General Stability | Organism |
---|---|
freezing of pure enzyme causes irreversible loss of activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
farnesyl diphosphate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.27 | - |
(RS)-mevalonate | pH 7.0, 25°C | Rattus norvegicus | |
1.75 | - |
ATP | pH 7.0, 25°C | Rattus norvegicus | |
1.75 | - |
ATP | ATP in form of MgATP2- | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39900 | - |
2 * 39900, SDS-PAGE | Rattus norvegicus |
86000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mevalonate | Rattus norvegicus | enzyme may play a key role in regulating cholesterol biosynthesis | ADP + phosphomevalonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate, Blue-Sepharose, ammonium sulfate, Sephadex G-150, ATP-agarose | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
31.67 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | - |
Rattus norvegicus | ADP + (R)-5-phosphomevalonate | - |
? | |
ATP + mevalonate | - |
Rattus norvegicus | ADP + phosphomevalonate | - |
? | |
ATP + mevalonate | enzyme may play a key role in regulating cholesterol biosynthesis | Rattus norvegicus | ADP + phosphomevalonate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 39900, SDS-PAGE | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
farnesyl diphosphate | pH 7.0, 25°C | Rattus norvegicus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Rattus norvegicus | isoelectric focusing | - |
6.2 |