2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
-
pleckstrin
-
cerkl
- medicine
-
ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
ECTree
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Specific Activity
Specific Activity on EC 2.7.1.138 - ceramide kinase
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0.92 - 5.4
recombinant enzyme in CHO cell extract, substrate N-C6-D-erythro-sphingenine
additional information
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the specific CERK activity in cells exposed for 16-18 h to 0.005 mM C6-ceramide dropped to 18.7%
additional information
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assay development utilizing Triton X-100 mixed micelles with cardiolipin, beta-octylglucoside, and diethylene pentaacetic acid
additional information
enzyme activity is decreased during all-trans retinoic acid-induced neuronal differentiation of SH-SY5Y cells, all-trans retinoic acid reduces CERK protein and mRNA level in a time- and concentration-dependent manner, all-trans retinoic acid reduces cellular enzyme product ceramide 1-phosphate to 60% of control cells
additional information
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enzyme activity is decreased during all-trans retinoic acid-induced neuronal differentiation of SH-SY5Y cells, all-trans retinoic acid reduces CERK protein and mRNA level in a time- and concentration-dependent manner, all-trans retinoic acid reduces cellular enzyme product ceramide 1-phosphate to 60% of control cells