2.7.1.76: 2'-deoxyadenosine kinase
This is an abbreviated version!
For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.76
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2.7.1.76
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deaminase
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deoxynucleoside
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thymidine
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acidophilus
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5'-nucleotidase
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hypoxanthine-guanine
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ecto-5\'-nucleotidase
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9-beta-d-arabinofuranosyladenine
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mycoides
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deoxycoformycin
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2.7.1.20
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heterotropic
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medicine
- 2.7.1.76
- deaminase
- deoxynucleoside
- thymidine
- acidophilus
- 5'-nucleotidase
-
hypoxanthine-guanine
-
ecto-5\'-nucleotidase
- 9-beta-d-arabinofuranosyladenine
- mycoides
- deoxycoformycin
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2.7.1.20
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heterotropic
- medicine
Reaction
Synonyms
dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase
ECTree
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Engineering
Engineering on EC 2.7.1.76 - 2'-deoxyadenosine kinase
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D78A
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
D78E
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
D78N
mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
R79k
2 types of mutants, one bears the mutation on both the dAK and dGK subunits while the other, called R79K:dGK, has the mutation on the dGK subunit only, strong increase in dAK activity, activation of dAK by deoxyguanosine is nearly eliminated in the case of R79K:dGK, while for the tandem mutated R79K mutant a 30% inhibition is observed, inhibition by dATP is reduced
D78A
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mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
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D78E
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mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
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D78N
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mutation on both subunits of dGK/dAK, 0.2% of wild-type dAK activity
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R79k
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2 types of mutants, one bears the mutation on both the dAK and dGK subunits while the other, called R79K:dGK, has the mutation on the dGK subunit only, strong increase in dAK activity, activation of dAK by deoxyguanosine is nearly eliminated in the case of R79K:dGK, while for the tandem mutated R79K mutant a 30% inhibition is observed, inhibition by dATP is reduced
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