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Version 2014-12-22
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Details for hydroxymethylglutaryl-CoA reductase (NADPH) activity
1.1.1.34
Gene ontology ID
GO:0004420
Definition
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
Synonyms
1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
2. HMG-CoA reductase activity
References
1. EC 1.1.1.34
2. RHEA: 15989
3. KEGG REACTION: R02082
4. MetaCyc 1.1.1.34-RXN
5. Reactome: R-HSA-191352 "Reduction of HMG-CoA produces mevalonate"
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