Reference on EC 3.4.21.21 - coagulation factor VIIa
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zur, M.; Nemersom, Y.
The esterase activity of coagulation factor VII. Evidence for intrinsic activity of the zymogen
J. Biol. Chem.
253
2203-2209
1978
Bos taurus
Broze, G.J.; Majerus, P.W.
Purification and properties of human coagulation factor VII
J. Biol. Chem.
255
1242-1247
1990
Homo sapiens
Radcliffe, R.; Nemerson, Y.
Activation and control of factor VII by activated factor X and thrombin. Isolation and characterization of a single chain form of factor VII
J. Biol. Chem.
250
388-395
1975
Bos taurus
Kisiel, W.; Davie, E.W.
Isolation and characterization of bovine factor VII
Biochemistry
14
4928-4934
1975
Bos taurus
Kemball-Cook, G.; Johnson, D.J.D.; Tuddenham, E.G.D.; Harlos, K.
Crystal structure of active site-directed human coagulation factor VIIa (des-Gla)
J. Struct. Biol.
127
213-223
1999
Homo sapiens
Thiruvikraman, S.V.; Roboz, J.; Wang, T.; Ma, L.; Seaman, G.; Guha, A.
Characterization of digoxigenin derivatives of human coagulation factors VIIa and X by electrospray mass spectrometry
Rapid Commun. Mass Spectrom.
10
1367-1370
1996
Homo sapiens
Petersen, L.C.; Persson, E.; Fresgard, P.O.
Thermal effects on an enzymatically latent conformation of coagulation factor VIIa
Eur. J. Biochem.
261
124-129
1999
Homo sapiens
Banner, D.W.; D'Arcy, A.; Chene, C.; Winkler, F.K.; Guha, A.; Konigsberg, W.H.; Nemerson, Y.; Kirchhofer, D.
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
Nature
380
41-46
1996
Homo sapiens
Shobe, J.; Dickinson, C.D.; Ruf, W.
Regulation of the catalytic function of coagulation factor VIIa by a conformational linkage of surface residue Glu 154 to the active site
Biochemistry
38
2745-2751
1999
Homo sapiens
Pike, A.C.W.; Brzozowski, A.M.; Roberts, S.M.; Olsen, O.H.; Persson, E.
Structure of human factor VIIa and its implications for the triggering of blood coagulation
Proc. Natl. Acad. Sci. USA
96
8925-8930
1999
Homo sapiens (P08709), Homo sapiens
Neuenschwander, P.F.; Morrissey, J.H.
Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: importance of amino acid residue K
Biochemistry
34
8701-8707
1995
Homo sapiens
Toso, R.; Pinotti, M.; High, K.A.; Pollak, E.S.; Bernardi, F.
A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates
Biochem. J.
363
411-416
2002
Homo sapiens
Toso, R.; Bernardi, F.; Tidd, T.; Pinotti, M.; Camire, R.M.; Marchetti, G.; High, K.A.; Pollak, E.S.
Factor VII mutant V154G models a zymogen-like form of factor VIIa
Biochem. J.
369
563-571
2003
Homo sapiens
Jin, J.; Chang, J.; Stafford, D.W.; Straight, D.L.
Residues Y179 and H101 of a hydrophobic patch of factor VII are involved in activation by factor Xa
Biochemistry
40
11405-11410
2001
Homo sapiens
Persson, E.; Nielsen, L.S.; Olsen, O.H.
Substitution of aspartic acid for methionine-306 in factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor
Biochemistry
40
3251-3256
2001
Homo sapiens
Dennis, M.S.; Roberge, M.; Quan, C.; Lazarus, R.A.
Selection and characterization of a new class of peptide exosite inhibitors of coagulation factor VIIa
Biochemistry
40
9513-9521
2001
Homo sapiens
Neuenschwander, P.F.; Vernon, J.T.; Morrissey, J.H.
Tissue factor alters the pKa values of catalytically important factor VIIa residues
Biochemistry
41
3364-3371
2002
Homo sapiens
Petrovan, R.J.; Ruf, W.
Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition
Biochemistry
41
9302-9309
2002
Homo sapiens
Soejima, K.; Mizuguchi, J.; Yuguchi, M.; Nakagaki, T.; Higashi, S.; Iwanaga, S.
Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property
J. Biol. Chem.
276
17229-17235
2001
Homo sapiens
Persson, E.; Bak, H.; Olsen, O.H.
Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity
J. Biol. Chem.
276
29195-29199
2001
Homo sapiens
Nelsestuen, G.L.; Stone, M.; Martinez, M.B.; Harvey, S.B.; Foster, D.; Kisiel, W.
Elevated function of blood clotting factor VIIa mutants that have enhanced affinity for membranes: behavior in a diffusion-limited reaction
J. Biol. Chem.
276
39825-39831
2001
Homo sapiens
Petrovan, R.J.; Ruf, W.
Residue Met(156) contributes to the labile enzyme conformation of coagulation factor VIIa
J. Biol. Chem.
276
6616-6620
2001
Homo sapiens
Maun, H.R.; Eigenbrot, C.; Lazarus, R.A.
Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage
J. Biol. Chem.
278
21823-21830
2003
Homo sapiens
Parlow, J.J.; Dice, T.A.; Lachance, R.M.; Girard, T.J.; Stevens, A.M.; Stegeman, R.A.; Stallings, W.C.; Kurumbail, R.G.; South, M.S.
Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors
J. Med. Chem.
46
4043-4049
2003
Homo sapiens
Parlow, J.J.; Case, B.L.; Dice, T.A.; Fenton, R.L.; Hayes, M.J.; Jones, D.E.; Neumann, W.L.; Wood, R.S.; Lachance, R.M.; Girard, T.J.; Nicholson, N.S.; Clare, M.; Stegeman, R.A.; Stevens, A.M.; Stallings, W.C.; Kurumbail, R.G.; South, M.S.
Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex
J. Med. Chem.
46
4050-4062
2003
Homo sapiens
Parlow, J.J.; Stevens, A.M.; Stegeman, R.A.; Stallings, W.C.; Kurumbail, R.G.; South, M.S.
Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors
J. Med. Chem.
46
4297-4312
2003
Homo sapiens
Parlow, J.J.; Kurumbail, R.G.; Stegeman, R.A.; Stevens, A.M.; Stallings, W.C.; South, M.S.
Design, Synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors
J. Med. Chem.
46
4696-4701
2003
Homo sapiens
Sichler, K.; Banner, D.W.; D'Arcy, A.; Hopfner, K.P.; Huber, R.; Bode, W.; Kresse, G.B.; Kopetzki, E.; Brandstetter, H.
Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions
J. Mol. Biol.
322
591-603
2002
Homo sapiens (P08709)
Dennis, M.S.; Eigenbrot, C.; Skelton, N.J.; Ultsch, M.H.; Santell, L.; Dwyer, M.A.; O'Connell, M.P.; Lazarus, R.A.
Peptide exosite inhibitors of factor VIIa as anticoagulants
Nature
404
465-470
2000
Homo sapiens (P08709)
Persson, E.; Kjalke, M.; Olsen, O.H.
Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity
Proc. Natl. Acad. Sci. USA
98
13583-13588
2001
Homo sapiens
Petersen, L.C.; Olsen, O.H.; Nielsen, L.S.; Freskgard, P.O.; Persson, E.
Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor
Protein Sci.
9
859-866
2000
Homo sapiens
Eigenbrot, C.; Kirchhofer, D.; Dennis, M.S.; Santell, L.; Lazarus, R.A.; Stamos, J.; Ultsch, M.H.
The factor VII zymogen structure reveals reregistration of beta strands during activation
Structure
9
627-636
2001
Homo sapiens
Carr, M.E., Jr.; Martin, E.J.; Kuhn, J.G.; Seremetis, S.V.
Effects of recombinant factor VIIa on platelet function and clot structure in blood with deficient prothrombin conversion
Thromb. Haemost.
89
803-811
2003
Homo sapiens
Persson, E.
Macromolecular substrate affinity for free factor VIIa is independent of a buried protease domain N-terminus
Biochem. Biophys. Res. Commun.
341
28-32
2006
Homo sapiens
Persson, E.; Bak, H.; Ostergaard, A.; Olsen, O.H.
Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement
Biochem. J.
379
497-503
2004
Homo sapiens
Kelley, R.F.; Yang, J.; Eigenbrot, C.; Moran, P.; Peek, M.; Lipari, M.T.; Kirchhofer, D.
Similar molecular interactions of factor VII and factor VIIa with the tissue factor region that allosterically regulates enzyme activity
Biochemistry
43
1223-1229
2004
Homo sapiens
Olsen, O.H.; Nielsen, P.F.; Persson, E.
Prevention of beta strand movement into a zymogen-like position does not confer higher activity to coagulation factor VIIa
Biochemistry
43
14096-14103
2004
Homo sapiens
Stone, M.D.; Harvey, S.B.; Martinez, M.B.; Bach, R.R.; Nelsestuen, G.L.
Large enhancement of functional activity of active site-inhibited factor VIIa due to protein dimerization: insights into mechanism of assembly/disassembly from tissue factor
Biochemistry
44
6321-6330
2005
Homo sapiens
Hathcock, J.J.; Rusinova, E.; Gentry, R.D.; Andree, H.; Nemerson, Y.
Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions
Biochemistry
44
8187-8197
2005
Homo sapiens
Kolesnikov, A.; Rai, R.; Young, W.B.; Mordenti, J.; Liu, L.; Torkelson, S.; Shrader, W.D.; Leahy, E.M.; Hu, H.; Gjerstad, E.; Janc, J.; Katz, B.A.; Sprengeler, P.A.
Factor VIIa inhibitors: improved pharmacokinetic parameters
Bioorg. Med. Chem. Lett.
16
2243-2246
2006
Rattus norvegicus
Morris, D.R.; Ding, Y.; Ricks, T.K.; Gullapalli, A.; Wolfe, B.L.; Trejo, J.
Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells
Cancer Res.
66
307-314
2006
Homo sapiens
Versteeg, H.H.; Spek, C.A.; Slofstra, S.H.; Diks, S.H.; Richel, D.J.; Peppelenbosch, M.P.
FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production
Circ. Res.
94
1032-1040
2004
Homo sapiens
Sethi, A.S.; Lees, D.M.; Douthwaite, J.A.; Corder, R.
Factor VIIa stimulates endothelin-1 synthesis in TNF-primed endothelial cells by activation of protease-activated receptor 2
Clin. Sci.
108
255-263
2005
Homo sapiens
Banerjee, Y.; Mizuguchi, J.; Iwanaga, S.; Kini, R.M.
Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity
J. Biol. Chem.
280
42601-42611
2005
Homo sapiens
Olivero, A.G.; Eigenbrot, C.; Goldsmith, R.; Robarge, K.; Artis, D.R.; Flygare, J.; Rawson, T.; Sutherlin, D.P.; Kadkhodayan, S.; Beresini, M.; Elliott, L.O.; DeGuzman, G.G.; Banner, D.W.; Ultsch, M.; Marzec, U.; Hanson, S.R.; Refino, C.; Bunting, S.; Kirchhofer, D.
A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo
J. Biol. Chem.
280
9160-9169
2005
Homo sapiens (P08709)
Rand, K.D.; Jorgensen, T.J.; Olsen, O.H.; Persson, E.; Jensen, O.N.; Stennicke, H.R.; Andersen, M.D.
The allosteric activation of coagulation factor VIIa visualized by hydrogen exchange
J. Biol. Chem.
281
23018-23024
2006
Homo sapiens
Chi, L.; Gibson, G.; Peng, Y.W.; Bousley, R.; Brammer, D.; Rekhter, M.; Chen, J.; Leadley, R.
Characterization of a tissue factor/factor VIIa-dependent model of thrombosis in hypercholesterolemic rabbits
J. Thromb. Haemost.
2
85-92
2004
Oryctolagus cuniculus
Gosalia, D.N.; Salisbury, C.M.; Ellman, J.A.; Diamond, S.L.
High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays
Mol. Cell. Proteomics
4
626-636
2005
Homo sapiens
Sutherland, M.R.; Friedman, H.M.; Pryzdial, E.L.
Herpes simplex virus type 1-encoded glycoprotein C enhances coagulation factor VIIa activity on the virus
Thromb. Haemost.
92
947-955
2004
Homo sapiens
Larsen, K.S.; stergaard, H.; Bjelke, J.R.; Olsen, O.H.; Rasmussen, H.B.; Christensen, L.; Kragelund, B.B.; Stennicke, H.R.
Engineering the substrate and inhibitor specificities of human coagulation factor VIIa
Biochem. J.
405
429-438
2007
Homo sapiens
Franchini, M.; Manzato, F.; Salvagno, G.L.; Lippi, G.
Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review
Blood Coagul. Fibrinolysis
18
589-593
2007
Homo sapiens
Taketomi, T.; Szlam, F.; Bader, S.O.; Sheppard, C.A.; Levy, J.H.; Tanaka, K.A.
Effects of recombinant activated factor VII on thrombin-mediated feedback activation of coagulation
Blood Coagul. Fibrinolysis
19
135-141
2008
Homo sapiens
Olsen, O.H.; Persson, E.
Cofactor-induced and mutational activity enhancement of coagulation factor VIIa
Cell. Mol. Life Sci.
65
953-963
2008
Homo sapiens
Colognesi, I.; Pasquali, V.; Foa, A.; Renzi, P.; Bernardi, F.; Bertolucci, C.; Pinotti, M.
Temporal variations of coagulation factor VII activity in mice are influenced by lighting regime
Chronobiol. Int.
24
305-313
2007
Mus musculus
Bjelke, J.R.; Persson, E.; Rasmussen, H.B.; Kragelund, B.B.; Olsen, O.H.
A loop of coagulation factor VIIa influencing macromolecular substrate specificity
FEBS Lett.
581
71-76
2007
Homo sapiens
Bosinski, T.J.; El Solh, A.A.
Recombinant factor VIIa, its clinical properties, and the tissue factor pathway of coagulation
Mini Rev. Med. Chem.
6
1111-1117
2006
Homo sapiens
Ahamed, J.; Versteeg, H.H.; Kerver, M.; Chen, V.M.; Mueller, B.M.; Hogg, P.J.; Ruf, W.
Disulfide isomerization switches tissue factor from coagulation to cell signaling
Proc. Natl. Acad. Sci. USA
103
13932-13937
2006
Homo sapiens
Olsen, O.H.; Rand, K.D.; stergaard, H.; Persson, E.
A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation
Protein Sci.
16
671-682
2007
Homo sapiens
Ohkubo, Y.Z.; Tajkhorshid, E.
Distinct structural and adhesive roles of Ca2+ in membrane binding of blood coagulation factors
Structure
16
72-81
2008
Homo sapiens
Karatela, R.A.; Sainani, G.S.
Interrelationship between coagulation factor VII and obesity in diabetes mellitus (type 2)
Diabetes Res. Clin. Pract.
84
e41-e44
2009
Homo sapiens
Fenaille, F.; Groseil, C.; Ramon, C.; Riande, S.; Siret, L.; Chtourou, S.; Bihoreau, N.
Mass spectrometric characterization of N- and O-glycans of plasma-derived coagulation factor VII
Glycoconj. J.
25
827-842
2008
Homo sapiens
Xu, H.; Noria, F.; Sandoval-Cooper, M.J.; Menchen, H.; Donahue, D.L.; Ploplis, V.A.; Castellino, F.J.
Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice
J. Pathol.
217
362-371
2009
Mus musculus
Bolt, G.; Kristensen, C.; Steenstrup, T.D.
More than one intracellular processing bottleneck delays the secretion of coagulation factor VII
Thromb. Haemost.
100
204-210
2008
Homo sapiens
Shinagawa, K.; Ploplis, V.A.; Castellino, F.J.
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L763-L770
2009
Homo sapiens, Mus musculus
Athanasiadis, G.; Esteban, E.; Gaya-Vidal, M.; Dugoujon, J.M.; Moschonas, N.; Chaabani, H.; Bissar-Tadmouri, N.; Harich, N.; Stoneking, M.; Moral, P.
Different evolutionary histories of the coagulation factor VII gene in human populations?
Ann. Hum. Genet.
74
34-45
2010
Homo sapiens
Masroori, N.; Halabian, R.; Mohammadipour, M.; Roushandeh, A.M.; Rouhbakhsh, M.; Najafabadi, A.J.; Fathabad, M.E.; Salimi, M.; Shokrgozar, M.A.; Roudkenar, M.H.
High-level expression of functional recombinant human coagulation factor VII in insect cells
Biotechnol. Lett.
32
803-809
2010
Homo sapiens (P08709), Homo sapiens
Pinotti, M.; Balestra, D.; Rizzotto, L.; Maestri, I.; Pagani, F.; Bernardi, F.
Rescue of coagulation factor VII function by the U1+5A snRNA
Blood
113
6461-6464
2009
Mus musculus
Woodruff, S.I.; Dougherty, A.L.; Dye, J.L.; Mohrle, C.R.; Galarneau, M.R.
Use of recombinant factor VIIA for control of combat-related haemorrhage
Emerg. Med. J.
27
121-124
2010
Homo sapiens
Persson, E.; Olsen, O.H.
Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa
FEBS J.
276
3099-3109
2009
Homo sapiens (P08709)
Pinotti, M.; Bertolucci, C.; Frigato, E.; Branchini, A.; Cavallari, N.; Baba, K.; Contreras-Alcantara, S.; Ehlen, C.; Bernardi, F.; Paul, K.N.; Tosini, G.
Chronic sleep deprivation markedly reduces coagulation factor VII expression
Haematologica
95
1429-1432
2010
Mus musculus
Mei, H.; Hu, Y.; Wang, H.; Shi, W.; Deng, J.; Guo, T.
Binding of EGF1 domain peptide in coagulation factor VII with tissue factor and its implications for the triggering of coagulation
J. Huazhong Univ. Sci. Technol. Med. Sci.
30
42-47
2010
Homo sapiens
Beier, U.H.; Schmidt, M.L.; Hast, H.; Kecskes, S.; Valentino, L.A.
Control of disseminated intravascular coagulation in Klippel-Trenaunay-Weber syndrome using enoxaparin and recombinant activated factor VIIa: a case report
J. Med. Case Rep.
4
92
2010
Homo sapiens
Funami, J.; Hayashi, T.; Nomura, H.; Ding, Q.F.; Ishitsuka-Watanabe, A.; Matsui-Hirai, H.; Ina, K.; Zhang, J.; Yu, Z.Y.; Iguchi, A.
Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women
Life Sci.
85
316-321
2009
Homo sapiens (P08709), Homo sapiens
Persson, E.; Bolt, G.; Steenstrup, T.D.; Ezban, M.
Recombinant coagulation factor VIIa--from molecular to clinical aspects of a versatile haemostatic agent
Thromb. Res.
125
483-489
2010
Homo sapiens (P08709)
Karatela, R.; Sainani, G.
Interrelationships of factor VII activity and plasma leptin with insulin resistance in coronary heart disease
Atherosclerosis
209
235-240
2010
Homo sapiens
Balandina, A.N.; Shibeko, A.M.; Kireev, D.A.; Novikova, A.A.; Shmirev, I.I.; Panteleev, M.A.; Ataullakhanov, F.I.
Positive feedback loops for factor V and factor VII activation supply sensitivity to local surface tissue factor density during blood coagulation
Biophys. J.
101
1816-1824
2011
Homo sapiens
Chuansumrit, A.; Teeraratkul, S.; Wanichkul, S.; Treepongkaruna, S.; Sirachainan, N.; Pakakasama, S.; Nuntnarumit, P.; Hongeng, S.; Hongeng, S.
Recombinant-activated factor VII for control and prevention of hemorrhage in nonhemophilic pediatric patients
Blood Coagul. Fibrinolysis
21
354-362
2010
Homo sapiens
Margaritis, P.; Roy, E.; Faella, A.; Downey, H.D.; Ivanciu, L.; Pavani, G.; Zhou, S.; Bunte, R.M.; High, K.A.
Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo
Blood
117
3974-3982
2011
Mus musculus
Shiraishi, T.; Kadono, S.; Haramura, M.; Kodama, H.; Ono, Y.; Iikura, H.; Esaki, T.; Koga, T.; Hattori, K.; Watanabe, Y.; Sakamoto, A.; Yoshihashi, K.; Kitazawa, T.; Esaki, K.; Ohta, M.; Sato, H.; Kozono, T.
Design and synthesis of peptidomimetic factor VIIa inhibitors
Chem. Pharm. Bull.
58
38-44
2010
Homo sapiens (P08709)
Plesner, B.; Westh, P.; Nielsen, A.D.
Biophysical characterisation of GlycoPEGylated recombinant human factor VIIa
Int. J. Pharm.
406
62-68
2011
Homo sapiens
Larsen, K.S.; Ostergaard, H.; Olsen, O.H.; Bjelke, J.R.; Ruf, W.; Petersen, L.C.
Engineering of substrate selectivity for tissue factor-factor VIIa complex signaling through protease-activated receptor 2
J. Biol. Chem.
285
19959-19966
2010
Homo sapiens
Soeda, T.; Nogami, K.; Matsumoto, T.; Ogiwara, K.; Shima, M.
Mechanisms of factor VIIa-catalyzed activation of factor VIII
J. Thromb. Haemost.
8
2494-2503
2010
Homo sapiens
Hoffman, M.; Volovyk, Z.; Persson, E.; Gabriel, D.A.; Ezban, M.; Monroe, D.M.
Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity
J. Thromb. Haemost.
9
759-766
2011
Homo sapiens
Zhou, H.; Shi, W.; Zhou, B.; Guo, D.; Wang, T.
Tissue factor-factor VIIa regulates interleukin-8, tissue factor and caspase-7 expression in SW620 cells through protease-activated receptor-2 activation
Mol. Med. Rep.
3
269-274
2011
Homo sapiens
Seested, T.; Nielsen, H.; Christensen, E.; Appa, R.
Cellular and intracellular distribution of recombinant activated factor VII in the rat liver
Thromb. Haemost.
103
860-862
2010
Homo sapiens
Persson, E.; Olsen, O.
Current status on tissue factor activation of factor VIIa
Thromb. Res.
125
S11-S12
2010
Homo sapiens
Seested, T.; Appa, R.S.; Christensen, E.I.; Ioannou, Y.A.; Krogh, T.N.; Karpf, D.M.; Nielsen, H.M.
In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver
Thromb. Res.
127
356-362
2011
Homo sapiens
Maroney, S.A.; Ellery, P.E.; Wood, J.P.; Ferrel, J.P.; Bonesho, C.E.; Mast, A.E.
Caveolae optimize tissue factor-Factor VIIa inhibitory activity of cell-surface-associated tissue factor pathway inhibitor
Biochem. J.
443
259-266
2012
Homo sapiens
Andersen, L.M.; Andreasen, P.A.; Svendsen, I.; Keemink, J.; ?stergaard, H.; Persson, E.
Antibody-induced enhancement of factor VIIa activity through distinct allosteric pathways
J. Biol. Chem.
287
8994-9001
2012
Homo sapiens
Eriksson, O.; Ramstroem, M.; Hoernaeus, K.; Bergquist, J.; Mokhtari, D.; Siegbahn, A.
The Eph tyrosine kinase receptors EphB2 and EphA2 are novel proteolytic substrates of tissue factor/coagulation factor VIIa
J. Biol. Chem.
289
32379-32391
2014
Homo sapiens
Vadivel, K.; Agah, S.; Messer, A.S.; Cascio, D.; Bajaj, M.S.; Krishnaswamy, S.; Esmon, C.T.; Padmanabhan, K.; Bajaj, S.P.
Structural and functional studies of gamma-carboxyglutamic acid domains of factor VIIa and activated protein C: role of magnesium at physiological calcium
J. Mol. Biol.
425
1961-1981
2013
Homo sapiens (P08709)
Vatsyayan, R.; Kothari, H.; Mackman, N.; Pendurthi, U.R.; Rao, L.V.
Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor
PLoS ONE
9
e103505
2014
Homo sapiens
Aberg, M.; Eriksson, O.; Mokhtari, D.; Siegbahn, A.
Tissue factor/factor VIIa induces cell survival and gene transcription by transactivation of the insulin-like growth factor 1 receptor
Thromb. Haemost.
111
748-760
2014
Homo sapiens
Sheffield, W.P.; Bhakta, V.
The M358R variant of alpha1-proteinase inhibitor inhibits coagulation factor VIIa
Biochem. Biophys. Res. Commun.
470
710-713
2016
Homo sapiens
Gajsiewicz, J.M.; Nuzzio, K.M.; Rienstra, C.M.; Morrissey, J.H.
Tissue factor residues that modulate magnesium-dependent rate enhancements of the tissue factor/factor VIIa complex
Biochemistry
54
4665-4671
2015
Homo sapiens
Sorensen, A.B.; Madsen, J.J.; Frimurer, T.M.; Overgaard, M.T.; Gandhi, P.S.; Persson, E.; Olsen, O.H.
Allostery in coagulation factor VIIa revealed by ensemble refinement of crystallographic structures
Biophys. J.
116
1823-1835
2019
Homo sapiens (P08709)
Eriksson, O.; Thulin, A.; Asplund, A.; Hegde, G.; Navani, S.; Siegbahn, A.
Cross-talk between the tissue factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer
BMC Cancer
16
341
2016
Homo sapiens
Sorensen, A.B.; Madsen, J.J.; Svensson, L.A.; Pedersen, A.A.; Ostergaard, H.; Overgaard, M.T.; Olsen, O.H.; Gandhi, P.S.
Molecular basis of enhanced activity in factor VIIa-trypsin variants conveys insights into tissue factor-mediated allosteric regulation of factor VIIa activity
J. Biol. Chem.
291
4671-4683
2016
Homo sapiens (P08709)
Prasad, R.; Sen, P.
Structural modulation of factor VIIa by full-length tissue factor (TF1-263) implication of novel interactions between EGF2 domain and TF
J. Biomol. Struct. Dyn.
36
621-633
2018
Homo sapiens (P08709)
Priestley, E.S.; Cheney, D.L.; DeLucca, I.; Wei, A.; Luettgen, J.M.; Rendina, A.R.; Wong, P.C.; Wexler, R.R.
Structure-based design of macrocyclic coagulation factor VIIa inhibitors
J. Med. Chem.
58
6225-6236
2015
Homo sapiens
Zhang, X.; Glunz, P.W.; Johnson, J.A.; Jiang, W.; Jacutin-Porte, S.; Ladziata, V.; Zou, Y.; Phillips, M.S.; Wurtz, N.R.; Parkhurst, B.; Rendina, A.R.; Harper, T.M.; Cheney, D.L.; Luettgen, J.M.; Wong, P.C.; Seiffert, D.; Wexler, R.R.; Priestley, E.S.
Discovery of a highly potent, selective, and orally bioavailable macrocyclic inhibitor of blood coagulation factor VIIa-tissue factor complex
J. Med. Chem.
59
7125-7137
2016
Homo sapiens
Rothmeier, A.S.; Versteeg, H.H.; Ruf, W.
Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells
J. Thromb. Haemost.
17
627-634
2019
Homo sapiens
Prasad, R.; Sen, P.
Molecular determinants involved in differential behaviour between soluble tissue factor and full-length tissue factor towards factor VIIa
Phys. Chem. Chem. Phys.
19
22230-22242
2017
Homo sapiens
Gajsiewicz, J.M.; Morrissey, J.H.
Structure-function relationship of the interaction between tissue factor and factor VIIa
Semin. Thromb. Hemost.
41
682-690
2015
Homo sapiens
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