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Literature summary for 1.14.19.3 extracted from

  • Shokri, E.; Nematzadeh, G.; Zolala, J.; Nasiri, N.; Kazemi-Tabar, S.; Hosseinpour-Azad, N.
    Delta-6 desaturase makes a different fatty acid profile of seed oil in Iranian borage (Echium amoenum Fisch. and Mey.) (2014), Acta Physiol. Plant., 36, 2413-2418 .
No PubMed abstract available
Search for more literature for 1.14.19.3

Cloned(Commentary)

Cloned (Comment) Organism
gene d6-des, DNA and amino acid sequence determination and analysis, sequence comparisons Echium amoenum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Echium amoenum
-
 stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Echium amoenum
-
 gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Echium amoenum D2KP14
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
 Echium amoenum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Echium amoenum stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Echium amoenum gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Subunits

Subunits Comment Organism
More secondary structure of the enzyme deduced from its primary structure using computational simulation Echium amoenum

Synonyms

Synonyms Comment Organism
d6-des
-
 Echium amoenum
D6Des
-
 Echium amoenum
DELTA-6 desaturase
-
 Echium amoenum
EaD6DES
-
 Echium amoenum

Cofactor

Cofactor Comment Organism Structure
cytochrome b5 the enzyme contains a cytochrome b5 domain and three conserved histidine-rich motifs Echium amoenum

General Information

General Information Comment Organism
evolution weak activity and different secondary structure of delta-6 desaturase (D6DES) in Echium amoenum compared with D6DESs of other species Echium amoenum
additional information analysis of functional sites and substrate binding motifs of D6DES enzyme, overview Echium amoenum
physiological function D6DES enzyme is responsible for converting linoleic acid and alpha-linolenic acid to gamma-linolenoic acid and stearidonic acid Echium amoenum