Activating Compound | Comment | Organism | Structure |
---|---|---|---|
deoxyguanosine | 0.1 mM, 5fold activation of recombinant dAK | Lactobacillus acidophilus |
Cloned (Comment) | Organism |
---|---|
expression of dGK/dAK in Escherichia coli | Lactobacillus acidophilus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dATP | 0.5 mM, 90% inhibition of recombinant dAK, end product inhibition | Lactobacillus acidophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyadenosine | Lactobacillus acidophilus | dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism | ADP + 5'-dAMP | - |
? | |
ATP + deoxyadenosine | Lactobacillus acidophilus ATCC 700396 | dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism | ADP + 5'-dAMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lactobacillus acidophilus | P0C1F9 | strain R-26 | - |
Lactobacillus acidophilus ATCC 700396 | P0C1F9 | strain R-26 | - |
Purification (Comment) | Organism |
---|---|
recombinant dGK/dAK, dATP-Sepharose affinity chromatography | Lactobacillus acidophilus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyadenosine | - |
Lactobacillus acidophilus | ADP + dAMP | - |
? | |
ATP + deoxyadenosine | - |
Lactobacillus acidophilus ATCC 700396 | ADP + dAMP | - |
? | |
ATP + deoxyadenosine | dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism | Lactobacillus acidophilus | ADP + 5'-dAMP | - |
? | |
ATP + deoxyadenosine | dGK/dAK plays an essential role in generating the dexyribonucleotide precursors, dGTP and dATP, for DNA metabolism | Lactobacillus acidophilus ATCC 700396 | ADP + 5'-dAMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | dGK/dAK is composed of 2 nonidentical subunits of approx. 26000 Da | Lactobacillus acidophilus |
Synonyms | Comment | Organism |
---|---|---|
deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK | - |
Lactobacillus acidophilus |
deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK | - |
Lactobacillus acidophilus |