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Literature summary for 2.7.1.138 extracted from

  • Payne, A.W.; Pant, D.K.; Pan, T.C.; Chodosh, L.A.
    Ceramide kinase promotes tumor cell survival and mammary tumor recurrence (2014), Cancer Res., 74, 6352-6363.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme is a therapeutical target in breast cancer treatment due to its functional role in breast cancer recurrence Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Homo sapiens
-
ADP + ceramide 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TCT0 gene CERK
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell CERK expression is associated with an increased risk of recurrence in women with breast cancer Homo sapiens
-
BT-20 cell
-
Homo sapiens
-
BT-474 cell
-
Homo sapiens
-
SKBR-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
Homo sapiens ADP + ceramide 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
CERK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Cerk is rapidly upregulated in tumor cells following HER2/neu downregulation or treatment with adriamycin down

General Information

General Information Comment Organism
physiological function ceramide kinase promotes tumor cell survival and mammary tumor recurrence. Ceramide kinase is required for mammary tumor recurrence following HER2/neu pathway inhibition and is spontaneously upregulated during tumor recurrence in multiple genetically engineered mouse models for breast cancer. CERK expression is associated with an increased risk of recurrence in women with breast cancer, Cerk promotes tumor cell survival in vivo Homo sapiens