2.7.1.76: 2'-deoxyadenosine kinase
This is an abbreviated version!
For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.76
-
2.7.1.76
-
deaminase
-
deoxynucleoside
-
thymidine
-
acidophilus
-
5'-nucleotidase
-
hypoxanthine-guanine
-
ecto-5\'-nucleotidase
-
9-beta-d-arabinofuranosyladenine
-
mycoides
-
deoxycoformycin
-
2.7.1.20
-
heterotropic
-
medicine
- 2.7.1.76
- deaminase
- deoxynucleoside
- thymidine
- acidophilus
- 5'-nucleotidase
-
hypoxanthine-guanine
-
ecto-5\'-nucleotidase
- 9-beta-d-arabinofuranosyladenine
- mycoides
- deoxycoformycin
-
2.7.1.20
-
heterotropic
- medicine
Reaction
Synonyms
dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase
ECTree
2.7.1.76 2'-deoxyadenosine kinaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.1.76 - 2'-deoxyadenosine kinase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxyadenosine
2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
-
-
-
?
2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxycytidine
2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxyadenosine
2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
low activity
-
-
?
2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxycytidine
2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
low activity
-
-
?
2'-deoxyadenosine-3'-triphosphate + 2'-deoxyadenosine
2'-deoxyadenosine-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
-
-
-
?
2'-deoxyadenosine-3'-triphosphate + 2'-deoxycytidine
2'-deoxyadenosine-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine 2'-triphosphate + 2'-deoxyadenosine
3'-deoxyadenosine-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine 2'-triphosphate + 2'-deoxycytidine
3'-deoxyadenosine-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxyadenosine
3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxycytidine
3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxyadenosine
3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
-
-
-
?
3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxycytidine
3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
ATP + 1-beta-D-arabinofuranosyl cytosine
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
ATP + 1-beta-D-arabinofuranosyl uracil
ADP + 1-beta-D-arabinofuranosyl uracil 5'-phosphate
0.3% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
ADP + 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide 5'-monophosphate
-
trivial name ribavirin
-
?
ATP + 2',2'-difluoro-2'-deoxycytidine
ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
20% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',2'-difluoro-2'-deoxycytidine
ADP + 2',2'-difluoro-2'-deoxycytidine monophosphate
20% relative activity compared to deoxyadenosine
-
-
?
ATP + 2',2'-difluoro-2'-deoxyguanosine
ADP + 2',2'-difluoro-2'-deoxyguanosine 5'-phosphate
24% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',2'-difluoro-2'-deoxyguanosine
ADP + 2',2'-difluoro-2'-deoxyguanosine monophosphate
24% relative activity compared to deoxyadenosine
-
-
?
ATP + 2',3'-dideoxyadenosine
ADP + 2',3'-dideoxyadenosine 5'-monophosphate
1.5% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',3'-dideoxyadenosine
ADP + 2',3'-dideoxyadenosine monophosphate
1.5% relative activity compared to deoxyadenosine
-
-
?
ATP + 2',3'-dideoxycytidine
ADP + 2',3'-dideoxycytidine 5'-monophosphate
0.1% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',3'-dideoxyguanosine
ADP + 2',3'-dideoxyguanosine 5'-monophosphate
0.5% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',3'-dideoxyinoosine
ADP + 2',3'-dideoxyinosine 5'-monophosphate
3.9% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',3'-dideoxyinosine
ADP + 2',3'-dideoxyinosine 5'-phosphate
3.9% relative activity compared to deoxyadenosine
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
97% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2'-deoxyinosine
ADP + 2'-deoxyinosine 5'-phosphate
116% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
0.01% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
0.9% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2'-fluoro-arabinosyl adenine
ADP + 2'-fluoro-arabinosyl adenine 5'-monophosphate
15% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
111% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
ADP + 2-chloro-2'-deoxyadenosine monophosphate
111% relative activity compared to deoxyadenosine
-
-
?
ATP + 9-beta-D-arabinofuranosyl adenine
ADP + 9-beta-D-arabinofuranosyl adenine 5'-monophosphate
77% relative activity compared to deoxyadenosine
-
-
?
ATP + 9-beta-D-arabinofuranosyl adenine
ADP + 9-beta-D-arabinofuranosyl adenine 5'-phosphate
77% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 9-beta-D-arabinofuranosyl guanine
ADP + 9-beta-D-arabinofuranosyl guanine 5'-monophosphate
6% relative activity compared to deoxyadenosine
-
-
?
ATP + 9-beta-D-arabinofuranosyl guanine
ADP + 9-beta-D-arabinofuranosyl guanine 5'-phosphate
6% of the activity with 2'-deoxyadenosine
-
-
?
ATP + adenosine
ADP + adenosine 5'-monophosphate
7.4% of the activity with 2'-deoxyadenosine
-
-
?
ATP + arabinosyl-2-fluoroadenine
ADP + arabinosyl-2-fluoroadenine 5'-phosphate
-
-
-
-
?
ATP + arabinosyladenine
ADP + arabinosyladenine 5'-phosphate
-
-
-
-
?
ATP + cytidine
ADP + cytidine 5'-monophosphate
0.1% of the activity with 2'-deoxyadenosine
-
-
?
ATP + deoxycytosine
ADP + dCMP
81% relative activity compared to deoxyadenosine
-
-
?
ATP + deoxyinosine
ADP + dIMP
116% relative activity compared to deoxyadenosine
-
-
?
ATP + deoxyuridine
ADP + dUMP
0.9% relative activity compared to deoxyadenosine
-
-
?
ATP + guanosine
ADP + GMP
5.5% relative activity compared to deoxyadenosine
-
-
?
ATP + guanosine
ADP + guanosine 5'-monophosphate
5.5% of the activity with 2'-deoxyadenosine
-
-
?
ATP + inosine
ADP + IMP
5.9% relative activity compared to deoxyadenosine
-
-
?
ATP + inosine
ADP + inosine monophosphate
5.9% of the activity with 2'-deoxyadenosine
-
-
?
ATP + penciclovir
ADP + ?
1.4% relative activity compared to deoxyadenosine
-
-
?
CTP + 2'-deoxyadenosine
CDP + 2'-deoxyadenosine 5'-phosphate
CTP, 3% of the activity with ATP
-
-
?
dATP + deoxyadenosine
dADP + dAMP
2% activity compared to ATP
-
-
?
dCTP + deoxyadenosine
dCDP + dAMP
106% activity compared to ATP
-
-
?
triphosphate + 2'-deoxycytidine
diphosphate + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
UTP + 2'-deoxyadenosine
UDP + 2'-deoxyadenosine 5'-phosphate
UTP, 2% of the activity with ATP
-
-
?
ATP + 1-beta-D-arabinofuranosyl cytosine
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
3% relative activity compared to deoxyadenosine
-
-
?
ATP + 1-beta-D-arabinofuranosyl cytosine
ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
3% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2',2'-difluorodeoxycytidine
ADP + 2',2'-difluorodeoxycytidine 5'-phosphate
enzyme activates 2',2'-difluorodesoxycytidine in vivo
-
-
?
ATP + 2',2'-difluorodeoxycytidine
ADP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
81% of the activity with 2'-deoxyadenosine
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-fluoro-arabinosyl adenine
ADP + 2'-fluoro-arabinosyl adenine monophosphate
i.e. fludarabine
-
-
?
ATP + 2'-fluoro-arabinosyl adenine
ADP + 2'-fluoro-arabinosyl adenine monophosphate
15% relative activity compared to deoxyadenosine
-
-
?
ATP + adenosine
ADP + AMP
7.4% relative activity compared to deoxyadenosine
-
-
?
ATP + adenosine
ADP + AMP
-
kinetic data suggest that different catalytic sites of deoxyadenosine kinase or a different enzyme are responsible for deoxyadenosine and adenosine kinase activities
-
?
ATP + deoxyadenosine
ADP + 5'-dAMP
-
involved in biosynthesis of nucleoside monophosphates from preformed deoxyribonucleosides
-
?
ATP + deoxyadenosine
ADP + 5'-dAMP
-
key anabolic enzyme for activation of purine and pyrimidine deoxyribonucleosides as well as cytosine arabinoside and other anti-tumour drugs
-
?
ATP + deoxyadenosine
ADP + 5'-dAMP
dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism
-
?
ATP + deoxyadenosine
ADP + 5'-dAMP
dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism
-
?
ATP + deoxyadenosine
ADP + 5'-dAMP
-
involved in nucleoside metabolism
-
?
ATP + deoxyadenosine
ADP + dAMP
-
transfers a phospho group from specific nucleoside 5'-triphosphate donors to 5'-position of deoxyadenosine
-
?
ATP + deoxyadenosine
ADP + dAMP
-
no activity with adenosine and guanosine
-
?
ATP + deoxyadenosine
ADP + dAMP
-
enzyme has both adenosine kinase and deoxyadenosine kinase activity
-
?
ATP + deoxyadenosine
ADP + dAMP
-
enzyme bears two separate but interacting active sites for deoxyadenosine and deoxycytidine kinase activity
-
?
ATP + deoxyadenosine
ADP + dAMP
-
enzyme exists in two heterodimeric complexes, complex I: deoxycytidine/deoxyadenosine kinase and complex II: deoxyguanosine/deoxyadenosine kinase
-
?
ATP + deoxyadenosine
ADP + dAMP
-
enzyme exists in two heterodimeric complexes, complex I: deoxycytidine/deoxyadenosine kinase and complex II: deoxyguanosine/deoxyadenosine kinase
-
?
ATP + deoxyadenosine
ADP + dAMP
-
no activity with cytidine, uridine, guanosine, deoxyguanosine and thymidine
-
?
ATP + deoxycytidine
ADP + dCMP
-
approx. 12% of activity with deoxyadenosine
-
?
ATP + deoxycytidine
ADP + dCMP
-
deoxycytidine kinase is a multisubstrate enzyme that also phosphorylates deoxyadenosine, it exists in different conformational states with different substrate kinetic properties
-
?
ATP + deoxyguanosine
ADP + dGMP
-
approx. 40% of activity with deoxyadenosine
-
?
ATP + deoxyguanosine
ADP + dGMP
97% relative activity compared to deoxyadenosine
-
-
?
CTP + deoxyadenosine
CDP + dAMP
57% activity compared to ATP
-
-
?
dTTP + deoxyadenosine
dTDP + dAMP
44% activity compared to ATP
-
-
?
GTP + 2'-deoxyadenosine
GDP + 2'-deoxyadenosine 5'-phosphate
GTP, 14% of the activity with ATP
-
-
?
UTP + deoxyadenosine
UDP + dAMP
22% activity compared to ATP
-
-
?
additional information
?
-
-
substrate specificity, enzyme is specific for deoxyadenosine and deoxycytidine
-
-
?
additional information
?
-
-
cannot efficiently phosphorylate any other native deoxyribonucleoside than deoxyadenosine
-
-
?
additional information
?
-
cannot efficiently phosphorylate any other native deoxyribonucleoside than deoxyadenosine
-
-
?
additional information
?
-
-
enzyme cannot effectively phopshorylate any other native deoxyribonucleodie besides 2'-deoxyadenosine
-
-
?
additional information
?
-
enzyme cannot effectively phopshorylate any other native deoxyribonucleodie besides 2'-deoxyadenosine
-
-
?
additional information
?
-
-
no activity with diphosphate as phosphate donor, no activity with triphosphate and 2'-deoxyadenosine as substrates
-
-
?
additional information
?
-
-
less than 1% activity with dGTP, deoxyuridine, deoxythymidine, 1-beta-D-arabinofuranosyl uracil, 2',3'-dideoxyguanosine, 2',3'-dideoxycytidine, cytidine, acyclovir, ganciclovir, 2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil, and 5-fluoro-2'-deoxyuridine
-
-
?
additional information
?
-
less than 1% activity with dGTP, deoxyuridine, deoxythymidine, 1-beta-D-arabinofuranosyl uracil, 2',3'-dideoxyguanosine, 2',3'-dideoxycytidine, cytidine, acyclovir, ganciclovir, 2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil, and 5-fluoro-2'-deoxyuridine
-
-
?
