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Literature summary for 2.3.2.27 extracted from

  • Lee, J.H.; Terzaghi, W.; Gusmaroli, G.; Charron, J.B.; Yoon, H.J.; Chen, H.; He, Y.J.; Xiong, Y.; Deng, X.W.
    Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases (2008), Plant Cell, 20, 152-167.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8LGH4 isoform CUL4
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Subunits

Subunits Comment Organism
More protein PRL1, for Pleiotropic Regulatory Locus 1, a DWD protein containig a DDB1 binding WD40 motif may act as part of a CUL4-based E3 ligase. PRL1 directly interacts with adaptor protein DDB1, and prl1 and cul4cs mutants exhibit similar phenotypes, including altered responses to a variety of stimuli. Protein AKIN10, Arabidopsis SNF1 Kinase Homolog 10, is degraded more slowly in cell extracts of prl1 and cul4cs than in cell extracts of the wild type Arabidopsis thaliana
More proteins containing DWD motifs, for DDB1 binding WD40, function as substrate receptors for CUL4-based E3 ligases in plants. DDB1 functions as adaptor protein that links ligase CUL4 to substrate receptors 11 Arabidopsis DWD proteins directly interact with DDB1 and may serve as substrate receptors for the DDB1–CUL4 machinery Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
CUL4
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Arabidopsis thaliana
cullin-4
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Arabidopsis thaliana