2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
-
pleckstrin
-
cerkl
- medicine
-
ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
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Reaction
Reaction on EC 2.7.1.138 - ceramide kinase
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ATP + ceramide = ADP + ceramide 1-phosphate
Leu10 in the pleckstrin homology domain of the enzyme is crucial for catalytic activity
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ATP + ceramide = ADP + ceramide 1-phosphate
the secondary hydroxy group is not required for substrate recognition, preference for the D-erythro isomer, the enzyme is specific for th phosphorylation of the 1-hydroxy group