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Gene ontology
Version 2014-12-22
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Details for 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
Gene ontology ID
Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+
1. (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity
2. 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity
3. 15-hydroxyprostaglandin dehydrogenase activity
4. 15-hydroxyprostanoic dehydrogenase activity
5. 15-OH-PGDH
6. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)
7. NAD-specific 15-hydroxyprostaglandin dehydrogenase activity
8. prostaglandin dehydrogenase activity
1. EC
2. MetaCyc
3. Reactome: R-HSA-2161662 "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD"
4. Reactome: R-HSA-2161779 "LXA4 is oxidised to 15k-LXA4 by HPGD"
5. Reactome: R-HSA-9023968 "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1"
6. Reactome: R-HSA-9024766 "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1"
7. RHEA: 11876
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