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Literature summary for 2.3.2.27 extracted from

  • Sugiura, T.; Yamaguchi, A.; Miyamoto, K.
    A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95 (2008), Exp. Cell Res., 314, 1519-1528.
    View publication on PubMed

Application

Application Comment Organism
medicine the gene encoding RNF43 is upregulated in colon adenocarcinoma as well as in colon adenoma Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
nucleus nuclear envelope, isoform NF43 co-exoists with inner nuclear membrane protein emerin Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q68DV7 isoform RNF43
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ubiquitination RNF43 is ubiquitinated in intact cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform RNF43 interacts with HAP95, a chromatin-associated protein interfacing the nuclear envelope. HAP95 is ubiquitinated and subjected to a proteasome-dependent degradation pathway, however, HAP95 is unlikely to serve as a substrate of RNF43 ubiquitin ligase Homo sapiens ?
-
?
[RNF43-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [RNF43]-L-lysine isoform RNF43 has autoubiquitylation activity. RNF43 is a RING finger-dependent E3 ligase that is selective for E2 enzymes UbcH5b and UbcH5c Homo sapiens [RNF43-ubiquitin-carrier protein]-L-cysteine + [RNF43]-N6-ubiquitinyl-L-lysine
-
?

Subunits

Subunits Comment Organism
More isoform RNF43 interacts with HAP95, a chromatin-associated protein interfacing the nuclear envelope. HAP95 is ubiquitinated and subjected to a proteasome-dependent degradation pathway, however, HAP95 is unlikely to serve as a substrate of RNF43 ubiquitin ligase Homo sapiens

Synonyms

Synonyms Comment Organism
RNF43
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the gene encoding RNF43 is upregulated in colon adenocarcinoma as well as in colon adenoma up