Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Drosophila melanogaster | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | Drosophila melanogaster | ceramide is an important regulator of photoreceptor viability | ADP + ceramide 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | ceramide is an important regulator of photoreceptor viability | Drosophila melanogaster | ADP + ceramide 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide kinase | - |
Drosophila melanogaster |
CERK | - |
Drosophila melanogaster |
DCERK protein | - |
Drosophila melanogaster |
Organism | Comment | Expression |
---|---|---|
Drosophila melanogaster | DCERK protein is expressed during all developmental stages | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | a mutation in ceramide kinase specifically leads to proteolysis of NORPA, consequent loss of phosphoinositide-specific phospholipase C activity, and failure in light signal transduction, a significant increase in ceramide, resulting from lack of ceramide kinase, perturbs the membrane microenvironment of phosphatidylinositol-4,5-bisphosphate, altering its distribution | Drosophila melanogaster |
physiological function | ceramide kinase, is a novel regulator of phosphoinositide-specific phospholipase C signaling and photoreceptor homeostasis, DCERK has a diacylglycerol kinase domain and a Ca2+/calmodulin binding domain | Drosophila melanogaster |