Literature summary for 2.3.2.27 extracted from

Kong, Q.; Zeng, W.; Wu, J.; Hu, W.; Li, C.; Mao, B.
RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination (2010), Biochem. Biophys. Res. Commun., 393, 708-713.

Search for more literature for 2.3.2.27

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	the RING domain is required for proper cellular localization	Mus musculus	5737	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q6PDX6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[RNF220-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [RF220]-L-lysine	-	Mus musculus	[RNF220-ubiquitin-carrier protein]-L-cysteine + [RNF220]-N6-ubiquitinyl-L-lysine	isoform RNF220 can bind ubiquitin-conjugating enzyme and mediate auto-ubiquitination of itself	?
[RNF220-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [Sin3B]-L-lysine	Sin3B, a global regulator of gene transcription, which serves as an essential scaffold protein of the Sin3/HDAC corepressor complex	Mus musculus	[RNF220-ubiquitin-carrier protein]-L-cysteine + [Sin3B]-N6-ubiquitinyl-L-lysine	isoform RNF220 specifically interacts with Sin3B both in vitro and in vivo. Sin3B can be regulated by the ubiquitin-proteasome system. Co-expression of RNF220 and Sin3B promotes the ubiquitination and proteasomal degradation of Sin3B	?

Synonyms

Synonyms	Comment	Organism
RNF220	-	Mus musculus

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Release 2023.1 (January 2023)