Application | Comment | Organism |
---|---|---|
medicine | the gene encoding RNF43 is upregulated in colon adenocarcinoma as well as in colon adenoma | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
nucleus | nuclear envelope, isoform NF43 co-exoists with inner nuclear membrane protein emerin | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q68DV7 | isoform RNF43 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
ubiquitination | RNF43 is ubiquitinated in intact cells | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform RNF43 interacts with HAP95, a chromatin-associated protein interfacing the nuclear envelope. HAP95 is ubiquitinated and subjected to a proteasome-dependent degradation pathway, however, HAP95 is unlikely to serve as a substrate of RNF43 ubiquitin ligase | Homo sapiens | ? | - |
? | |
[RNF43-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [RNF43]-L-lysine | isoform RNF43 has autoubiquitylation activity. RNF43 is a RING finger-dependent E3 ligase that is selective for E2 enzymes UbcH5b and UbcH5c | Homo sapiens | [RNF43-ubiquitin-carrier protein]-L-cysteine + [RNF43]-N6-ubiquitinyl-L-lysine | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | isoform RNF43 interacts with HAP95, a chromatin-associated protein interfacing the nuclear envelope. HAP95 is ubiquitinated and subjected to a proteasome-dependent degradation pathway, however, HAP95 is unlikely to serve as a substrate of RNF43 ubiquitin ligase | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
RNF43 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the gene encoding RNF43 is upregulated in colon adenocarcinoma as well as in colon adenoma | up |