Reference on EC 2.3.2.27 - RING-type E3 ubiquitin transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chin, L.S.; Vavalle, J.P.; Li, L.
Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation
J. Biol. Chem.
277
35071-35079
2002
Rattus norvegicus (Q8CJB9)
Vander Kooi, C.W.; Ohi, M.D.; Rosenberg, J.A.; Oldham, M.L.; Newcomer, M.E.; Gould, K.L.; Chazin, W.J.
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases
Biochemistry
45
121-130
2006
Saccharomyces cerevisiae (P32523)
Gack, M.U.; Shin, Y.C.; Joo, C.H.; Urano, T.; Liang, C.; Sun, L.; Takeuchi, O.; Akira, S.; Chen, Z.; Inoue, S.; Jung, J.U.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Nature
446
916-920
2007
Homo sapiens (Q14258)
Yang, C.W.; Gonzalez-Lamothe, R.; Ewan, R.A.; Rowland, O.; Yoshioka, H.; Shenton, M.; Ye, H.; ODonnell, E.; Jones, J.D.; Sadanandom, A.
The E3 ubiquitin ligase activity of Arabidopsis PLANT U-BOX17 and its functional tobacco homolog ACRE276 are required for cell death and defense
Plant Cell
18
1084-1098
2006
Arabidopsis thaliana (Q9C7R6), Arabidopsis thaliana, Nicotiana tabacum (Q84QD7), Nicotiana tabacum, Solanum lycopersicum
Brophy, T.M.; Raab, M.; Daxecker, H.; Culligan, K.G.; Lehmann, I.; Chubb, A.J.; Treumann, A.; Moran, N.
RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3
Biochem. Biophys. Res. Commun.
369
1088-1093
2008
Homo sapiens (Q9P0P0), Homo sapiens
Duan, Z.; Gao, B.; Xu, W.; Xiong, S.
Identification of TRIM22 as a RING finger E3 ubiquitin ligase
Biochem. Biophys. Res. Commun.
374
502-506
2008
Homo sapiens (Q8IYM9)
Maruyama, Y.; Yamada, M.; Takahashi, K.; Yamada, M.
Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway
Biochem. Biophys. Res. Commun.
374
737-741
2008
Rattus norvegicus (Q9EPZ8)
Wiborg, J.; OShea, C.; Skriver, K.
Biochemical function of typical and variant Arabidopsis thaliana U-box E3 ubiquitin-protein ligases
Biochem. J.
413
447-457
2008
Arabidopsis thaliana (Q9LQ92)
Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
BMC Struct. Biol.
8
26
2008
Danio rerio (Q7ZTZ6)
Sugiura, T.; Yamaguchi, A.; Miyamoto, K.
A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95
Exp. Cell Res.
314
1519-1528
2008
Homo sapiens (Q68DV7)
Yamauchi, K.; Wada, K.; Tanji, K.; Tanaka, M.; Kamitani, T.
Ubiquitination of E3 ubiquitin ligase TRIM5alpha and its potential role
FEBS J.
275
1540-1555
2008
Homo sapiens (Q9C035), Homo sapiens
Ogawa, M.; Mizugishi, K.; Ishiguro, A.; Koyabu, Y.; Imai, Y.; Takahashi, R.; Mikoshiba, K.; Aruga, J.
Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase
Genes Cells
13
397-409
2008
Mus musculus (Q3U827)
Tatematsu, K.; Yoshimoto, N.; Okajima, T.; Tanizawa, K.; Kuroda, S.
Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta
J. Biol. Chem.
283
11575-11585
2008
Rattus norvegicus (Q62921)
Tatham, M.H.; Geoffroy, M.C.; Shen, L.; Plechanovova, A.; Hattersley, N.; Jaffray, E.G.; Palvimo, J.J.; Hay, R.T.
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Nat. Cell Biol.
10
538-546
2008
Homo sapiens (Q9UNE7)
Lee, J.H.; Terzaghi, W.; Gusmaroli, G.; Charron, J.B.; Yoon, H.J.; Chen, H.; He, Y.J.; Xiong, Y.; Deng, X.W.
Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases
Plant Cell
20
152-167
2008
Arabidopsis thaliana (Q8LGH4), Arabidopsis thaliana
Perez-Oliva, A.B.; Olivares, C.; Jimenez-Cervantes, C.; Garcia-Borron, J.C.
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas
J. Biol. Chem.
284
31714-31725
2009
Homo sapiens (O60921), Homo sapiens
Son, O.; Cho, S.K.; Kim, E.Y.; Kim, W.T.
Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase
Plant Cell Rep.
28
561-569
2009
Arabidopsis thaliana (O64425), Arabidopsis thaliana (P93030), Arabidopsis thaliana (Q8GUK7)
Eisele, F.; Wolf, D.H.
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1
FEBS Lett.
582
4143-4146
2008
Saccharomyces cerevisiae
Lee, D.H.; Choi, H.W.; Hwang, B.K.
The pepper E3 ubiquitin ligase RING1 gene, CaRING1, is required for cell death and the salicylic acid-dependent defense response
Plant Physiol.
156
2011-2025
2011
Capsicum annuum (G0T3B3)
Kong, Q.; Zeng, W.; Wu, J.; Hu, W.; Li, C.; Mao, B.
RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination
Biochem. Biophys. Res. Commun.
393
708-713
2010
Mus musculus (Q6PDX6)
Hassink, G.; Kikkert, M.; Van Voorden, S.; Lee, S.; Spaapen, R.; Van Laar, T.; Coleman, C.; Bartee, E.; Frh, K.; Chau, V.; Wiertz, E.
TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum
Biochem. J.
388
647-655
2005
Homo sapiens (O60337)
Kassenbrock, C.; Anderson, S.
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
J. Biol. Chem.
279
28017-28027
2004
Homo sapiens (P22681)
Atipairin, A.; Canyuk, B.; Ratanaphan, A.
Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature
J. Biol. Inorg. Chem.
16
217-226
2011
Homo sapiens
Du, Q.; Cui, W.; Zhang, C.; Yu, D.
GmRFP1 encodes a previously unknown RING-type E3 ubiquitin ligase in soybean (Glycine max)
Mol. Biol. Rep.
37
685-693
2010
Glycine max (C6EUD3), Glycine max
Jung, Y.; Liu, G.; Chen, X.
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
Mol. Cell. Biol.
30
1041-1048
2010
Homo sapiens (Q96PM5), Homo sapiens
Saha, A.; Lewis, S.; Kleiger, G.; Kuhlman, B.; Deshaies, R.J.
Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate
Mol. Cell
42
75-83
2011
Homo sapiens
Riley, B.E.; Lougheed, J.C.; Callaway, K.; Velasquez, M.; Brecht, E.; Nguyen, L.; Shaler, T.; Walker, D.; Yang, Y.; Regnstrom, K.; Diep, L.; Zhang, Z.; Chiou, S.; Bova, M.; Artis, D.R.; Yao, N.; Baker, J.; Yednock, T.; Johnston, J.A.
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
Nat. Commun.
4
1982
2013
Homo sapiens (O60260)
Li, W.; Tu, D.; Brunger, A.; Ye, Y.
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
Nature
446
333-337
2007
Homo sapiens (Q9UKV5)
Spratt, D.E.;, Mercier, P.; Shaw, G.S.
Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase
PLoS One
15
e74047
2013
Homo sapiens (Q9Y4X5), Homo sapiens
Han, Y.; Li, R.; Gao, J.; Miao, S.; Wang, L.
Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation
Biochem. Biophys. Res. Commun.
429
6-11
2012
Homo sapiens (Q86WT6), Homo sapiens
Huang, F.; Xiao, H.; Sun, B.L.; Yang, R.G.
Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization
Biochem. Biophys. Res. Commun.
432
208-213
2013
Arabidopsis thaliana (Q8GYT9), Homo sapiens (Q9BVG3)
Raheja, R.; Liu, Y.; Hukkelhoven, E.; Yeh, N.; Koff, A.
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity
Biochem. J.
458
537-545
2014
Mus musculus
Nguyen, L.; Plafker, K.S.; Starnes, A.; Cook, M.; Klevit, R.E.; Plafker, S.M.
The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin
Biochemistry
53
4004-4014
2014
Homo sapiens (Q96BH1)
Wang, P.; Wu, Y.; Li, Y.; Zheng, J.; Tang, J.
A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1
Cell. Signal.
25
2320-2333
2013
Homo sapiens (Q9NXI6), Homo sapiens
Buchwald, G.; van der Stoop, P.; Weichenrieder, O.; Perrakis, A.; van Lohuizen, M.; Sixma, T.K.
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b
EMBO J.
25
2465-2474
2006
Homo sapiens (Q99496)
Lee, S.J.; Choi, J.Y.; Sung, Y.M.; Park, H.; Rhim, H.; Kang, S.
E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme
FEBS Lett.
503
61-64
2001
Homo sapiens (Q99496), Homo sapiens
Dodd, R.; Allen, M.; Brown, S.; Sanderson, C.; Duncan, L.; Lehner, P.; Bycroft, M.; Read, R.
Solution structure of the Kaposis sarcoma-associated herpesvirus K3 N-terminal domain reveals a novel E2-binding C4HC3-type RING domain
J. Biol. Chem.
279
53840-53847
2004
Human gammaherpesvirus 8 (P90495), Human gammaherpesvirus 8 GK18 (P90495)
Iyengar, P.V.; Hirota, T.; Hirose, S.; Nakamura, N.
Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella
J. Biol. Chem.
286
39082-39090
2011
Rattus norvegicus (G3XDV3)
Liu, H.; Stone, S.L.
Cytoplasmic degradation of the Arabidopsis transcription factor abscisic acid insensitive 5 is mediated by the RING-type E3 ligase KEEP ON GOING
J. Biol. Chem.
288
20267-20279
2013
Arabidopsis thaliana (Q9FY48), Arabidopsis thaliana
Wang, Y.; Kim, S.M.; Trnka, M.J.; Liu, Y.; Burlingame, A.L.; Correia, M.A.
Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes
J. Biol. Chem.
290
3308-3332
2015
Homo sapiens (Q9UKV5)
Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently
J. Cell Sci.
127
3488-3504
2014
Homo sapiens (O60260)
Lim, S.D.; Cho, H.Y.; Park, Y.C.; Ham, D.J.; Lee, J.K.; Jang, C.S.
The rice RING finger E3 ligase, OsHCI1, drives nuclear export of multiple substrate proteins and its heterogeneous overexpression enhances acquired thermotolerance
J. Exp. Bot.
64
2899-2914
2013
Oryza sativa (Q337S3), Oryza sativa
Fraser, J.; Worrall, E.; Lin, Y.; Landre, V.; Pettersson, S.; Blackburn, E.; Walkinshaw, M.; Muller, P.; Vojtesek, B.; Ball, K.; Hupp, T.
Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis
J. Mol. Biol.
427
1728-1747
2014
Homo sapiens (P51668)
-
Taherbhoy, A.; Huang, O.; Cochran, A.
BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase
Nat. Commun.
6
7621
2015
Homo sapiens (Q99496)
Plechanovova, A.; Jaffray, E.G.; Tatham, M.H.; Naismith, J.H.; Hay, R.T.
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
Nature
489
115-120
2012
Rattus norvegicus (O88846)
Gao, W.; Liu, W.; Zhao, M.; Li, W.X.
NERF encodes a RING E3 ligase important for drought resistance and enhances the expression of its antisense gene NFYA5 in Arabidopsis
Nucleic Acids Res.
43
607-617
2015
Arabidopsis thaliana (Q9SYH3)
Peng, Y.J.; Shih, C.F.; Yang, J.Y.; Tan, C.M.; Hsu, W.H.; Huang, Y.P.; Liao, P.C.; Yang, C.H.
A RING-type E3 ligase controls anther dehiscence by activating the jasmonate biosynthetic pathway gene DEFECTIVE IN ANTHER DEHISCENCE1 in Arabidopsis
Plant J.
74
310-327
2013
Arabidopsis thaliana
Tian, M.; Lou, L.; Liu, L.; Yu, F.; Zhao, Q.; Zhang, H.; Wu, Y.; Tang, S.; Xia, R.; Zhu, B.; Serino, G.; Xie, Q.
The RING finger E3 ligase STRF1 is involved in membrane trafficking and modulates salt-stress response in Arabidopsis thaliana
Plant J.
82
81-92
2015
Arabidopsis thaliana (Q9LUZ9), Arabidopsis thaliana
Lim, S.D.; Hwang, J.G.; Han, A.R.; Park, Y.C.; Lee, C.; Ok, Y.S.; Jang, C.S.
Positive regulation of rice RING E3 ligase OsHIR1 in arsenic and cadmium uptakes
Plant Mol. Biol.
85
365-379
2014
Oryza sativa (Q01I44), Oryza sativa
Prasad, M.E.; Schofield, A.; Lyzenga, W.; Liu, H.; Stone, S.L.
Arabidopsis RING E3 ligase XBAT32 regulates lateral root production through its role in ethylene biosynthesis
Plant Physiol.
153
1587-1596
2010
Arabidopsis thaliana (Q6NLQ8)
Ryu, M.Y.; Cho, S.K.; Kim, W.T.
The Arabidopsis C3H2C3-type RING E3 ubiquitin ligase AtAIRP1 is a positive regulator of an abscisic acid-dependent response to drought stress
Plant Physiol.
154
1983-1997
2010
Arabidopsis thaliana (Q93ZF6)
Li, H.; Jiang, H.; Bu, Q.; Zhao, Q.; Sun, J.; Xie, Q.; Li, C.
The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic acid signaling and drought response
Plant Physiol.
156
550-563
2011
Arabidopsis thaliana (Q9ZU51)
Cho, S.K.; Ryu, M.Y.; Seo, D.H.; Kang, B.G.; Kim, W.T.
The Arabidopsis RING E3 ubiquitin ligase AtAIRP2 plays combinatory roles with AtAIRP1 in abscisic acid-mediated drought stress responses
Plant Physiol.
157
2240-2257
2011
Arabidopsis thaliana
Cheng, M.C.; Hsieh, E.J.; Chen, J.H.; Chen, H.Y.; Lin, T.P.
Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response
Plant Physiol.
158
363-375
2012
Arabidopsis thaliana (Q9LY87)
Kim, J.H.; Kim, W.T.
The Arabidopsis RING E3 ubiquitin ligase AtAIRP3/LOG2 participates in positive regulation of high-salt and drought stress responses
Plant Physiol.
162
1733-1749
2013
Arabidopsis thaliana (Q9S752)
Pauwels, L.; Ritter, A.; Goossens, J.; Nagels Durand, A.; Liu, H.X.; Gu, Y.; Geerinck, J.; Boter, M.; Vanden Bossche, R.; De Clercq, R.; Van Leene, J.; Gevaert, K.; De Jaeger, G.; Solano, R.; Stone, S.L.; Innes, R.W.; Callis, J.; Goossens, A.
The RING E3 ligase KEEP ON GOING modulates JAZ12 stability
Plant Physiol.
169
1405-1417
2015
Arabidopsis thaliana (Q9FY48)
Park, Y.C.; Kim, J.J.; Kim, D.S.; Jang, C.S.
Rice RING E3 ligase may negatively regulate gamma-ray response to mediate the degradation of photosynthesis-related proteins
Planta
241
1119-1129
2015
Oryza sativa
Ho, Y.K.; Zhi, H.; Bowlin, T.; Dorjbal, B.; Philip, S.; Zahoor, M.A.; Shih, H.M.; Semmes, O.J.; Schaefer, B.; Glover, J.N.; Giam, C.Z.
HTLV-1 tax stimulates ubiquitin E3 ligase, ring finger protein 8, to assemble lysine 63-linked polyubiquitin chains for TAK1 and IKK activation
PLoS Pathog.
11
e1005102
2015
Homo sapiens
Cohen, I.; Wiener, R.; Reiss, Y.; Ravid, T.
Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases
Proc. Natl. Acad. Sci. USA
112
E625-E632
2015
Saccharomyces cerevisiae (P40318), Saccharomyces cerevisiae (Q08109)
Suh, J.Y.; Kim, W.T.
Arabidopsis RING E3 ubiquitin ligase AtATL80 is negatively involved inphosphate mobilization and cold stress response in sufficient phosphate growth conditions
Biochem. Biophys. Res. Commun.
463
793-799
2015
Arabidopsis thaliana (Q9LM69)
Ramadan, A.; Nemoto, K.; Seki, M.; Shinozaki, K.; Takeda, H.; Takahashi, H.; Sawasaki, T.
Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes
BMC Plant Biol.
15
275
2015
Arabidopsis thaliana
Ham, S.J.; Lee, S.Y.; Song, S.; Chung, J.R.; Choi, S.; Chung, J.
Interaction between RING1 (R1) and the ubiquitin-like (UBL) domains is critical for the regulation of parkin activity
J. Biol. Chem.
291
1803-1816
2016
Homo sapiens
Hodge, C.D.; Ismail, I.H.; Edwards, R.A.; Hura, G.L.; Xiao, A.T.; Tainer, J.A.; Hendzel, M.J.; Glover, J.N.
RNF8 E3 ubiquitin ligase stimulates Ubc13 E2 conjugating activity that is essential for DNA double-strand break signaling and BRCA1 tumor suppressor recruitment
J. Biol. Chem.
291
9396-9410
2016
Homo sapiens (O76064)
Yang, L.; Liu, Q.; Liu, Z.; Yang, H.; Wang, J.; Li, X.; Yang, Y.
Arabidopsis C3HC4-RING finger E3 ubiquitin ligase AtAIRP4 positively regulates stress-responsive abscisic acid signaling
J. Integr. Plant Biol.
58
67-80
2016
Arabidopsis thaliana
Liu, L.; Jin, L.; Huang, X.; Geng, Y.; Li, F.; Qin, Q.; Wang, R.; Ji, S.; Zhao, S.; Xie, Q.; Wei, C.; Xie, C.; Ding, B.; Li, Y.
OsRFPH2-10, a RING-H2 finger E3 ubiquitin ligase, is involved in rice antiviral defense in the early stages of rice dwarf virus infection
Mol. Plant
7
1057-1060
2014
Oryza sativa
-
Yu, Y.; Xu, W.; Wang, J.; Wang, L.; Yao, W.; Yang, Y.; Xu, Y.; Ma, F.; Du, Y.; Wang, Y.
The Chinese wild grapevine (Vitis pseudoreticulata) E3 ubiquitin ligase Erysiphe necator-induced RING finger protein 1 (EIRP1) activates plant defense responses by inducing proteolysis of the VpWRKY11 transcription factor
New Phytol.
200
834-846
2013
Vitis pseudoreticulata
Shin, L.J.; Lo, J.C.; Chen, G.H.; Callis, J.; Fu, H.; Yeh, K.C.
IRT1 degradation factor1, a RING E3 ubiquitin ligase, regulates the degradation of iron-regulated transporter1 in Arabidopsis
Plant Cell
25
3039-3051
2013
Arabidopsis thaliana
Xu, D.; Lin, F.; Jiang, Y.; Huang, X.; Li, J.; Ling, J.; Hettiarachchi, C.; Tellgren-Roth, C.; Holm, M.; Deng, X.W.
The RING-finger E3 ubiquitin ligase COP1 SUPPRESSOR1 negatively regulates COP1 abundance in maintaining COP1 homeostasis in dark-grown Arabidopsis Sseedlings
Plant Cell
26
1981-1991
2014
Arabidopsis thaliana
Zhang, H.; Cui, F.; Wu, Y.; Lou, L.; Liu, L.; Tian, M.; Ning, Y.; Shu, K.; Tang, S.; Xie, Q.
The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING PROTEIN1 for degradation to modulate the salt stress response and ABA signaling in Arabidopsis
Plant Cell
27
214-227
2015
Arabidopsis thaliana
Liu, J.; Zhang, C.; Wei, C.; Liu, X.; Wang, M.; Yu, F.; Xie, Q.; Tu, J.
The RING finger ubiquitin E3 ligase OsHTAS enhances heat tolerance by promoting H2O2-induced stomatal closure in rice
Plant Physiol.
170
429-443
2016
Oryza sativa
Jang, K.; Lee, H.G.; Jung, S.J.; Paek, N.C.; Seo, P.J.
The E3 ubiquitin ligase COP1 regulates thermosensory flowering by triggering GI degradation in Arabidopsis
Sci. Rep.
5
12071
2015
Arabidopsis thaliana
Duda, D.M.; Olszewski, J.L.; Schuermann, J.P.; Kurinov, I.; Miller, D.J.; Nourse, A.; Alpi, A.F.; Schulman, B.A.
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism
Structure
21
1030-1041
2013
Homo sapiens (Q9Y4X5), Homo sapiens
Jiang, J.; Bellani, M.; Li, L.; Wang, P.; Seidman, M.M.; Wang, Y.
Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand crosslink repair
ACS Chem. Biol.
12
1858-1866
2017
Homo sapiens (Q9NW38), Homo sapiens
Lee, S.; Lee, C.; Ryu, K.; Chi, S.
The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2 Crystallization and X-ray diffraction
Acta Crystallogr. Sect. F
76
1-7
2020
Homo sapiens (Q969V5)
Temboot, P.; Lee, R.F.S.; Menin, L.; Patiny, L.; Dyson, P.J.; Ratanaphan, A.
Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity
Biochem. Biophys. Res. Commun.
488
355-361
2017
Homo sapiens (P38398)
Behera, A.P.; Naskar, P.; Agarwal, S.; Banka, P.A.; Poddar, A.; Datta, A.B.
Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications
Biochem. J.
475
1569-1582
2018
Homo sapiens (Q8ND25)
Chasapis, C.T.
Hierarchical core decomposition of RING structure as a method to capture novel functional residues within RING-type E3 ligases a structural systems biology approach
Comput. Biol. Med.
100
86-91
2018
Homo sapiens (P38398), Homo sapiens (Q00987), Homo sapiens (Q13489)
Suisse, A.; Bekes, M.; Huang, T.T.; Treisman, J.E.
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
Fly
12
118-126
2018
Mus musculus
Joo, H.; Lim, C.; Han, S.; Lee, S.
The pepper RING finger E3 ligase, CaDIR1, regulates the drought stress response via ABA-mediated signaling
Front. Plant Sci.
8
690
2017
Capsicum annuum (A0A2Z2GVU4)
Woodfield, S.E.; Guo, R.J.; Liu, Y.; Major, A.M.; Hollingsworth, E.F.; Indiviglio, S.; Whittle, S.B.; Mo, Q.; Bean, A.J.; Ittmann, M.; Lopez-Terrada, D.; Zage, P.E.
Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B
Genes Cancer
7
13-26
2016
Homo sapiens (O95155), Homo sapiens
Foglizzo, M.; Middleton, A.; Day, C.
Structure and function of the RING domains of RNF20 and RNF40, dimeric E3 ligases that monoubiquitylate Histone H2B
J. Mol. Biol.
428
4073-4086
2016
Homo sapiens (Q5VTR2), Homo sapiens
An, J.; Liu, X.; Song, L.; You, C.; Wang, X.; Hao, Y.
Apple RING finger E3 ubiquitin ligase MdMIEL1 negatively regulates salt and oxidative stresses tolerance
J. Plant Biol.
60
137-145
2017
Malus domestica
Hwang, S.; Park, H.; Han, A.; Jang, C.
Molecular characterization of Oryza sativa arsenic-induced RING E3 ligase 1 (OsAIR1) Expression patterns, localization, functional interaction, and heterogeneous overexpression
J. Plant Physiol.
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140-148
2016
Oryza sativa Japonica Group
Baranes-Bachar, K.; Levy-Barda, A.; Oehler, J.; Reid, D.A.; Soria-Bretones, I.; Voss, T.C.; Chung, D.; Park, Y.; Liu, C.; Yoon, J.B.; Li, W.; Dellaire, G.; Misteli, T.; Huertas, P.; Rothenberg, E.; Ramadan, K.; Ziv, Y.; Shiloh, Y.
The ubiquitin E3/E4 ligase UBE4A adjusts protein ubiquitylation and accumulation at sites of DNA damage, facilitating double-strand break repair
Mol. Cell
69
866-878.e7
2018
Homo sapiens (Q14139)
Shen, Q.; Hu, T.; Bao, M.; Cao, L.; Zhang, H.; Song, F.; Xie, Q.; Zhou, X.
Tobacco RING E3 ligase NtRFP1 mediates ubiquitination and proteasomal degradation of a geminivirus-encoded betaC1
Mol. Plant
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911-925
2016
Nicotiana tabacum (R4SB05), Nicotiana tabacum
Ackermann, L.; Schell, M.; Pokrzywa, W.; Kevei, E.; Gartner, A.; Schumacher, B.; Hoppe, T.
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis
Nat. Struct. Mol. Biol.
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995-1002
2016
Caenorhabditis elegans (Q09349), Caenorhabditis elegans
Baek, K.; Krist, D.T.; Prabu, J.R.; Hill, S.; Kluegel, M.; Neumaier, L.M.; von Gronau, S.; Kleiger, G.; Schulman, B.A.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Nature
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2020
Homo sapiens (P62877)
Park, J.H.; Kang, C.H.; Nawkar, G.M.; Lee, E.S.; Paeng, S.K.; Chae, H.B.; Chi, Y.H.; Kim, W.Y.; Yun, D.J.; Lee, S.Y.
EMR, a cytosolic-abundant ring finger E3 ligase, mediates ER-associated protein degradation in Arabidopsis
New Phytol.
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2018
Arabidopsis thaliana (A0A178UZG1)
Hwang, S.G.; Chapagain, S.; Han, A.R.; Park, Y.C.; Park, H.M.; Kim, Y.H.; Jang, C.S.
Molecular characterization of rice arsenic-induced RING finger E3 ligase 2 (OsAIR2) and its heterogeneous overexpression in Arabidopsis thaliana
Physiol. Plant.
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372-384
2017
Oryza sativa Japonica Group
Qi, S.; Lin, Q.; Zhu, H.; Gao, F.; Zhang, W.; Hua, X.
The RING finger E3 Ligase SpRing is a positive regulator of salt stress signaling in salt-tolerant wild tomato species
Plant Cell Physiol.
57
528-539
2016
Solanum pimpinellifolium, Solanum pimpinellifolium PI365967
Baek, W.; Lim, C.; Luan, S.; Lee, S.
The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis
Plant J.
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2019
Arabidopsis thaliana
Chapagain, S.; Park, Y.; Kim, J.; Jang, C.
Oryza sativa salt-induced RING E3 ligase 2 (OsSIRP2) acts as a positive regulator of transketolase in plant response to salinity and osmotic stress
Planta
247
925-939
2018
Oryza sativa
Jimenez-Lopez, D.; Aguilar-Henonin, L.; Gonzalez-Prieto, J.M.; Aguilar-Hernandez, V.; Guzman, P.
CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes
PLoS ONE
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e0190969
2018
Arabidopsis thaliana (Q8L649), Homo sapiens (Q6ZNA4)
Li, C.; Wang, J.; Ji, N.; Lei, C.; Zhou, D.; Zheng, Y.; Wang, K.
PpHOS1, a RING E3 ubiquitin ligase, interacts with PpWRKY22 in the BABA-induced priming defense of peach fruit against Rhizopus stolonifer
Postharvest Biol. Technol.
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111029
2020
Prunus persica
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Ma-Lauer, Y.; Carbajo-Lozoya, J.; Hein, M.; Mueller, M.; Deng, W.; Lei, J.; Meyer, B.; Kusov, Y.; Von Brunn, B.; Bairad, D.; Huenten, S.; Drosten, C.; Hermeking, H.; Leonhardt, H.; Mann, M.; Hilgenfeld, R.; Von Brunn, A.
P53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
Proc. Natl. Acad. Sci. USA
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E5192-E5201
2016
Homo sapiens (Q96PM5)
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Stewart, M.; Duncan, E.; Coronado, E.; DaRosa, P.; Pruneda, J.; Brzovic, P.; Klevit, R.
Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms
Protein Sci.
26
475-483
2017
Homo sapiens (P38398 and Q99728), Homo sapiens
Moududee, S.A.; Jiang, Y.; Gilbert, N.; Xie, G.; Xu, Z.; Wu, J.; Gong, Q.; Tang, Y.; Shi, Y.
Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase
Protein Sci.
27
1661-1669
2018
Homo sapiens (Q5U5Q3), Homo sapiens
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