Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.1.76: 2'-deoxyadenosine kinase

This is an abbreviated version!
For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.

Word Map on EC 2.7.1.76

Reaction

ATP
+
2'-deoxyadenosine
=
ADP
 +
dAMP

Synonyms

dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.76 2'-deoxyadenosine kinase

Temperature Stability

Temperature Stability on EC 2.7.1.76 - 2'-deoxyadenosine kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
at pH 10 and 25°C, the soluble enzyme maintains 50% of the starting activity upon about 20 h incubation
37
-
t1/2: 2 h, 1 mM ATP, 0.5 mM dTTP, 1 mM deoxyadenosine or 0.25 3-[(3-cholamidopropyl)dimethylamino]-1-propanesulfonate stabilize
4
-
half-life of deoxyadenosine kinase activity: 1.5 days
42
-
first-order rate constant of inactivation: in the absence of dithiothreitol, 14.2/min, in the presence of 10 mM dithiothreitol, 6.82, substrate ribavirin
48
-
inactivation of deoxyadenosine kinase activity
50
-
80% loss of activity
additional information