2.7.1.138: ceramide kinase

This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.

Reaction

Synonyms

acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.138 ceramide kinase

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Results	in table
10	Activating Compound
1476	AA Sequence
9	Application
1	CAS Registry Number
31	Cloned(Commentary)
31	Cofactor
133	Disease/ Diagnostics
6	Expression
42	General Information
2	General Stability
2	IC50 Value
41	Inhibitors
3	Ki Value [mM]
26	KM Value [mM]
58	Localization
40	Metals/Ions
4	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
72	Organism
1	Oxidation Stability
3	Pathway
1	PDB ID
13	pH Optimum
2	pH Range
4	Posttranslational Modification
53	Protein Variants
10	Purification (Commentary)
3	Reaction
24	Reaction Type
67	Reference
128	Source Tissue
11	Specific Activity [micromol/min/mg]
3	Storage Stability
173	Substrates and Products (Substrate)
3	Subunits
72	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]

Expression

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Expression on EC 2.7.1.138 - ceramide kinase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

all-trans retinoic acid inhibits ceramide kinase transkription during neuronal differentiation of a human neuroblastoma cell line SH-SY5Y, inhibition of the transcriptional activity of the 5'-promoter of ceramide kinase. Retinol does not reduce CERK protein and mRNA level

Homo sapiens

Q8TCT0

699665

ceramide kinase expression shows no association with age, lymph node status and tumor size

Homo sapiens

-

699089

Cerk is rapidly upregulated in tumor cells following HER2/neu downregulation or treatment with adriamycin

Homo sapiens

Q8TCT0

737976

DCERK protein is expressed during all developmental stages

Drosophila melanogaster

-

701002

expression of the enzyme, after 24 h of treatment with 1alpha,25-dihydroxyvitamin D3 or its analogue ZK191784, is reduced by approximately 40 and 60%, respectively

Homo sapiens

Q8TCT0

723271

higher expression in estrogen receptor negative breast tumors, gene expression of ceramide kinase is associated with prognosis in breast cancer, high ceramide kinase expression is correlated with ErbB2 status

Homo sapiens

-

699089