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Version 2014-12-22
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Details for C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
1.1.1.170, 1.1.1
Gene ontology ID
GO:0000252
Definition
Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H
Comment
Note that zymosterol is cholesta-8,24-dien-3-ol.
Synonyms
1. 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
2. 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
3. 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
4. 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity
5. C-3 sterol dehydrogenase (C-4 decarboxylase) activity
6. C-3 sterol dehydrogenase activity
7. sterol 4alpha-carboxylic decarboxylase activity
8. sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity
9. sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
References
1. EC 1.1.1.170
2. PMID 9811880
3. EC 1.1.1
4. Reactome: R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one"
5. Reactome: R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)"
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