1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.7 glutathione-disulfide reductase

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Results	in table
43	Activating Compound
13813	AA Sequence
7	Application
1	CAS Registry Number
31	Cloned(Commentary)
378	Cofactor
19	Crystallization (Commentary)
2453	Disease/ Diagnostics
25	Expression
51	General Information
69	General Stability
117	IC50 Value
526	Inhibitors
28	kcat/KM [mM/s]
149	Ki Value [mM]
241	KM Value [mM]
112	Localization
27	Metals/Ions
136	Molecular Weight [Da]
131	Natural Substrates/ Products (Substrates)
559	Organism
1	Oxidation Stability
5	Pathway
38	PDB ID
88	pH Optimum
21	pH Range
22	pH Stability
7	pI Value
4	Posttranslational Modification
15	Protein Variants
103	Purification (Commentary)
39	Reaction
4	Reaction Type
284	Reference
1	Renatured (Commentary)
216	Source Tissue
120	Specific Activity [micromol/min/mg]
48	Storage Stability
440	Substrates and Products (Substrate)
119	Subunits
271	Synonyms
1	Systematic Name
62	Temperature Optimum [°C]
7	Temperature Range [°C]
47	Temperature Stability [°C]
71	Turnover Number [1/s]

pH Stability

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pH Stability on EC 1.8.1.7 - glutathione-disulfide reductase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3

Saccharomyces cerevisiae

-

stable

394709

4

Ipomoea batatas

-

glutathione reductase has little or no activity at pH 4.0 or lower

698440

4 - 10

Cyberlindnera mrakii

-

-

394770

4.5

Psychrobacter sp. ANT206

-

30 min, about 60% loss of activity

764906

5

Psychrobacter sp. ANT206

-

30 min, about 50% loss of activity

764906

5.5

Psychrobacter sp. ANT206

-

30 min, about 40% loss of activity

764906

5.6

Spinacia oleracea

-

30 min, stable

394745

5.8 - 8.4

Euglena gracilis

-

67°C: stable, 78°C: unstable

394720

6

Psychrobacter sp. ANT206

-

30 min, about 35% loss of activity

764906

6 - 8

Acidithiobacillus thiooxidans

-

unstable below and above

394748

6.5

Psychrobacter sp. ANT206

-

30 min, about 30% loss of activity

764906

6.5 - 10

Phaeodactylum tricornutum

-

the enzyme remains stable in 100 mM Tris-HCl buffer between pH 6.5 and 10.0, the activity remains practically unchanged between pH 6.5-7.5 and decreases significantly only above pH 8.5

701146

7

Psychrobacter sp. ANT206

-

30 min, about 15% loss of activity

764906

7.3

Bos taurus

-

optimally stable at

660339

7.4

Gallus gallus

-

optimally stable at

657570

7.5

3 entries

7.5 - 9.5

Escherichia coli

-

4°C, stable

394737

8

2 entries

8.5

Psychrobacter sp. ANT206

-

30 min, about 30% loss of activity

764906

7.5

Escherichia coli

-

unstable below

394737

7.5

Psychrobacter sp. ANT206

-

30 min, about less than 5% loss of activity

764906

7.5

Rattus norvegicus

-

stable for 3 days

742814

8

Oncorhynchus mykiss

-

7 days in 50 mM Tris–HCl buffer, 76.25% of initial activity

686233

8

Psychrobacter sp. ANT206

-

30 min, about 15% loss of activity

764906