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Literature summary for 2.3.2.27 extracted from

  • Iyengar, P.V.; Hirota, T.; Hirose, S.; Nakamura, N.
    Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella (2011), J. Biol. Chem., 286, 39082-39090.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.27

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Rattus norvegicus 5737
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flagellum
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 Rattus norvegicus
-
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microtubule upon overexpression in COS7 cell Rattus norvegicus 5874
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus G3XDV3 alternative splicing generates long RING finger protein March10a, i.e. G3XDV3, and is a short RING finger-less protein March10b
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Source Tissue

Source Tissue Comment Organism Textmining
additional information expression is absent in epididymal spermatozoa Rattus norvegicus
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spermatid March10 is specifically expressed in elongating and elongated spermatids Rattus norvegicus
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testis predominant expression Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[Ube2B]-L-cysteine + [March10a]-L-lysine
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 Rattus norvegicus [Ube2B]-L-cysteine + N6-ubiquitinyl-[March10a]-L-lysine
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 ?

Synonyms

Synonyms Comment Organism
MARCH10
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 Rattus norvegicus
microtubule-associated E3 ubiquitin ligase isoform 1
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 Rattus norvegicus
RING-CH 10
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 Rattus norvegicus
RNF190
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the RING-finger domain of March10a exhibits an E3 ubiquitin ligase activity along with the E2 ubiquitin-conjugating enzyme Ube2B. March10a undergoes proteasomal degradation by autoubiquitination in transfected COS7 cells, this activity is abolished upon microtubule disassembly Rattus norvegicus