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2.7.1.76: 2'-deoxyadenosine kinase

This is an abbreviated version!
For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.

Word Map on EC 2.7.1.76

Reaction

ATP
+
2'-deoxyadenosine
=
ADP
+
dAMP

Synonyms

dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.76 2'-deoxyadenosine kinase

Engineering

Engineering on EC 2.7.1.76 - 2'-deoxyadenosine kinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D78A
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
D78E
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
D78N
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
D84A
mutation in dGK of dAK/dGK, increase of dAK activity
D84E
mutation in dGK of dAK/dGK, increase of dAK activity
D84N
mutation in dGK of dAK/dGK, increase of dAK activity
R79k
2 types of mutants, one bears the mutation on both the dAK and dGK subunits while the other, called R79K:dGK, has the mutation on the dGK subunit only, strong increase in dAK activity, activation of dAK by deoxyguanosine is nearly eliminated in the case of R79K:dGK, while for the tandem mutated R79K mutant a 30% inhibition is observed, inhibition by dATP is reduced
D78A
-
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
-
D78E
-
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
-
D78N
-
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
-
D84A
-
mutation in dGK of dAK/dGK, increase of dAK activity
-
D84E
-
mutation in dGK of dAK/dGK, increase of dAK activity
-
D84N
-
mutation in dGK of dAK/dGK, increase of dAK activity
-
R79k
-
2 types of mutants, one bears the mutation on both the dAK and dGK subunits while the other, called R79K:dGK, has the mutation on the dGK subunit only, strong increase in dAK activity, activation of dAK by deoxyguanosine is nearly eliminated in the case of R79K:dGK, while for the tandem mutated R79K mutant a 30% inhibition is observed, inhibition by dATP is reduced
-