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evolution
phylogenetic tree of AsD6DES and delta 6- and delta 5-desaturases
evolution
weak activity and different secondary structure of delta-6 desaturase (D6DES) in Echium amoenum compared with D6DESs of other species
metabolism
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the enzyme takes part in the fatty Acid synthesis pathway, detailed overview
metabolism
delta 6-desaturase involved in very-long-chain polyunsaturated fatty acid synthesis
metabolism
fatty acid delta 6-desaturase (D6DES) and elongases are key enzymes in the synthesis of polyunsaturated fatty acids (PUFAs) including arachidonic acid (ARA) and eicosapentaenoic acid (EPA) from microorganisms to higher animals. Proposed pathways of polyunsaturated fatty acid biosynthesis from a-linolenic acid and linoleic acid in Acanthopagrus schlegelii, overview
metabolism
the enzyme follows the omega3 and omega6 pathways. Regulation of surface-membrane enzymes such as delta-6-desaturase and secretory phospholipase A2 by hemp seed and evening primrose oils as well as hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients having beneficial effects in improving clinical symptoms and signs in the patients, possible mechanisms, overview
metabolism
the enzyme is involved in the aerobic very long chain-polyunsaturated fatty acid biosynthetic pathways, overview
metabolism
the enzyme is involved in the aerobic very long chain-polyunsaturated fatty acid biosynthetic pathways, overview
metabolism
the enzyme seems to be a rate-limiting enzyme of the long-chain polyunsaturated fatty acids (LC-PUFAs) biosynthesis
metabolism
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the enzyme is involved in the aerobic very long chain-polyunsaturated fatty acid biosynthetic pathways, overview
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metabolism
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delta 6-desaturase involved in very-long-chain polyunsaturated fatty acid synthesis
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metabolism
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the enzyme is involved in the aerobic very long chain-polyunsaturated fatty acid biosynthetic pathways, overview
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physiological function
fatty acid DELTA6-desaturase is the essential enzyme for polyunsaturated fatty acids biosynthesis and is responsible for the first step by converting linoleic acid to gamma-linolenoyl-CoA, and alpha-linolenic acid to stearidonic acid
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
mechanisms involved in the nutritional modulation of DELTA6D, overview
physiological function
D6DES enzyme is responsible for converting linoleic acid and alpha-linolenic acid to gamma-linolenoic acid and stearidonic acid
physiological function
delta 6 desaturase (FADS2) is a critical bifunctional enzyme required for polyunsaturated fatty acid biosynthesis, high catalytic activity of FADS2s from Glossomastix chrysoplasta. It controls the conversion of linoleoyl-CoA and alpha-linolenoyl-CoA to gamma-linolenic acid and stearidonic acid, respectively
physiological function
delta 6 desaturase (FADS2) is a critical bifunctional enzyme required for polyunsaturated fatty acid biosynthesis, high catalytic activity of FADS2s from Thalassiosira pseudonana. It controls the conversion of linoleoyl-CoA and alpha-linolenoyl-CoA to gamma-linolenic acid and stearidonic acid, respectively
physiological function
microbial species have different propensity for accumulating omega6- or omega3-series polyunsaturated fatty acids, which may be determined by the substrate preference of FADS6 enzyme, molecular mechanism of FADS6 substrate specificity, overview. Micromonas pusilla strain CCMP1545 synthesizes high levels of eicosapentaenoic acid
physiological function
microbial species have different propensity for accumulating omega6- or omega3-series polyunsaturated fatty acids, which may be determined by the substrate preference of FADS6 enzyme, molecular mechanism of FADS6 substrate specificity, overview. Mortierella alpina strain ATCC 32222 synthesizes high levels of arachidonic acid
physiological function
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neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid's (PUFA) nutritional status. At birth, preterm infants have D6D activity as high as that of term infants, D6D activity declines to about one-third at one month, then further decreases to about one-sixth at six months and remained stable until 12 months. The postnatal change in arachidonic acid exhibits a similar pattern to that of D6D activity. Docosahexaenoic acid shows a transient decrease at one month and recovers to the cord blood level at six months. Enzyme D6D may regulate PUFA profile in preterm infants, especially during the early postnatal period. Long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and docosahexaenoic acid (DHA), are critical nutrients for humans, as humans do not have the enzymes to synthesize PUFA from acetyl CoA, but are instead able to produce AA and DHA from precursor PUFAs, linoleic acid (LA), and alpha-linolenic acid (ALA), respectively
physiological function
regulation of surface-membrane enzymes such as delta-6-desaturase and secretory phospholipase A2 by hemp seed and evening primrose oils as well as hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients having beneficial effects in improving clinical symptoms and signs in the patients, possible mechanisms, overview. FADS2 enzyme catalyzes the rate-limiting step in the biosynthetic pathways for polyunsaturated fatty acids that are incorporated into cell membranes, thereby affecting permeability, and functional propertiesof cells. There isa correlation between multile sclerosis and a rapid fall of FADS6 enzyme activity
physiological function
the FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue, association between fatty acid metabolism and adipose tissue inflammation in the Kuopio obesity surgery study, altered interleukin-1beta and NF-kappaB pathway gene expressio, overview. D6D enzyme activity in serum triglyceride fraction correlates with interleukin-1beta expression in subcutaneous adipose tissue. Surgery-induced weight loss is correlated with genotype FADS2
physiological function
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microbial species have different propensity for accumulating omega6- or omega3-series polyunsaturated fatty acids, which may be determined by the substrate preference of FADS6 enzyme, molecular mechanism of FADS6 substrate specificity, overview. Mortierella alpina strain ATCC 32222 synthesizes high levels of arachidonic acid
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physiological function
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microbial species have different propensity for accumulating omega6- or omega3-series polyunsaturated fatty acids, which may be determined by the substrate preference of FADS6 enzyme, molecular mechanism of FADS6 substrate specificity, overview. Micromonas pusilla strain CCMP1545 synthesizes high levels of eicosapentaenoic acid
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additional information
comparison of seawater and freshwater fish desaturated fatty acid comtents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid comtents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
comparison of seawater and freshwater fish desaturated fatty acid contents, expression profiles and substrate specificities, overview
additional information
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fat-3 mutant phenotype, lifespan, and transgenerational effect of cis- and trans-triglyceride diets, overview
additional information
nutritional regulation, overview
additional information
nutritional regulation, overview
additional information
nutritional regulation, overview
additional information
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nutritional regulation, overview
additional information
analysis of functional sites and substrate binding motifs of D6DES enzyme, overview
additional information
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polyunsaturated fatty acid profile at birth and its postnatal change, overview
additional information
structure-function relationship, domain-swapping approach, two regions are essential to the catalytic mechanism: one that extends from the end of the fourth to the beginning of the fifth cytoplasmic transmembrane domain, and another that includes the C-terminal region that occurs after the sixth cytoplasmic transmembrane domain. Fatty acid contents of wild-type an dmutant strains, overview
additional information
structure-function relationship, domain-swapping approach, two regions are essential to the catalytic mechanism: one that extends from the end of the fourth to the beginning of the fifth cytoplasmic transmembrane domain, and another that includes the C-terminal region that occurs after the sixth cytoplasmic transmembrane domain. Fatty acid contents of wild-type and mutant strains, overview
additional information
the enzyme sequence displays the typical structure of microsomal FADS2 including two transmembrane domains and an N-terminal cytochrome b5 domain with the HPGG motif
additional information
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the enzyme sequence displays the typical structure of microsomal FADS2 including two transmembrane domains and an N-terminal cytochrome b5 domain with the HPGG motif