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Literature summary for 2.7.1.76 extracted from

  • Ma, G.T.; Hong, Y.S.; Ives, D.H.
    Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26 (1995), J. Biol. Chem., 270, 6595-6601.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
deoxyguanosine 0.1 mM, 5fold activation of recombinant dAK Lactobacillus acidophilus

Cloned(Commentary)

Cloned (Comment) Organism
expression of dGK/dAK in Escherichia coli Lactobacillus acidophilus

Inhibitors

Inhibitors Comment Organism Structure
dATP 0.5 mM, 90% inhibition of recombinant dAK, end product inhibition Lactobacillus acidophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + deoxyadenosine Lactobacillus acidophilus dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism ADP + 5'-dAMP
-
?
ATP + deoxyadenosine Lactobacillus acidophilus ATCC 700396 dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism ADP + 5'-dAMP
-
?

Organism

Organism UniProt Comment Textmining
Lactobacillus acidophilus P0C1F9 strain R-26
-
Lactobacillus acidophilus ATCC 700396 P0C1F9 strain R-26
-

Purification (Commentary)

Purification (Comment) Organism
recombinant dGK/dAK, dATP-Sepharose affinity chromatography Lactobacillus acidophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + deoxyadenosine
-
Lactobacillus acidophilus ADP + dAMP
-
?
ATP + deoxyadenosine
-
Lactobacillus acidophilus ATCC 700396 ADP + dAMP
-
?
ATP + deoxyadenosine dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism Lactobacillus acidophilus ADP + 5'-dAMP
-
?
ATP + deoxyadenosine dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism Lactobacillus acidophilus ATCC 700396 ADP + 5'-dAMP
-
?

Subunits

Subunits Comment Organism
More dGK/dAK is composed of 2 nonidentical subunits of approx. 26000 Da Lactobacillus acidophilus

Synonyms

Synonyms Comment Organism
deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK
-
Lactobacillus acidophilus
deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK
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Lactobacillus acidophilus