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Version 2014-12-22
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Details for prostaglandin-E2 9-reductase activity
1.1.1.189
Gene ontology ID
GO:0050221
Definition
Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
Synonyms
1. (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity
2. 9-keto-prostaglandin E(2) reductase activity
3. 9-keto-prostaglandin E2 reductase activity
4. 9-ketoprostaglandin reductase activity
5. PGE(2) 9-ketoreductase activity
6. PGE(2) 9-oxoreductase activity
7. PGE-9-ketoreductase activity
8. PGE2 9-ketoreductase activity
9. PGE2 9-oxoreductase activity
10. PGE2-9-ketoreductase activity
11. PGE2-9-OR
12. prostaglandin E 9-ketoreductase activity
13. prostaglandin E2-9-oxoreductase activity
14. prostaglandin-E(2) 9-oxoreductase activity
15. prostaglandin-E2 9-oxoreductase activity
16. reductase, 15-hydroxy-9-oxoprostaglandin
References
1. EC 1.1.1.189
2. MetaCyc PROSTAGLANDIN-E2-9-REDUCTASE-RXN
3. Reactome: R-HSA-2161651 "PGE2 is converted to PGF2a by CBR1"
4. RHEA: 24508
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