2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
-
pleckstrin
-
cerkl
- medicine
-
ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
ECTree
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Metals Ions
Metals Ions on EC 2.7.1.138 - ceramide kinase
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Ca2+
Mg2+
Ca2+
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required for activity, 60 nM - 3 mM, 20fold linear increase in activity, progressive loss of activity at higher concentrations
Ca2+
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completely dependent on, regulatory function for enzyme activity, calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium-sensor
Ca2+
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optimal activation at 1 mM, enzyme is a mediator of calcium-dependent degranulation in mast cells
Ca2+
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the intracellular calcium chelator BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) decreases ceramide 1-phosphate formation by almost 100%, demonstrating the total dependence of ceramide kinase on Ca2+-ions
Ca2+
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0.0001-0.0005 mM, 15-20fold increase in activity, 0.0005 mM, 60fold stimulation
Mg2+
the recombinant enzyme is highly dependent on Mg2+, at 3 mM MgCl2, preferred divalent cation