1.14.19.3: acyl-CoA 6-desaturase

This is an abbreviated version!
For detailed information about acyl-CoA 6-desaturase, go to the full flat file.

Word Map on EC 1.14.19.3

Reaction

alpha-linolenoyl-CoA
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
stearidonoyl-CoA
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

acyl-CoA DELTA6-desaturase, acyl-CoA desaturase, acyl-CoA-dependent DELTA6-desaturase, AsD6DES, D6 desaturase, d6-des, D6D, D6Des, DEALTA6I, delta 6 desaturase, DELTA 6-desaturase, delta 6-fatty acid desaturase, DELTA-6 desaturase, delta-6 fatty acid desaturase, DELTA-6-desaturase, DELTA6 desaturase, DELTA6 fatty acid desaturase, DELTA6 fatty acyl desaturases, DELTA6-acyl CoA desaturase, DELTA6-acyl-group desaturase, DELTA6-desaturase, DELTA6-desaturase II, DELTA6-fatty acid desaturase, DELTA6-fatty acyl-CoA desaturase, delta61, DELTA6fad_b, DES6, desaturase, fatty acid DA6-, desaturase, linoleate, DesI, EaD6DES, EC 1.14.99.25, FA desaturase 2, FADS2, FADS6, fadsd6, FAT-3, fatty acid 6-desaturase, fatty acid DA6-desaturase, fatty acid DELTA 6-desaturase, fatty acid delta-6 desaturase, fatty acid DELTA6-desaturase, fatty acid desaturase 2, fatty acid desaturase-2, GcFADS2, linoleate desaturase, linoleic acid desaturase, linoleic desaturase, linoleoyl CoA desaturase, linoleoyl-coenzyme A desaturase, long-chain fatty acid DELTA6-desaturase, MaFADS6, MaFADS6-I, Md6, MpFADS6, PiDesD6, TpFADS2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.3 acyl-CoA 6-desaturase

Substrates Products

Substrates Products on EC 1.14.19.3 - acyl-CoA 6-desaturase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid + AH2 + O2
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoic acid + A + H2O
show the reaction diagram
-
-
-
-
?
24-carbon fatty acid + AH2 + O2
? + A + H2O
show the reaction diagram
alpha-linolenic acid + AH2 + O2
(6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraenoic acid + A + H2O
show the reaction diagram
preferred substrate
-
-
?
alpha-linolenic acid + AH2 + O2
?
show the reaction diagram
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + H2O
show the reaction diagram
alpha-linolenic acid + AH2 + O2
octadeca-6,9,12,15-tetraenoic acid + A + H2O
show the reaction diagram
-
-
-
?
alpha-linolenic acid + AH2 + O2
octadecatetraenoic acid + A + H2O
show the reaction diagram
-
-
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + H2O
show the reaction diagram
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
alpha-linoleoyl-CoA + AH2 + O2
stearidonoyl-CoA + A + 2 H2O
show the reaction diagram
gamma-linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
show the reaction diagram
-
39% conversion efficiency
-
-
?
gamma-linolenic acid + AH2 + O2
cis-6,9,12,15-octadecatetraenoic acid + A + H2O
show the reaction diagram
-
-
-
-
?
gamma-linolenic acid methyl ester + O2
?
show the reaction diagram
heptadec-9-enoic acid + AH2 + O2
heptadec-6,9-dienoic acid + A + H2O
show the reaction diagram
-
conversion rate is 17%
-
-
?
linoleic acid + AH2 + O2
?
show the reaction diagram
linoleic acid + AH2 + O2
gamma-linoleic acid + A + H2O
show the reaction diagram
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
show the reaction diagram
linolenic acid + AH2 + O2
arachidonic acid + A + H2O
show the reaction diagram
linoleoyl phosphatidylcholine + AH2 + O2
gamma-linolenoylphosphatidylcholine + A + H2O
show the reaction diagram
-
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
linoleoyl-CoA + AH2 + O2
gamma-linolenoyl-CoA + A + 2 H2O
show the reaction diagram
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
monogalactosydiacylglycerol + AH2 + O2
? + A + H2O
show the reaction diagram
octadec-9,12-dienoic acid + AH2 + O2
octadec-6,9,12-trienoic acid + A + H2O
show the reaction diagram
-
conversion rate is 11.5%
-
-
?
octadec-9-enoic acid + AH2 + O2
octadec-6,9-dienoic acid + A + H2O
show the reaction diagram
-
conversion rate is 19.1%
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
show the reaction diagram
octadecanoate + AH2 + O2
? + A + H2O
show the reaction diagram
oleic acid + AH2 + O2
?
show the reaction diagram
-
-
-
-
?
palmitate + AH2 + O2
sapienate + A + H2O
show the reaction diagram
palmitic acid + AH2 + O2
hexadec-6-enoic acid + A + H2O
show the reaction diagram
palmitoyl-[acyl-carrier protein] + reduced acceptor + O2
6-hexadecenoyl-[acyl-carrier protein] + acceptor + H2O
show the reaction diagram
-
-
-
?
stearoyl-[acyl-carrier protein] + reduced acceptor + O2
6-octadecenoyl-[acyl-carrier protein] + 9-octadecenoyl-[acyl-carrier protein]acceptor + H2O
show the reaction diagram
-
-
ratio of activity: 2/1
?
additional information
?
-