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Version 2014-12-22
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Details for 3-hydroxyacyl-CoA dehydrogenase activity
1.1.1.35
Gene ontology ID
GO:0003857
Definition
Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)
Comment
See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'.
Synonyms
1. 3-oxoacyl-thioester reductase activity
2. beta-hydroxyacyl dehydrogenase activity
3. beta-hydroxyacyl-coenzyme A synthetase activity
4. beta-hydroxyacylcoenzyme A dehydrogenase activity
5. beta-hydroxybutyrylcoenzyme A dehydrogenase activity
6. beta-keto-reductase activity
7. beta-ketoacyl-CoA reductase
8. L-3-hydroxyacyl CoA dehydrogenase activity
9. L-3-hydroxyacyl coenzyme A dehydrogenase activity
References
1. EC 1.1.1.35
2. MetaCyc OHACYL-COA-DEHYDROG-RXN
3. Reactome: R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA"
4. Reactome: R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA"
5. Reactome: R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+"
6. Reactome: R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA"
7. Reactome: R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+"
8. Reactome: R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA"
9. Reactome: R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+"
10. Reactome: R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H"
11. Reactome: R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H"
12. Reactome: R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H"
13. Reactome: R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H"
14. Reactome: R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H"
15. Reactome: R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H"
16. Reactome: R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H"
17. RHEA: 22432
18. UM-BBD enzymeID: e0664
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