2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
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pleckstrin
-
cerkl
- medicine
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ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
ECTree
2.7.1.138 ceramide kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.138 - ceramide kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + N-hexadecanoyl-sphingenine
ADP + N-hexadecanoyl-sphingenine 1-phosphate
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?
ATP + ceramide
ADP + ceramide 1-phosphate
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ceramide is an important regulator of photoreceptor viability
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?
ATP + ceramide
ADP + ceramide 1-phosphate
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ceramide 1-phosphate is a lipid signalling molecule involved in regulation of many physiological processes related to cell proliferation, apoptosis, and inflammation, most of them in concert with sphingosine 1-phosphate, ceramide 1-phosphate might act via extracellular cell surface receptors or intracellularly as second messenger
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?
ATP + ceramide
ADP + ceramide 1-phosphate
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synthesis of the sphingolipid signaling molecule
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?
ATP + ceramide
ADP + ceramide 1-phosphate
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?
ATP + ceramide
ADP + ceramide 1-phosphate
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ceramide phosphorylation may be associated with neurotransmitter release
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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CERK and its product Cer-1-P are implicated in signaling processes, Cer-1-P stimulates DNA synthesis
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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ceramide is a key mediator of cellular apoptosis
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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ceramide kinase is a critical mediator of eicosanoid synthesis, and its product, ceramide 1-phosphate, is required for the production of prostaglandins in response to several inflammatory agonists, CERK requires ceramide actively transported to the trans-Golgi network via ceramide transport protein CERT
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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ceramide kinase is important for cellular proliferation and survival, activation of cytosolic phospholipase A2, mast cell degranulation, and phagocytosis
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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CERK and C1P are playing significant biological roles in cell-signaling cascades
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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CerK has important roles in leukocyte functions, including the role in degranulation of mast cells and the phagocytosis of polymorphonuclear leukocytes
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?
ceramide + ATP
ceramide 1-phosphate + ADP
CERK plays a role in cell signalling
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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increased ceramide 1-phosphate during phagocytosis enhances phagocytosis and phagolysosome formation in COS-1 cells expressing hCERK
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?
ceramide + ATP
ceramide 1-phosphate + ADP
involvement in inflammatory processes and cell growth
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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key enzyme for controlling ceramide levels
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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ceramide kinase is not the only source of ceramide 1-phosphate, ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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CerK and C1P are involved in many cell functions, including membrane fusion, phagocytosis and degranulation in mast cells
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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CerK is not necessary for survival but might participate in neuronal functions involving emotional behavior
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?
ceramide + ATP
ceramide 1-phosphate + ADP
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CerK is involved in the regulation of mast cells
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?
additional information
?
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the enzyme does not play a role in neutrophil priming, the enzyme regulates the activity and translocalization of cytosolic phospholipase isozyme A2alpha, overview, the enzyme is involved in prostaglandin biosynthesis, i.e. intracellular arachidonic acid production, which is blocked by enzyme gene silencing
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?
additional information
?
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the enzyme is a critical mediator of eicosanoid synthesis
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?
additional information
?
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the enzyme is a mediator of calcium-dependent degranulation in mast cells
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?
