2.7.1.36: mevalonate kinase
This is an abbreviated version!
For detailed information about mevalonate kinase, go to the full flat file.
Word Map on EC 2.7.1.36
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2.7.1.36
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fever
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autoinflammatory
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cholesterol
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isoprenoids
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mediterranean
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aciduria
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hereditary
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receptor-associated
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hyperimmunoglobulinemia
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vinyl
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ketone
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cryopyrin-associated
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phosphomevalonate
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febrile
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igd
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isopentenyl
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monogenic
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farnesyl
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tnfrsf1a
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isoprene
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hyper-igd
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anakinra
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rash
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lymphadenopathy
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hmg-coa
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inflammasome
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geranylgeranylation
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amyloidosis
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aphthous
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porokeratosis
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arthralgia
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non-sterol
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pyoderma
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nod2
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papa
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autoinflammation
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gangrenosum
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canakinumab
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adenitis
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pstpip1
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hyperimmunoglobulin
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medicine
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hepatosplenomegaly
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cholesterogenesis
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etanercept
-
cryopyrin
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synthesis
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diagnostics
- 2.7.1.36
- fever
- autoinflammatory
- cholesterol
-
isoprenoids
-
mediterranean
- aciduria
- hereditary
-
receptor-associated
- hyperimmunoglobulinemia
-
vinyl
- ketone
-
cryopyrin-associated
- phosphomevalonate
-
febrile
- igd
-
isopentenyl
-
monogenic
-
farnesyl
-
tnfrsf1a
- isoprene
-
hyper-igd
-
anakinra
- rash
- lymphadenopathy
- hmg-coa
- inflammasome
-
geranylgeranylation
- amyloidosis
-
aphthous
- porokeratosis
- arthralgia
-
non-sterol
-
pyoderma
- nod2
- papa
- autoinflammation
- gangrenosum
-
canakinumab
- adenitis
-
pstpip1
-
hyperimmunoglobulin
- medicine
-
hepatosplenomegaly
-
cholesterogenesis
-
etanercept
-
cryopyrin
- synthesis
- diagnostics
Reaction
Synonyms
ATP: mevalonate 5-phosphotransferase, ATP:mevalonate 5-phosphotransferase, GbMVK, kinase, mevalonate (phosphorylating), mevalonate 5-phosphotransferase, mevalonate phosphokinase, mevalonic acid kinase, mevalonic kinase, MmMK, MVA kinase, MVK, SSO0383, TcMVK, TeMVK
ECTree
2.7.1.36 mevalonate kinaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.7.1.36 - mevalonate kinase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
25-hydroxycholesterol
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expression of mevalonate kinase is regulated by sterol response element-binding protein-1, which is sensitive to the cllular concentration of 25-hydroxycholesterol. Presence of 25-hydroxycholesterol inhibits mevalonate kinase expression and subsequently its binding to luteinizing hormone receptor mRNA
5-diphosphomevalonate
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allosteric and potent inhibition, the molecule functions as a partial bisubstrate analogue that elicits a ternary-complex-like form of the enzyme, binding structure, overview
5-phosphomevalonate
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product inhibition, non-competitive with ATP and mevalonate
estradiol
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together with follicle-stimulating hormone, decreases mevalonate kinase mRNA levels, resulting in up-regulation of luteinizing hormone receptor mRNA that is inversely correlated to mevalonate kinase mRNA expression
follicle-stimulating hormone
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together with estradiol, decreases mevalonate kinase mRNA levels, resulting in up-regulation of luteinizing hormone receptor mRNA that is inversely correlated to mevalonate kinase mRNA expression
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lovastatin
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inhibition of isoprenoid pathway, resulting in a dose-dependent reduction of amyloid formed compared with mononuclear cells that are exposed only to serum amyloid. The inhibitory effects of lovastatin are reversible by addition of farnesol but not geranylgeraniol. Farnesyl transferase inhibition also inhibits amyloidogenesis
diphosphomevalonate
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functions as a partial bisubstrate analogue and elicits a ternary-complex like form of the enzyme
mevalonate
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substrate inhibition at millimolar concentrations, 50% inhibition at 2.88 mM
mevalonate 5-phosphate
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noncompetitive vs. ATP, mixed-type vs. mevalonate
p-chloromercuribenzoate
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0.1 mM, 95% inhibition, 1 mM, complete inhibition
p-chloromercuribenzoate
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activity can be almost completely restored by incubation with an excess of cysteine
p-chloromercuribenzoate
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0.1 mM, 83% inhibition, completely reversed by reduced glutathione
additional information
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not inhibited by by isopentenyl diphosphate and dimethylallyl diphosphate
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additional information
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not inhibited by R-mevalonate 5-diphosphate, geraniol and dolichol up to 0.084, 0.226 and 0.68 mM, respectively
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additional information
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the enzyme is not inhibited by dimethylallyl diphosphate, geranyl diphosphate, farnesyl diphosphate, isopentenyl monophosphate, and diphosphomevalonate
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additional information
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organic synthesis of bisubstrate analogues, organic synthesis and biological characterization of bifunctional molecules, which can inhibit both MVK and mevalonate 5-diphosphate decarboxylase
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additional information
synthesis of a series of C3-substituted mevalonate analogues to probe the steric and electronic requirements of the mevalonate kinase active site for development of specific mechanism-based inhibitors, overview
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additional information
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synthesis of a series of C3-substituted mevalonate analogues to probe the steric and electronic requirements of the mevalonate kinase active site for development of specific mechanism-based inhibitors, overview
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additional information
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not inhibited by isopentenyl and dimethyldiphosphate and phosphate
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