two cDNAs, expression and enzymatic activity under progressive drought stress, desiccation and abscisic acid treatment
Ann. Bot.
98
1279-1287
2006
Vigna unguiculata
Loprasert, S.; Whangsuk, W.; Sallabhan, R.; Mongkolsuk, S.
The unique glutathione reductase from Xanthomonas campestris: gene expression and enzyme characterization
Biochem. Biophys. Res. Commun.
331
1324-1330
2005
Xanthomonas campestris (Q56S00), Xanthomonas campestris
Rice, K.P.; Penketh, P.G.; Shyam, K.; Sartorelli, A.C.
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU
Biochem. Pharmacol.
69
1463-1472
2005
Homo sapiens, Mus musculus
Pivetta, L.A.; Dafre, A.L.; Zeni, G.; Rocha, J.B.; Farina, M.
Acetaldehyde does not inhibit glutathione peroxidase and glutathione reductase from mouse liver in vitro
Chem. Biol. Interact.
159
196-204
2006
Mus musculus
Rachdan, D.; Lou, M.F.; Harding, J.J.
Glutathione reductase from human cataract lenses can be revived by reducing agents and by a molecular chaperone, alpha-crystallin
Curr. Eye Res.
30
919-925
2005
Homo sapiens
Erat, M.; Ciftci, M.
Effect of melatonin on enzyme activities of glutathione reductase from human erythrocytes in vitro and from rat erythrocytes in vivo
Eur. J. Pharmacol.
537
59-63
2006
Homo sapiens, Rattus norvegicus
Erat, M.; Ciftci, M.; Gumustekin, K.; Gul, M.
Effects of nicotine and vitamin E on glutathione reductase activity in some rat tissues in vivo and in vitro
Eur. J. Pharmacol.
554
92-97
2007
Rattus norvegicus
Witte, A.B.; Anestal, K.; Jerremalm, E.; Ehrsson, H.; Arner, E.S.
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
Free Radic. Biol. Med.
39
696-703
2005
Saccharomyces cerevisiae
Sahoo, R.; Dutta, T.; Das, A.; Sinha Ray, S.; Sengupta, R.; Ghosh, S.
Effect of nitrosative stress on Schizosaccharomyces pombe: inactivation of glutathione reductase by peroxynitrite
Free Radic. Biol. Med.
40
625-631
2006
Schizosaccharomyces pombe
Bauer, H.; Fritz-Wolf, K.; Winzer, A.; Kuehner, S.; Little, S.; Yardley, V.; Vezin, H.; Palfey, B.; Schirmer, R.H.; Davioud-Charvet, E.
A fluoro analogue of the menadione derivative 6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme
J. Am. Chem. Soc.
128
10784-10794
2006
Homo sapiens, Plasmodium falciparum
Deponte, M.; Urig, S.; Arscott, L.D.; Fritz-Wolf, K.; Reau, R.; Herold-Mende, C.; Koncarevic, S.; Meyer, M.; Davioud-Charvet, E.; Ballou, D.P.; Williams, C.H.; Becker, K.
Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase
J. Biol. Chem.
280
20628-20637
2005
Homo sapiens
Willmore, W.G.; Storey, K.B.
Purification and properties of glutathione reductase from liver of the anoxia-tolerant turtle, Trachemys scripta elegans
Mol. Cell. Biochem.
297
139-149
2007
Trachemys scripta
Romero-Puertas, M.C.; Corpas, F.J.; Sandalio, L.M.; Leterrier, M.; Rodriguez-Serrano, M.; Del Rio, L.A.; Palma, J.M.
Glutathione reductase from pea leaves: Response to abiotic stress and characterization of the peroxisomal isozyme
New Phytol.
170
43-52
2006
Pisum sativum
Yannarelli, G.G.; Fernandez-Alvarez, A.J.; Santa-Cruz, D.M.; Tomaro, M.L.
Glutathione reductase activity and isoforms in leaves and roots of wheat plants subjected to cadmium stress
Phytochemistry
68
505-512
2007
Triticum aestivum
Yang, M.S.; Chan, H.W.; Yu, L.C.
Glutathione peroxidase and glutathione reductase activities are partially responsible for determining the susceptibility of cells to oxidative stress
Toxicology
226
126-130
2006
Homo sapiens, Rattus norvegicus
Hu, Y.; Urig, S.; Koncarevic, S.; Wu, X.; Fischer, M.; Rahlfs, S.; Mersch-Sundermann, V.; Becker, K.
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents
Biol. Chem.
388
1069-1081
2007
Homo sapiens (P00390), Homo sapiens
Nagy, P.; Ashby, M.T.
Kinetics and mechanism of the oxidation of the glutathione dimer by hypochlorous Acid and catalytic reduction of the chloroamine product by glutathione reductase
Chem. Res. Toxicol.
20
79-87
2007
Saccharomyces cerevisiae
Tekman, B.; Ozdemir, H.; Senturk, M.; Ciftci, M.
Purification and characterization of glutathione reductase from rainbow trout (Oncorhynchus mykiss) liver and inhibition effects of metal ions on enzyme activity
Comp. Biochem. Physiol. C
148
117-121
2008
Oncorhynchus mykiss
Yan, H.; Harding, J.J.; Xing, K.; Lou, M.F.
Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase, in conjunction with alpha-crystallin or thioltransferase
Curr. Eye Res.
32
455-463
2007
Homo sapiens
Koosz, Z.; Gazdag, Z.; Miklos, I.; Benko, Z.; Belagyi, J.; Antal, J.; Meleg, B.; Pesti, M.
Effects of decreased specific glutathione reductase activity in a chromate-tolerant mutant of Schizosaccharomyces pombe
Folia Microbiol. (Praha)
53
308-314
2008
Schizosaccharomyces pombe
Bishop, G.M.; Dringen, R.; Robinson, S.R.
Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes
Free Radic. Biol. Med.
42
1222-1230
2007
Rattus norvegicus, Rattus norvegicus Wistar
Scott, D.; Toney, M.; Muzikar, M.
Harnessing the mechanism of glutathione reductase for synthesis of active site bound metallic nanoparticles and electrical connection to electrodes
J. Am. Chem. Soc.
130
865-874
2008
Escherichia coli
Tandogan, B.; Ulusu, N.N.
The inhibition kinetics of yeast glutathione reductase by some metal ions
J. Enzyme Inhib. Med. Chem.
22
489-495
2007
Saccharomyces cerevisiae
Bulbul, M.; Erat, M.
Investigation of the effects of some sulfonamide derivatives on the activities of glucose-6-phosphate dehydrogenase, 6-phospho gluconate dehydrogenase and glutathione reductase from human erythrocytes
J. Enzyme Inhib. Med. Chem.
23
418-423
2008
Homo sapiens
Prasad, C.V.; Kodliwadmath, M.V.; Kodliwadmath, G.B.
Erythrocyte glutathione peroxidase, glutathione reductase activities and blood glutathione content in leprosy
J. Infect.
56
469-473
2008
Homo sapiens
Friebolin, W.; Jannack, B.; Wenzel, N.; Furrer, J.; Oeser, T.; Sanchez, C.P.; Lanzer, M.; Yardley, V.; Becker, K.; Davioud-Charvet, E.
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum
J. Med. Chem.
51
1260-1277
2008
Plasmodium falciparum
Ulusu, N.N.; Tandogan, B.
Purification and kinetic properties of glutathione reductase from bovine liver
Mol. Cell. Biochem.
303
45-51
2007
Bos taurus
Morin, C.; Besset, T.; Moutet, J.C.; Fayolle, M.; Brueckner, M.; Limosin, D.; Becker, K.; Davioud-Charvet, E.
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase
Org. Biomol. Chem.
6
2731-2742
2008
Homo sapiens, Plasmodium falciparum
Bashir, K.; Nagasaka, S.; Itai, R.N.; Kobayashi, T.; Takahashi, M.; Nakanishi, H.; Mori, S.; Nishizawa, N.K.
Expression and enzyme activity of glutathione reductase is upregulated by Fe-deficiency in graminaceous plants
Plant Mol. Biol.
65
277-284
2007
Oryza sativa, Triticum aestivum, Zea mays, Hordeum vulgare (A8CCK2), Hordeum vulgare (A8CCK8), Hordeum vulgare
Angelucci, F.; Miele, A.E.; Boumis, G.; Dimastrogiovanni, D.; Brunori, M.; Bellelli, A.
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase
Proteins
72
936-945
2008
Schistosoma mansoni
Yu, J.; Zhou, C.
Crystal structure of glutathione reductase Glr1 from the yeast Saccharomyces cerevisiae
Proteins Struct. Funct. Bioinform.
68
972-979
2007
Saccharomyces cerevisiae (P41921), Saccharomyces cerevisiae
Gunaratnam, M.; Grant, M.H.
Cr(VI) inhibits DNA, RNA and protein syntheses in hepatocytes: involvement of glutathione reductase, reduced glutathione and DT-diaphorase
Toxicol. In Vitro
22
879-886
2008
Homo sapiens
Lalaouni, A.; Henderson, C.; Kupper, C.; Grant, M.H.
The interaction of chromium (VI) with macrophages: depletion of glutathione and inhibition of glutathione reductase
Toxicology
236
76-81
2007
Homo sapiens
Arning, J.; Dringen, R.; Schmidt, M.; Thiessen, A.; Stolte, S.; Matzke, M.; Bottin-Weber, U.; Caesar-Geertz, B.; Jastorff, B.; Ranke, J.
Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2
Toxicology
246
203-212
2008
Homo sapiens
Erat, M.; Ozturk, L.; Casano, L.M.; Demir, Y.
Effect of polyamines on glutathione reductase activity in spinach
Z. Naturforsch. C
63
260-266
2008
Spinacia oleracea
Burritt, D.J.
The polycyclic aromatic hydrocarbon phenanthrene causes oxidative stress and alters polyamine metabolism in the aquatic liverwort Riccia fluitans L
Plant Cell Environ.
31
1416-1431
2008
Riccia fluitans
Park, U.H.; Han, H.S.; Um, E.; An, X.H.; Kim, E.J.; Um, S.J.
Redox regulation of transcriptional activity of retinoic acid receptor by thioredoxin glutathione reductase (TGR)
Biochem. Biophys. Res. Commun.
390
241-246
2009
Mus musculus
Sentuerk, M.; Guelcin, I.; Ciftci, M.; Kuefrevioglu, O.I.
Dantrolene inhibits human erythrocyte glutathione reductase
Biol. Pharm. Bull.
31
2036-2039
2008
Homo sapiens
Sentuerk, M.; Talaz, O.; Ekinci, D.; Cavdar, H.; Kuefrevio?lu, O.I.
In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates
Bioorg. Med. Chem. Lett.
19
3661-3663
2009
Homo sapiens
Cardoso, L.; Ferreira, S.; Hermes-Lima, M.
Reductive inactivation of yeast glutathione reductase by Fe(II) and NADPH
Comp. Biochem. Physiol. A
151
313-321
2008
Saccharomyces cerevisiae
Tarrio, N.; Garcia-Leiro, A.; Cerdan, M.E.; Gonzalez-Siso, M.I.
The role of glutathione reductase in the interplay between oxidative stress response and turnover of cytosolic NADPH in Kluyveromyces lactis
FEMS Yeast Res.
8
597-606
2008
Kluyveromyces lactis, Kluyveromyces lactis NRRL-Y1140
Chen, C.J.; Huang, C.Y.; Huang, J.K.; Lin, C.Y.; Lin, C.T.
Cloning, expression, and purification of a functional glutathione reductase from sweet potato (Ipomoea batatas [L.] Lam): Kinetic studies and characterization
J. Agric. Food Chem.
57
4403-4408
2009
Ipomoea batatas
Senturk, M.; Kufrevioglu, O.I.; Ciftci, M.
Effects of some antibiotics on human erythrocyte glutathione reductase: an in vitro study
J. Enzyme Inhib. Med. Chem.
23
144-148
2008
Homo sapiens
Senturk, M.; Irfan Kufrevioglu, O.; Ciftci, M.
Effects of some analgesic anaesthetic drugs on human erythrocyte glutathione reductase: an in vitro study
J. Enzyme Inhib. Med. Chem.
24
420-424
2009
Homo sapiens
Sharma, M.; Khanna, S.; Bulusu, G.; Mitra, A.
Comparative modeling of thioredoxin glutathione reductase from Schistosoma mansoni: a multifunctional target for antischistosomal therapy
J. Mol. Graph. Model.
27
665-675
2009
Schistosoma mansoni (Q962Y6), Schistosoma mansoni
Iribarne, F.; Paulino, M.; Aguilera, S.; Tapia, O.
Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and Molecular Dynamics studies
J. Mol. Graph. Model.
28
371-381
2009
Homo sapiens (P00390), Homo sapiens
Hong, C.Y.; Chao, Y.Y.; Yang, M.Y.; Cho, S.C.; Huei Kao, C.
Na+ but not Cl- or osmotic stress is involved in NaCl-induced expression of glutathione reductase in roots of rice seedlings
J. Plant Physiol.
166
1598-1606
2009
Oryza sativa
Abd Ellah, M.R.; Okada, K.; Goryo, M.; Kobayashi, S.; Oishi, A.; Yasuda, J.
Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy
J. Vet. Med. Sci.
70
861-864
2008
Bos taurus
Franco, J.L.; Posser, T.; Mattos, J.J.; Sanchez-Chardi, A.; Trevisan, R.; Oliveira, C.S.; Carvalho, P.S.; Leal, R.B.; Marques, M.R.; Bainy, A.C.; Dafre, A.L.
Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: glutathione reductase as a target
Mar. Environ. Res.
66
88-89
2008
Cyprinus carpio
Rousar, T.; Parik, P.; Kucera, O.; Bartos, M.; Cervinkova, Z.
Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro
Physiol. Res.
59
225-232
2010
Saccharomyces cerevisiae, Rattus norvegicus
Hnken, M.; Harder, J.; Kirst, G.O.
Epiphytic bacteria on the Antarctic ice diatom Amphiprora kufferathii Manguin cleave hydrogen peroxide produced during algal photosynthesis
Plant Biol.
10
519-526
2008
Sulfitobacter sp., Colwellia sp., Pibocella sp., Amphiprora kufferathii, Colwellia sp. MH2, Sulfitobacter sp. MH1, Pibocella sp. MH3
Ding, S.; Lu, Q.; Zhang, Y.; Yang, Z.; Wen, X.; Zhang, L.; Lu, C.
Enhanced sensitivity to oxidative stress in transgenic tobacco plants with decreased glutathione reductase activity leads to a decrease in ascorbate pool and ascorbate redox state
Plant Mol. Biol.
69
577-592
2009
Nicotiana tabacum (P80461), Nicotiana tabacum
Kertulis-Tartar, G.M.; Rathinasabapathi, B.; Ma, L.Q.
Characterization of glutathione reductase and catalase in the fronds of two Pteris ferns upon arsenic exposure
Plant Physiol. Biochem.
47
960-965
2009
Pteris ensiformis, Pteris vittata
Marty, L.; Siala, W.; Schwarzlaender, M.; Fricker, M.D.; Wirtz, M.; Sweetlove, L.J.; Meyer, Y.; Meyer, A.J.; Reichheld, J.P.; Hell, R.
The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis
Proc. Natl. Acad. Sci. USA
106
9109-9114
2009
Arabidopsis thaliana
Tandogan, B.; Ulusu, N.N.
Purification and kinetics of bovine kidney cortex glutathione reductase
Protein Pept. Lett.
17
667-674
2010
Bos taurus
Arias, D.G.; Marquez, V.E.; Beccaria, A.J.; Guerrero, S.A.; Iglesias, A.A.
Purification and characterization of a glutathione reductase from Phaeodactylum tricornutum
Protist
161
91-101
2010
Phaeodactylum tricornutum
Zhao, Y.; Seefeldt, T.; Chen, W.; Wang, X.; Matthees, D.; Hu, Y.; Guan, X.
Effects of glutathione reductase inhibition on cellular thiol redox state and related systems
Arch. Biochem. Biophys.
485
56-62
2009
Chlorocebus aethiops
Grellier, P.; Maroziene, A.; Nivinskas, H.; Sarlauskas, J.; Aliverti, A.; Cenas, N.
Antiplasmodial activity of quinones: roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reductase
Arch. Biochem. Biophys.
494
32-39
2010
Homo sapiens, Plasmodium falciparum, Plasmodium falciparum FcB1
Li, S.; Zhang, J.; Li, J.; Chen, D.; Matteucci, M.; Curd, J.; Duan, J.X.
Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302
Biol. Trace Elem. Res.
136
294-301
2010
Mus musculus
Zhao, Y.; Seefeldt, T.; Chen, W.; Carlson, L.; Stoebner, A.; Hanson, S.; Foll, R.; Matthees, D.P.; Palakurthi, S.; Guan, X.
Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation
Free Radic. Biol. Med.
47
176-183
2009
Homo sapiens
Tandogan, B.; Ulusu, N.N.
Inhibition of purified bovine liver glutathione reductase with some metal ions
J. Enzyme Inhib. Med. Chem.
25
68-73
2010
Bos taurus
Liu, X.; Sturla, S.J.
Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues
Mol. Biosyst.
5
1013-1024
2009
Saccharomyces cerevisiae
Can, B.; Kulaksiz Erkmen, G.; Dalmizrak, O.; Ogus, I.H.; Ozer, N.
Purification and characterisation of rat kidney glutathione reductase
Protein J.
29
250-256
2010
Rattus norvegicus
Tandogan, B.; Guevenc, A.; Calis, I.; Ulusu, N.N.
In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase
Acta Biochim. Pol.
58
471-475
2011
Bos taurus
Al-Senaidy, A.
Purification and characterization of glutathione reductase from camel (Camelus dromedaries) erythrocytes
Eur. J. Sci. Res.
48
142-154
2010
Camelus dromedarius
-
Yan, J.; Ralston, M.M.; Meng, X.; Bongiovanni, K.D.; Jones, A.L.; Benndorf, R.; Nelin, L.D.; Joshua Frazier, W.; Rogers, L.K.; Smith, C.V.; Liu, Y.
Glutathione reductase is essential for host defense against bacterial infection
Free Radic. Biol. Med.
61C
320-332
2013
Mus musculus
Karaman, M.; Akkemik, E.; Budak, H.; Ciftci, M.
In vitro effects of some drugs on human erythrocyte glutathione reductase
J. Enzyme Inhib. Med. Chem.
27
18-23
2012
Homo sapiens
Ekinci, D.; Sentuerk, M.
Assesment of metal inhibition of antioxidant enzyme glutathione reductase from rainbow trout liver
J. Enzyme Inhib. Med. Chem.
28
11-15
2013
Oncorhynchus mykiss
Kedrowski, B.L.; Gutow, J.H.; Stock, G.; Smith, M.; Jordan, C.; Masterson, D.S.
Glutathione reductase activity with an oxidized methylated glutathione analog
J. Enzyme Inhib. Med. Chem.
29
491-494
2014
Saccharomyces cerevisiae
Kim, I.S.; Kim, Y.S.; Yoon, H.S.
Glutathione reductase from Oryza sativa increases acquired tolerance to abiotic stresses in a genetically modified Saccharomyces cerevisiae strain
J. Microbiol. Biotechnol.
22
1557-1567
2012
Oryza sativa (P48642), Oryza sativa
Arora, K.; Ahmad, R.; Srivastava, A.
Purification and characterization of glutathione reductase (E.C. 1.8.1.7) from bovine filarial worms Setaria cervi
J. Parasit. Dis.
37
94-104
2013
Setaria cervi
Yadav, S.S.; Srikanth, E.; Singh, N.; Rathaur, S.
Identification of GR and TrxR systems in Setaria cervi: Purification and characterization of glutathione reductase
Parasitol. Int.
62
193-198
2013
Setaria cervi
Wu, T.M.; Lin, W.R.; Kao, Y.T.; Hsu, Y.T.; Yeh, C.H.; Hong, C.Y.; Kao, C.H.
Identification and characterization of a novel chloroplast/mitochondria co-localized glutathione reductase 3 involved in salt stress response in rice
Plant Mol. Biol.
83
379-390
2013
Oryza sativa (Q7XEM9), Oryza sativa
Gill, S.S.; Anjum, N.A.; Hasanuzzaman, M.; Gill, R.; Trivedi, D.K.; Ahmad, I.; Pereira, E.; Tuteja, N.
Glutathione and glutathione reductase: a boon in disguise for plant abiotic stress defense operations
Plant Physiol. Biochem.
70
204-212
2013
Arachis hypogaea, Beta vulgaris, Cajanus cajan, Citrullus lanatus, Cucumis sativus, Cucumis melo, Glycine max, Nicotiana tabacum, no activity in Drosophila melanogaster, Oryza sativa, Vigna radiata var. radiata, Pisum sativum, Spinacia oleracea, Triticum aestivum, Zea mays, Acorus calamus, Citrus trifoliata, no activity in Trypanosoma sp.
Mhamdi, A.; Hager, J.; Chaouch, S.; Queval, G.; Han, Y.; Taconnat, L.; Saindrenan, P.; Gouia, H.; Issakidis-Bourguet, E.; Renou, J.P.; Noctor, G.
Arabidopsis GLUTATHIONE REDUCTASE1 plays a crucial role in leaf responses to intracellular hydrogen peroxide and in ensuring appropriate gene expression through both salicylic acid and jasmonic acid signaling pathways
Plant Physiol.
153
1144-1160
2010
Arabidopsis thaliana
Tandogan, B.; Ulusu, N.N.
Comparative in vitro effects of some metal ions on bovine kidney cortex glutathione reductase
Prep. Biochem. Biotechnol.
40
405-411
2010
Bos taurus
Garcia-Leiro, A.; Cerdan, M.E.; Gonzalez-Siso, M.I.
A functional analysis of Kluyveromyces lactis glutathione reductase
Yeast
27
431-441
2010
Kluyveromyces lactis, Kluyveromyces lactis NRRL-Y1140
Zhang, X.; Quan, G.; Wang, J.; Han, H.; Chen, S.; Guo, S.; Yin, H.
Functional validation of Phragmites communis glutathione reductase (PhaGR) as an essential enzyme in salt tolerance
Appl. Biochem. Biotechnol.
175
3418-3430
2015
Phragmites australis
Garnik, E.Y.; Belkov, V.I.; Tarasenko, V.I.; Korzun, M.A.; Konstantinov, Y.M.
Glutathione reductase gene expression depends on chloroplast signals in Arabidopsis thaliana
Biochemistry (Moscow)
81
364-372
2016
Arabidopsis thaliana, Arabidopsis thaliana Columbia
Ding, S.; Jiang, R.; Lu, Q.; Wen, X.; Lu, C.
Glutathione reductase 2 maintains the function of photosystem II in Arabidopsis under excess light
Biochim. Biophys. Acta
1857
665-677
2016
Arabidopsis thaliana, Arabidopsis thaliana (P42770)
Ku, M.; Baek, Y.U.; Kwak, M.K.; Kang, S.O.
Candida albicans glutathione reductase downregulates Efg1-mediated cyclic AMP/protein kinase A pathway and leads to defective hyphal growth and virulence upon decreased cellular methylglyoxal content accompanied by activating alcohol dehydrogenase and glycolytic enzymes
Biochim. Biophys. Acta
1861
772-788
2017
Candida albicans (Q59NQ5), Candida albicans
Murakami, K.; Tsubouchi, R.; Fukayama, M.; Yoshino, M.
Copper-dependent inhibition and oxidative inactivation with affinity cleavage of yeast glutathione reductase
Biometals
27
551-558
2014
Saccharomyces cerevisiae
Parrilha, G.L.; Ferraz, K.S.; Lessa, J.A.; de Oliveira, K.N.; Rodrigues, B.L.; Ramos, J.P.; Souza-Fagundes, E.M.; Ott, I.; Beraldo, H.
Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase
Eur. J. Med. Chem.
84
537-544
2014
Rattus norvegicus
Plancarte, A.; Nava, G.; Munguia, J.A.
A new thioredoxin reductase with additional glutathione reductase activity in Haemonchus contortus
Exp. Parasitol.
177
82-92
2017
Haemonchus contortus (CDJ91018), Haemonchus contortus
Ji, M.; Barnwell, C.V.; Grunden, A.M.
Characterization of recombinant glutathione reductase from the psychrophilic Antarctic bacterium Colwellia psychrerythraea
Extremophiles
19
863-874
2015
Colwellia psychrerythraea
Adem, S.; Ciftci, M.
Purification and Characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase from rat heart and inhibition effects of furosemide, digoxin, and dopamine on the enzymes aActivities
J. Biochem. Mol. Toxicol.
30
295-301
2016
Rattus norvegicus
Dawson, N.J.; Storey, K.B.
Passive regeneration of glutathione Glutathione reductase regulation from the freeze-tolerant North American wood frog, Rana sylvatica
J. Exp. Biol.
220
3162-3171
2017
Lithobates sylvaticus
Couto, N.; Malys, N.; Gaskell, S.J.; Barber, J.
Partition and turnover of glutathione reductase from Saccharomyces cerevisiae a proteomic approach
J. Proteome Res.
12
2885-2894
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Achary, V.M.; Reddy, C.S.; Pandey, P.; Islam, T.; Kaul, T.; Reddy, M.K.
Glutathione reductase a unique enzyme molecular cloning, expression and biochemical characterization from the stress adapted C4 plant, Pennisetum glaucum (L.) R. Br
Mol. Biol. Rep.
42
947-962
2015
Cenchrus americanus (A0A068EUE1), Cenchrus americanus
Rodionova, M.V.; Zharmukhamedov, S.K.; Karacan, M.S.; Venedik, K.B.; Shitov, A.V.; Tunc, T.; Mama?, S.; Kreslavski, V.D.; Karacan, N.; Klimov, V.V.; Allakhverdiev, S.I.
Evaluation of new Cu(II) complexes as a novel class of inhibitors against plant carbonic anhydrase, glutathione reductase, and photosynthetic activity in photosystem II
Photosynth. Res.
133
139-153
2017
Spinacia oleracea (Q43154), Spinacia oleracea
Yu, X.; Pasternak, T.; Eiblmeier, M.; Ditengou, F.; Kochersperger, P.; Sun, J.; Wang, H.; Rennenberg, H.; Teale, W.; Paponov, I.; Zhou, W.; Li, C.; Li, X.; Palme, K.
Plastid-localized glutathione reductase2-regulated glutathione redox status is essential for Arabidopsis root apical meristem maintenance
Plant Cell
25
4451-4468
2013
Arabidopsis thaliana (P42770), Arabidopsis thaliana
Deng, Z.; Zhao, M.; Liu, H.; Wang, Y.; Li, D.
Molecular cloning, expression profiles and characterization of a glutathione reductase in Hevea brasiliensis
Plant Physiol. Biochem.
96
53-63
2015
Hevea brasiliensis (D5LPR3), Hevea brasiliensis
Lueersen, K.; Stegehake, D.; Daniel, J.; Drescher, M.; Ajonina, I.; Ajonina, C.; Hertel, P.; Woltersdorf, C.; Liebau, E.
The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans
PLoS ONE
8
e60731
2013
Caenorhabditis elegans (Q93379), Caenorhabditis elegans
Gonul Baltaci, N.; Guler, C.; Ceylan, H.; Kalin, S.N.; Adem, S.; Kocpinar, E.F.; Erdogan, O.; Budak, H.
In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen
J. Biochem. Mol. Toxicol.
2018
e22229
2018
Rattus norvegicus (F1LRE1)
Horn, T.; Bettray, W.; Slusarenko, A.; Gruhlke, M.
S-Allylmercaptoglutathione is a substrate for glutathione reductase (E.C. 1.8.1.7) from yeast (Saccharomyces cerevisiae)
Antioxidants (Basel)
7
86
2018
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Gholampour-Faroji, N.; Farazmand, R.; Hemmat, J.; Haddad-Mashadrizeh, A.
Modeling, stability and the activity assessment of glutathione reductase from Streptococcus thermophilus insights from the in-silico simulation study
Comput. Biol. Chem.
83
107121
2019
Streptococcus thermophilus (Q60151), Streptococcus thermophilus
Harasgama, J.C.; Kasthuriarachchi, T.D.W.; Kwon, H.; Wan, Q.; Lee, J.
Molecular and functional characterization of a mitochondrial glutathione reductase homolog from redlip mullet (Liza haematocheila) Disclosing its antioxidant properties in the fish immune response mechanism
Dev. Comp. Immunol.
113
103785
2020
Planiliza haematocheilus
VuThi, H.; Jang, S.H.; Lee, C.
Cloning and characterization of a thermostable glutathione reductase from a psychrophilic Arctic bacterium Sphingomonas sp.
FEMS Microbiol. Lett.
366
fnz218
2019
Sphingomonas sp. (WP_010214957)
Venancio-Brochi, J.C.; Pereira, L.M.; Calil, F.A.; Teixeira, O.; Baroni, L.; Abreu-Filho, P.G.; Braga, G.U.L.; Nonato, M.C.; Yatsuda, A.P.
Glutathione reductase A cytoplasmic antioxidant enzyme and a potential target for phenothiazinium dyes in Neospora caninum
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Neospora caninum (F0VQD6), Neospora caninum, Neospora caninum Liverpool (F0VQD6)
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A new cold-adapted and salt-tolerant glutathione reductase from antarctic psychrophilic bacterium Psychrobacter sp. and its resistance to oxidation
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Psychrobacter sp. ANT206
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Mechanistic and structural insights into the in vitro inhibitory action of hypericin on glutathione reductase purified from bakers yeast
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Saccharomyces cerevisiae (P41921), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P41921)
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Mus musculus (P47791)
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Identification and biochemical characterization of the glutathione reductase family from Populus trichocarpa
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Populus trichocarpa (A0A2K1XHK8), Populus trichocarpa (A0A2K2BSL2), Populus trichocarpa (A9PHY8), Populus trichocarpa
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