2.7.1.76: 2'-deoxyadenosine kinase
This is an abbreviated version!
For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.76
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2.7.1.76
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deaminase
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deoxynucleoside
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thymidine
-
acidophilus
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5'-nucleotidase
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hypoxanthine-guanine
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ecto-5\'-nucleotidase
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9-beta-d-arabinofuranosyladenine
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mycoides
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deoxycoformycin
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2.7.1.20
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heterotropic
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medicine
- 2.7.1.76
- deaminase
- deoxynucleoside
- thymidine
- acidophilus
- 5'-nucleotidase
-
hypoxanthine-guanine
-
ecto-5\'-nucleotidase
- 9-beta-d-arabinofuranosyladenine
- mycoides
- deoxycoformycin
-
2.7.1.20
-
heterotropic
- medicine
Reaction
Synonyms
dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase
ECTree
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Crystallization
Crystallization on EC 2.7.1.76 - 2'-deoxyadenosine kinase
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three-dimensional structural model based on crystal structure of Mycoplasma mycoides deoxyadenosine kinase
in complex with deoxyadenosine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate, as well as with products 2'-deoxycytidine 5'-phosphate and 2'-deoxycytidine 5'-diphosphate. Both deoxyadenosine 5'-triphosphate and 2'-deoxycytidine 5'-triphosphate bind to the enzyme in a feedback-inhibitory manner with the deoxyribonucleoside part in the deoxyribonucleoside binding site and the triphosphates in the P-loop. Superposition with human counterparts deoxyguanosine kinase and deoxycytidine kinase. Overall structures are very similar with a few amino acid alterations in the proximity of the active site
sitting drop vapour diffusion method using 24% (w/v) PEG 3350 and 0.2 M KSCN